Primary Epithelial Myoepithelial Carcinoma of Lung, Reporting of a Rare Entity, Its Molecular Histogenesis and Review of the Literature

Arif, Farzana; Wu, Susan; Andaz, Shahriyour; Fox, Stewart

doi:10.1155/2012/319434

Cited by 20 publications

(16 citation statements)

References 15 publications

(14 reference statements)

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“…These tumors primarily occur in the adult population with a peak incidence in the fifth and sixth decades of life. 1,2,4,[8][9][10][11][12][13][14][15][16] Mucoepidermoid carcinoma (MEC) is the most common SGT of the pulmonary system. 17 It is one of the few primary lung tumors that can also affect the pediatric population in whom it comprises as much as 9% of all lung malignancies.…”

Section: Clinical and Radiologic Featuresmentioning

confidence: 99%

“…Among this group, epithelial-myoepithelial carcinoma (EMC) predominates with approximately 25 cases reported in the medical literature. 2,[9][10][11][12][13][14] The sex distribution of pulmonary SGT varies with tumor subtype. Male predominance has been recorded for ACC, whereas MEC and EMC appear to show more of an equal sex distribution.…”

Section: Clinical and Radiologic Featuresmentioning

confidence: 99%

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Primary Pulmonary Salivary Gland-type Tumors

Falk

Weissferdt

Kalhor

et al. 2016

Advances in Anatomic Pathology

104

100

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Pulmonary salivary gland-type tumors (SGT) comprise a very small proportion of primary lung neoplasms. The most common tumors among this group are mucoepidermoid carcinoma and adenoid cystic carcinoma. Contrary to the head and neck region, benign SGT such as pleomorphic adenomas are exceedingly rare in the pulmonary system. More recently, 2 additional SGT, namely hyalinizing clear cell carcinoma and salivary duct-like carcinoma were recognized as primary lung tumors expanding the spectrum of SGT that have been described to originate in the tracheobronchial system. Primary pulmonary SGT must be clinically excluded from metastatic salivary gland neoplasms as their morphology is indistinguishable from that of their salivary gland counterparts. Little is known about the clinical behavior and best treatment approach for these unusual tumors. In this review, we provide a comprehensive summary of primary pulmonary SGT with particular emphasis on morphologic characteristics and latest developments in terms of immunohistochemical and molecular techniques.

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Section: Clinical and Radiologic Featuresmentioning

confidence: 99%

Section: Clinical and Radiologic Featuresmentioning

confidence: 99%

Primary Pulmonary Salivary Gland-type Tumors

Falk

Weissferdt

Kalhor

et al. 2016

Advances in Anatomic Pathology

104

100

View full text Add to dashboard Cite

show abstract

“…As a marker, Ki-67 is frequently used in salivary gland tumors to distinguish HGT lesions from pre-existing components (12). The previously reported Ki-67 labeling index for salivary gland EMCs ranged from <1-12% (14). The Ki-67 labeling index in the higher-grade component in the present case was 14.2%, a value that exceeds the acceptable range for a low-grade lesion, as the salivary EMC is low grade (5).…”

Section: Discussionmentioning

confidence: 99%

Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes

Tajima¹,

Aki²,

Yajima³

et al. 2015

Oncology Letters

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Abstract. Primary salivary gland-type tumors of the lung are rare; among them, epithelial-myoepithelial carcinomas (EMC) represent a minor histological subtype. The present case documents an EMC that occluded the B8 segment of the left lung in a 72-year-old woman. Macroscopically, the tumor was well-demarcated; however, microscopic examination demonstrated that it had infiltrated the lung parenchyma. The majority of the tumor mass was composed of a myoepithelial overgrowth in conjunction with conventional bilayered ductal structures comprising epithelial and myoepithelial cells. At the advancing edge of the tumor, the myoepithelial overgrowth was observed to be gradually transitioning to a higher-grade component, which demonstrated venous invasion. The Ki-67 labeling index was reduced compared with high-grade transformation (HGT) of salivary gland EMC; p53 was sparsely observed on immunostaining. However, cyclin D1, which is reported to be overexpressed in certain subtypes of salivary gland carcinomas with HGT, was overexpressed in the higher-grade component of the tumor, indicating a potential HGT initiation. The surgical margin was tumor free, and no recurrence has been observed for 4 months. A thorough follow-up is required considering the HGT-like changes and venous invasion of the tumor. Additional studies are required to elucidate the characteristics of pulmonary EMC, with an emphasis on detecting HGT or HGT-like changes.

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“…Epithelial-myoepithelial carcinomas are rare tumors. They are typically salivary gland in origin with only about 30 reported cases in the tracheobronchial tree [3–12] . The World Health Organization defines EMCs as a “malignant tumor composed of variable proportions of 2-cell types … represented by an inner layer of duct lining, epithelial-type cells, and an outer layer of clear myoepithelial-type cells” [13] .…”

Section: Discussionmentioning

confidence: 99%

Tracheal epithelial-myoepithelial carcinoma associated with sarcoid-like reaction: A case report

Dong

Tatsuno

Betancourt

et al. 2015

Respiratory Medicine Case Reports

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Epithelial-myoepithelial carcinomas are rare tumors that primarily originate in the salivary glands but have also been found in the tracheobronchial tree. We report the first case of epithelial-myoepithelial carcinoma associated with sarcoidosis. A 61 year old Hispanic man presented with altered mental status and hypercalcemia. Imaging revealed diffuse intra-thoracic and intra-abdominal lymphadenopathy. A diagnostic bronchoscopy was performed where an incidental tracheal nodule was discovered and biopsied. Pathology was consistent with epithelial-myoepithelial carcinoma. Lymph node biopsy demonstrated non-caseating granulomas consistent with sarcoidosis. Patient underwent tracheal resection of the primary tumor with primary tracheal reconstruction. Hypercalcemia subsequently normalized with clinical improvement. Repeat CT imaging demonstrated complete resolution of lymphadenopathy. Our findings are suggestive of a possible paraneoplastic sarcoid-like reaction to the epithelial-myoepithelial carcinoma with associated lymphadenopathy and symptomatic hypercalcemia.

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Primary Epithelial Myoepithelial Carcinoma of Lung, Reporting of a Rare Entity, Its Molecular Histogenesis and Review of the Literature

Cited by 20 publications

References 15 publications

Primary Pulmonary Salivary Gland-type Tumors

Primary Pulmonary Salivary Gland-type Tumors

Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes

Tracheal epithelial-myoepithelial carcinoma associated with sarcoid-like reaction: A case report

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