Primary Ewing sarcoma of the lung: A systematic review of the recent literature

A Report of a Rare Case of BCOR (B-cell Line 6 Corepressor)-Altered Sarcoma of the Lung in a Child

“…Even more rare is primary pulmonary ES as described by Fedeli et al who identified 50 cases of primary pulmonary ES in the last decade. BAS are rare with a much lower incidence than ES [ 10 ]. In our literature review, of the total 169 cases of BAS identified, no cases were identified with the primary tumor site of the lung.…”

“…Identifying molecular aberrations can help identify potential targets for future novel therapies [ 5 ]. However, molecular testing is not standard practice for these tumors as Fedeli et al found that fluorescence in situ hybridization (FISH) and molecular testing were scantly performed in the 50 cases of primary pulmonary ES cases they identified [ 10 ]. Histologically, BAS are identified as primitive round and spindle cells in sheets, nests, and fascicles [ 15 ].…”

Primary Pulmonary Ewing's Sarcoma: A Surprise Diagnosis in a 52-Year-Old Active Smoker

“…1 E). 3 The cells were negative for cytokeratin, TTF1, and CD 45. This profile suggested round cells of undifferentiated sarcoma from the Ewing family.…”

“…Furthermore, the mean age at diagnosis of primary PES reported in the literature was 30.5 years, with only a few cases being diagnosed after the age of 50. 3 …”

“…Generally, primary PES is an aggressive and lethal disease, especially when locally advanced and unresectable. 3 Tumor metastasis at diagnosis, large tumor size, and invasion of the heart are indicative of poor prognosis. 5 …”