Primary epithelioid sarcoma of the kidney and adrenal gland: report of 2 cases with immunohistochemical and molecular cytogenetic studies

Alikhan, Mir; Pease, Garrison; Watkin, William; Grogan, Raymon H.; Krausz, Thomas; Antic, Tatjana

doi:10.1016/j.humpath.2016.09.024

Cited by 15 publications

(35 citation statements)

References 16 publications

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“…Most ES cases present as soft tissue mass(es) and are diagnosed on resection specimens . Solid organ ES is extremely rare, with most of the cases reported in the uterine corpus, uterine cervix, kidney, and adrenal gland .…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, this is the first case report of ES diagnosed by CT‐guided core biopsy, and the second ES case described arising as a primary in the adrenal gland. The first primary adrenal gland ES was reported by Alikhan M et al in 2017 on a resection case …”

Section: Introductionmentioning

confidence: 99%

“…The first primary adrenal gland ES was reported by Alikhan M et al in 2017 on a resection case. 4 the core biopsy were cellular, with epithelioid tumor cells occurring singly and in clusters with moderate amount of granular eosinophilic cytoplasm, irregular nuclear borders, nuclear hyperchromasia with prominent nucleoli, mitoses, and focal necrosis ( Figure 2A). Adrenal cortical carcinoma was initially in our differential diagnosis due to the tumor location and initial cytomorphology evaluation.…”

Section: Introductionmentioning

confidence: 99%

“…The mitotic activity usually is low (less than five5 per high-power field), and necrosis is often present. Less commonly, ES can exhibit bland spindle cell morphology.Most ES cases present as soft tissue mass(es) and are diagnosed on resection specimens 4,14,15. Solid organ ES is extremely rare, with most of the cases reported in the uterine corpus, uterine cervix, kidney, and adrenal gland 4,14,16.…”

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confidence: 99%

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Primary adrenal gland epithelioid sarcoma: A case report and literature review

Huang

Nayar

Zhou

2019

Diagnostic Cytopathology

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Epithelioid sarcoma is a malignant mesenchymal neoplasm with morphologic and immunophenotypic epithelioid differentiation, which rarely arises in solid organs. We report a case of primary epithelioid sarcoma in the adrenal gland of a 31‐year‐old female. The patient initially presented with nausea and rectal bleeding, and subsequent imaging studies revealed a 4.4 cm left adrenal gland mass and left retroperitoneal lymphadenopathy. Clinical and radiological studies did not reveal tumor elsewhere in the patient. Histologic features were those of epithelioid sarcoma, proximal type with cohesive clusters of epithelioid tumor cells harboring frequent mitoses, and areas of necrosis. Immunohistochemical stains showed strong, diffuse expression of epithelial markers (pancytokeratin), and CD34 and Fli‐1. Partial and focal positive staining of CK7 was also noted. Nuclear expression of SMARCB1 (INI‐1) protein was lost. ERG was negative in this case. We believe that this is the second‐case report of a primary adrenal gland epithelioid sarcoma. Fli‐1 positivity was seen in our case, and ERG was negative as shown in some recent publications regarding epithelioid sarcomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Primary adrenal gland epithelioid sarcoma: A case report and literature review

Huang

Nayar

Zhou

2019

Diagnostic Cytopathology

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“…The patient is a 72‐year‐old man with a history of type 2 diabetes (managed with metformin and Lispro Insulin) and hypertension (managed with lisinopril and nifedipine) who was being followed for recurrent epithelioid sarcoma of the right adrenal gland . In late 2017, he was found to have a new left adrenal gland mass, concerning for metastatic disease.…”

Section: Case Presentationmentioning

confidence: 99%

An abdominal wall mass of exogenous insulin amyloidosis in setting of metastatic sarcoma

Carll

Antic

2019

J Cutan Pathol

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Exogenous insulin amyloidosis (AIns) is an iatrogenic form of amyloidosis which is found in diabetic patients, generally localized to the site of subcutaneous insulin administration. It may form a discrete mass that could come to clinical attention, and can contribute to abnormal pharmacokinetics of the exogenous insulin, resulting in worsened control of diabetes. In this case report, we describe such a lesion in a 72‐year‐old man with a history of type 2 diabetes and primary adrenal gland epithelioid sarcoma and discuss the diagnostic challenges it poses.

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Immunohistochemical Biomarkers of Mesenchymal Neoplasms in Endocrine Organs: Diagnostic Pitfalls and Recent Discoveries

Hung

Hornick

2018

Endocr Pathol

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Mesenchymal neoplasms rarely present in or adjacent to endocrine organs. In this context, the recognition of these rare tumor types can be challenging, with significant potential for misdiagnosis as sarcomatoid carcinomas (i.e., anaplastic thyroid carcinoma and sarcomatoid adrenal cortical carcinoma) or neuroendocrine carcinomas, depending upon the dominant histologic patterns. In this review, we address potential pitfalls in diagnosing selected mesenchymal neoplasms arising within or near endocrine organs, including dedifferentiated liposarcoma, synovial sarcoma, angiosarcoma, PEComa, proximal-type epithelioid sarcoma, Ewing sarcoma, and neuroblastoma. For each of these tumor types, we review clinical and pathologic features, histologic clues to distinguish them from endocrine neoplasms, and recently developed immunohistochemical markers that can be particularly useful for establishing the correct diagnosis.

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Primary epithelioid sarcoma of the kidney and adrenal gland: report of 2 cases with immunohistochemical and molecular cytogenetic studies

Cited by 15 publications

References 16 publications

Primary adrenal gland epithelioid sarcoma: A case report and literature review

Primary adrenal gland epithelioid sarcoma: A case report and literature review

An abdominal wall mass of exogenous insulin amyloidosis in setting of metastatic sarcoma

Immunohistochemical Biomarkers of Mesenchymal Neoplasms in Endocrine Organs: Diagnostic Pitfalls and Recent Discoveries

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