Primary experimental infection of riverine buffaloes with Fasciola gigantica

Yadav, Shobha; Sharma, Rinku; Kalicharan, A; Mehra, U. R.; Dass, Ram; Verma, Ashok Kumar

doi:10.1016/s0304-4017(99)00005-9

Cited by 32 publications

(35 citation statements)

References 11 publications

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“…Like other metazoan diseases, the Okao (1984) and Fabiyi (1987) Ethiopia 30-90 Fabiyi (1987) severity and the course of the disease in buffaloes vary with the dose of MC ingested, in a primary single massive dose or perpetual and recurrent lower doses, over a shorter or a prolonged period. A primary infection dose of 800-1000 F. gigantica MC caused acute disease with pathognomic clinical manifestations synchronous with growth and maturation of the infection dose and was incidental to 20-33.3% mortality in Murrah buffalo yearlings (Yadav et al 1999b;Edith et al 2010c). The prepatent period of F. gigantica in riverine buffaloes is longer (92-97 days) than F. hepatica (50-70 days) in large ruminants.…”

Section: Pathogenesismentioning

confidence: 99%

“…Grossly the carcasses were emaciated and had icteric appearance, extensive gelatinization of subcutaneous fat, hepatomegaly (1.5 times) and liver had rounded margins. The establishment of adult flukes in biliary network was associated with enlarged, thickened and mineralized and prominent bile ducts beneath the liver capsule and distended gall bladder (Yadav et al 1999b;Edith et al 2010a). A hepatic load of 368 ± 110 adult flukes could cause death in buffalo calves, aged above 6 months by Day 140 post-infection (pi).…”

Section: Pathogenesismentioning

confidence: 99%

“…A hepatic load of 368 ± 110 adult flukes could cause death in buffalo calves, aged above 6 months by Day 140 post-infection (pi). Coprological egg counts[300/g was suggestive of acute fasciolosis, while its subsequent fall to 100-200/g was symbolic to onset of chronic phase of the disease and/or immune carrier status of the host (Yadav et al 1999b).…”

Section: Pathogenesismentioning

confidence: 99%

“…Various factors, such as haematophagia, haemorrhages during migratory phase and injurious nature of the fluke metabolites discharged into the host circulation significantly contribute to the development of anaemia (Ganga et al 2004a). Buffalo calves, suffering from the acute course of the disease, with mean fluke load of 300 and above had a significant fall in erythrocytic indices during late prepatency caused normocytic normochromic anaemia (Yadav et al 1999b;Ganga et al 2007), whereas in the chronic phase, hypoalbumineamia is more marked than anaemia and an immune carrier host, on partial recovery from the acute course of the disease, continues to suffer from normocytic hypochromic anaemia (Edith et al 2010b). …”

Section: Anaemiamentioning

confidence: 99%

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Epizootiology, pathogenesis and immunoprophylactic trends to control tropical bubaline fasciolosis: an overview

Sharma¹,

Godara²,

Thilagar³

2011

J Parasit Dis

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On the Indian sub-continent, nearly 5,000 years ago, the domestication of the riverine buffalo-the incredible Asian dairy animal was initiated. It plays a versatile role in socio-economic upliftment of its owners from the rural agricultural communities in Asian, African, South American and a few European countries. Comparatively, buffaloes are lesser evolved and susceptible to infectious diseases than cattle. However, poor body thermoregulation and wallowing nature predisposed them to snail borne infections, especially tropical fasciolosis-an incessant major constraint on buffalo production and improvement programmes. This review article is an insight into the global prevalence, varied epizootiological factors, offers possible explanation to pathophysiological clinical signs, deleterious effects of the tropical liver fluke, involving hepato-biliary system, haemopoitic system, endocrine glands and their secretions, oxidative stress, altered metabolism and significant fall in food conversion efficiency with unaffected digestibility of nutrients. Besides, the authors have briefly discussed and reviewed the developments and significance of successful immunodiagnostic approaches for detecting and forecasting the disease during early pre-patency and feasibility of developing a cost effective immunoprotection strategies against tropical fasciolosis.

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Section: Pathogenesismentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: Anaemiamentioning

confidence: 99%

See 2 more Smart Citations

Epizootiology, pathogenesis and immunoprophylactic trends to control tropical bubaline fasciolosis: an overview

Sharma¹,

Godara²,

Thilagar³

2011

J Parasit Dis

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“…Fasciola gigantica inflicts heavy economic loss on the livestock industry in the tropical world in general and an adverse impact on health, weight gain, feed conversion efficiency and reproduction of buffaloes (Bubalus bubalis) in particular (FAO 1994;Yadav et al 1999;Mehra et al 1999). India, being an agrarian society, has the largest buffalo population in the world, which constitutes a very significant component of the Indian livestock sector (Banerjee 1991;Agricultural Research Data Book 2002).…”

Section: Introductionmentioning

confidence: 99%

Vaccination of buffaloes with Fasciola gigantica recombinant fatty acid binding protein

et al. 2005

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Recombinant fatty acid binding protein (rFABP) of Fasciola gigantica was expressed in Escherichia coli and used as vaccine in Freund's adjuvant to evaluate the level of protection induced in buffalo (Bubalus bubalis) calves. Fifteen buffalo calves were distributed to three groups of five calves each. An antigen dose of 400 mug for each of the three immunizations at 3-week intervals, and a challenge dose of 600 metacercariae was administered per calf. Levels of anti-FABP antibodies increased rapidly by 2 weeks after the first immunization and were always significantly higher in the immunized-challenged group than in the infected control group. Immunization with FABP induced both humoral and cell-mediated immune response in these animals. Vaccination showed a moderate level of protection in terms of reduced fluke burden (35.8%) and liver damage as assayed by aspartate aminotransferase and sulfhydryl group levels as well as anti-fecundity effect of the vaccine.

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Comparison of modulation of sheep, mouse and buffalo lymphocyte responses by Fasciola hepatica and Fasciola gigantica excretory-secretory products

et al. 2005

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In order to explain the difference in susceptibility to Fasciola hepatica and F. gigantica between animal species, the activity of their excretory-secretory products (FhESP and FgESP, respectively) on concanavalin A (ConA)-induced proliferation of different animal species (sheep, mouse and buffalo) lymphocytes was compared. At high doses, FhESP inhibited proliferation of lymphocytes of all the animal species tested, and at low doses they inhibited the proliferation of sheep lymphocytes and increased the proliferation of buffalo and mouse lymphocytes. The effects of FgESP were similar but the intensity of FgESP inhibition was less than FhESP. The immunomodulatory effects of FhESP or FgESP could not alone explain the susceptibility level of hosts to Fasciola spp. The immunomodulatory molecules of FhESP and FgESP and their role in the course of Fasciola spp. infection should be further investigated.

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Primary experimental infection of riverine buffaloes with Fasciola gigantica

Cited by 32 publications

References 11 publications

Epizootiology, pathogenesis and immunoprophylactic trends to control tropical bubaline fasciolosis: an overview

Epizootiology, pathogenesis and immunoprophylactic trends to control tropical bubaline fasciolosis: an overview

Vaccination of buffaloes with Fasciola gigantica recombinant fatty acid binding protein

Comparison of modulation of sheep, mouse and buffalo lymphocyte responses by Fasciola hepatica and Fasciola gigantica excretory-secretory products

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