Primary extragonadal germ cell tumor: A case report on prostate seminoma

Zheng, Wei; Wang, Lina; Yang, Deyong; Fang, Kun; Chen, Xiaochi; Wang, Xuejian; Li, Xiancheng; Li, Ziyao; Song, Xishuang; Wang, Jianbo

doi:10.3892/ol.2015.3592

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…[ 2 ] Primary extragonadal germ cell tumors of the prostate are very rare, with fewer than 20 cases described in the literature. [ 6 , 7 ] Hashimoto et al reported a primary seminoma of the prostate in a 54 years old male, whose main complaint was difficulty with urination. They first suspected sarcoma of the prostate and were diagnosed with seminomas by needle biopsies of the prostate.…”

Section: Discussionmentioning

confidence: 99%

“…Because patients with KS have substantially decreased androgen levels, the risk of prostate cancer is significantly decreased [2] . Primary extragonadal germ cell tumors of the prostate are very rare, with fewer than 20 cases described in the literature [6,7] . Hashimoto et al reported a primary seminoma of the prostate in a 54 years old male, whose main complaint was difficulty with urination.…”

Section: Discussionmentioning

confidence: 99%

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Primary seminoma of prostate in a patient with Klinefelter syndrome

Shi¹,

Chen²,

Huang

et al. 2022

Medicine

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Rationale: Klinefelter syndrome (KS) is a sex differentiation syndrome that occurs in men and is characterized by the 47XXY genotype. An association between KS and cancer has also been reported. The occurrence of seminoma of the prostate in KS has not been reported in the literature to date. Primary seminoma should be included in the differential diagnosis of prostate neoplasms in patients with KS. Patient concerns: A 39-year-old man presenting with urinary retention was admitted to our hospital. Physical examination revealed sparse pubic hairs, atrophic testes, and an underdeveloped penis. Hormonal examination revealed significantly lowered serum testosterone levels and markedly higher follicle-stimulating hormone levels. A chromosomal examination was performed. Computed tomography and magnetic resonance imaging imaging showed a neoplasm in the left lobe of the prostate, and immunohistochemical examination of a transrectal needle biopsy of the prostate was performed. Diagnoses: Chromosomal examination was exhibited a 47 XXY genotype. Histopathology and of Immunohistochemistry of the transrectal needle biopsy specimen confirmed a seminoma. No other neoplasm was found on systemic examination; therefore, the patient was diagnosed with primary prostate seminoma and Klinefelter syndrome. Interventions: The patient refused any treatment except catheterization because of religious reason. Outcomes: The patient died 2 years later. Lessons: Primary seminoma should be included in the differential diagnosis of neoplasms of the prostate in patients with KS. Transrectal ultrasound-guided prostate needle biopsy is essential for the diagnosis of prostate neoplasms, and cisplatin-based chemotherapy remains the primary treatment for seminoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary seminoma of prostate in a patient with Klinefelter syndrome

Shi¹,

Chen²,

Huang

et al. 2022

Medicine

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“…Similar to our case, five of the six cases with outcome data noted invasion of adjacent structures (seminal vesicles and bladder base) [ 2 , 6 - 9 ]. Of the six, two were treated with chemotherapy only [ 6 , 9 ], one was treated with chemotherapy followed by radiotherapy [ 7 ], and three were treated with a combination of surgery and chemotherapy [ 2 , 8 , 10 ]. Of the three patients who received surgery, one was treated with radical prostatectomy, another with pelvic exenteration, and the last with TURP.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy as a Single Modality in Primary Seminoma of the Prostate

Akingbade

Gopaul²,

Brastianos

et al. 2021

Cureus

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Extragonadal germ cell tumors (EGCTs) are uncommon, and those involving the prostate are rare. We report on a primary seminoma of the prostate in a 56-year-old male presenting with scrotal pain, urinary frequency and urgency, and erectile dysfunction. Digital rectal examination revealed a hard, markedly enlarged prostate projecting posteriorly into the rectum. All 12 cores from ultrasound-guided prostate biopsy revealed malignant cells that stained positive for OCT4, PLAP, and CD117. Imaging revealed a 10.2 cm x 7.8 cm x 8.4 cm prostate mass with irregular nodular margins extending superiorly to the base of the bladder and posteriorly abutting the anterior rectal wall. There was no evidence of distant metastatic disease on both nuclear medicine and CT scans of the chest, abdomen, and pelvis. An 11 mm right internal iliac lymph node and several tiny sub-centimeter external iliac nodes were noted bilaterally. The patient was treated with radiotherapy to the prostate and pelvic lymph nodes. The pelvic lymph nodes were treated with 20 Gy in eight fractions, followed by a boost to the prostate for a further 20 Gy in eight fractions. There was a significant response during treatment that allowed an adaptive boost for a further 10 Gy in four fractions to bring the total dose to the prostate to 50 Gy in 20 fractions. Treatment was well tolerated. Adjuvant chemotherapy was not recommended. He remains disease-free 24 months post-treatment. This case report indicates that like most seminomas, extragonadal seminomas are exquisitely sensitive to radiotherapy and may be considered for the primary treatment of non-metastatic disease. To our knowledge, this is the first reported case of the sole use of radiotherapy to treat a primary seminoma of the prostate.

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“…It represents 1% to 3% of all GCTs and can be classified as seminomatous, which comprises 60% of all primary EGGCT formed only by the classical seminoma, and non-seminomatous including embryonal carcinoma (EC), teratoma (mature or immature), yolk sac carcinoma (YST) and choriocarcinoma. EGGCT constituted by two or more histotypes is referred to as mixed germ cell tumor [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Mediastinal Seminoma Associated With Testicular Microlithiasis and Liver Injury

Ramos¹,

Tarekegn²,

Ciobanu³

et al. 2021

Cureus

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Mediastinal seminomas are rare neoplasms that can be found incidentally in asymptomatic patients. However, a few cases may present in the emergency room with mild to severe respiratory and/or cardiovascular symptoms. This can occur when the tumor grows large enough to cause compression and obstruction of the various structures present in the thorax. Here we present a case of a large medium mediastinal seminoma that grew to the extent of causing pulmonary artery compression which led to chronic passive backflow through the hepatic veins and hepatic congestion. This case was remarkable as well for the presence of testicular microlithiasis, a rare feature with unknown significance to date.

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Primary extragonadal germ cell tumor: A case report on prostate seminoma

Cited by 8 publications

References 18 publications

Primary seminoma of prostate in a patient with Klinefelter syndrome

Primary seminoma of prostate in a patient with Klinefelter syndrome

Radiotherapy as a Single Modality in Primary Seminoma of the Prostate

A Case of Primary Mediastinal Seminoma Associated With Testicular Microlithiasis and Liver Injury

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