Primary exchanger dysfunction: A possible explanation for insulin resistance syndrome

Gout: On the brink of novel therapeutic options for an ancient disease

“…IR has been proposed to promote hyperuricemia, partly by enhancing renal urate reabsorption via overactivity of renal Na + /H + exchange (50). But, Na + /H + antiporter overactivity may be primarily a product of hypertension rather than IR, and the resorptive capacity of the antiporter for urate has not been defined (51).…”