Primary Ewing sarcoma of the kidney

Doroudinia, Abtin; Ahmadi, Sara; Mehrian, Payam; Pourabdollah, Mihan

doi:10.1136/bcr-2018-227198

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…Primary ESFT of the kidney is rarely reported. 33 - 41 However, in the present series, involvement of kidney was seen in 7 (median age of presentation: 30 years) patients. Further ESFTs in bladder and prostate noted in this cohort were rarely reported.…”

Section: Discussioncontrasting

confidence: 62%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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Introduction: The diagnosis of Ewing sarcoma family of tumours (ESFT) is challenging, especially in adults and in extra-skeletal or visceral location. Several morphologic mimics with varied treatment options and prognosis confer diagnostic dilemmas. Application of ancillary diagnostic modalities in surgical pathology in clinical routine has enabled accurate diagnosis of ESFT in bone, soft tissues, and viscera. Aim: The study aims to assess the clinicopathological features including molecular test results of ESFT with emphasis on sex, age, and location, especially extra-skeletal soft tissue and visceral location. Material and Methods: Data of clinicopathological, molecular tests (wherever performed), diagnosis rendered in 302 ESFT over a decade from our centre were reviewed. Statistical comparison of skeletal and extra-skeletal tumours with reference to age and sex was done using SPSS package. The P value of <.05 was considered significant. Results: The cohort included 302 ESFTs with 49% skeletal and 51% extra-skeletal tumours. Thigh was most common site among skeletal tumours; chest wall, paraspinal location, and retroperitoneum among soft tissues (39.4%); and kidney, ovary, and cervix among visceral tumours (11.3%). Fluorescence in situ hybridisation for EWSR1 gene rearrangement was positive in 54 patients and reverse-transcriptase polymerase chain reaction in 19 patients. Predominance of male sex, younger age and location in extremities among skeletal tumours and lack of gender predilection, higher age and axial location in extra-skeletal tumours were noted, which were statistically significant. Molecular tests were performed more frequently in extra-skeletal tumours, especially in visceral tumours to establish the diagnosis. Conclusions: The study showed statistically significant differences in the age, sex, and location between skeletal and extra-skeletal ESFT. The increased percentage of extra-skeletal tumours especially in viscera was attributed to the increased awareness and availability of ancillary techniques.

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Section: Discussioncontrasting

confidence: 62%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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“… 3 Usually, the diagnosis of ES/PNET is done with abnormal abdominal TACS. 1 , 2 , 4 , 5 25–50% of pathological reports have metastasis when diagnosticated. 3 Overall recommendations are immunohistochemistry and histopathological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“… 3 Overall recommendations are immunohistochemistry and histopathological diagnosis. 1 , 2 , 3 , 4 , 5…”

Section: Discussionmentioning

confidence: 99%

“…2 PET/CT with 18 FDG allows the evaluation of metastases and the response to treatment. 4 Complementary imaging studies are necessary for the complete diagnosis of this entity, especially in an extraosseous presentation.…”

Section: Discussionmentioning

confidence: 99%

“…The localization in the genitourinary system such as kidney, bladder, and prostate are extremely rare. 4 There are less than 100 cases reported in the literature of ES/PNET with renal condition. 5 We present a case of an ES/PNET with renal presentation and treatment after its diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Ewing's sarcoma / Primitive Neuro-Ectodermic Tumor in the kidney. A case report

Bustos

Meneses

Hernández

et al. 2022

Urology Case Reports

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Ewing's sarcoma/Primitive Neuro-Ectodermic Tumor of the kidney accounts for less than 1% of all kidney tumors. We present the case of a 37-year-old male with abdominal pain secondary to a right renal tumor of 7 × 7 × 5 cm. A robotic right radical nephrectomy was performed. In the histopathological and immunohistochemistry was reported NKX2.2(+), CD99(+), synaptophysin(+), and FLI-1(+). Extraosseous Ewing's Sarcoma was diagnosed. The patient was treated with: Doxorubicin, Vincristine, Mesna, and Isophosphamide.

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Ewing sarcoma/primitive neuroectodermal tumor of the ureter: A case report and literature review

周倩

杜国波

唐洁

et al. 2021

Oncology and Translational Medicine

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Ewing sarcoma/primary neuroectodermal tumors are rare, invasive, and small round blue cell tumors. There are few reports of its occurrence in the urinary system. Here, we present the first middle-aged female patient whose Ewing sarcoma primary site was in the ureter. The main clinical manifestation was intermittent hematuria. She was in good health after complete surgical resection and adjuvant radiotherapy. To date, there has been no recurrence or metastasis. Accurate early diagnosis and appropriate treatment can help prolong survival. 18F-fluorodeoxyglucose positron emission tomography/computed tomography is expected to be an effective means of evaluating treatment effects and detecting metastasis and recurrence. In this article, besides introducing a case of Ewing sarcoma/primitive neuroectodermal tumor of the ureter, we review the literature to discuss the current status of diagnosis and treatment.

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Primary Ewing sarcoma of the kidney

Cited by 9 publications

References 9 publications

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Ewing's sarcoma / Primitive Neuro-Ectodermic Tumor in the kidney. A case report

Ewing sarcoma/primitive neuroectodermal tumor of the ureter: A case report and literature review

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