Primary Epithelial Malignancies of the Lacrimal Gland: The 2003 Ramon L. Font Lecture

Shields, Jerry A.; Shields, Carol L.; Epstein, John A.; Scartozzi, Richard; Eagle, Ralph C.

doi:10.1097/01.iop.0000103003.87842.bb

Cited by 101 publications

(84 citation statements)

References 79 publications

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“…gland tumors have already been examined in previous studies [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Since these investigations were performed mainly in Western countries with a predominantly Caucasian population, it was the purpose of our study to examine the histological characteristics and associated clinical features of epithelial lacrimal gland tumors in the population of mainland China.…”

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confidence: 95%

Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients

Zeng

Shi

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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confidence: 95%

Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients

Zeng

Shi

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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“…The rarity of these lesions necessitates adoption of the continually evolving and diversifying classification scheme for the salivary gland tumors. This successful application of salivary gland classification to the lacrimal gland neoplasms is reflected in a decline in frequency of primary lacrimal gland adenocarcinoma from 10% of all malignant lacrimal gland tumors in a 2003 review by Shields et al [6] to 5% in a classification reappraisal by Weis and colleagues in 2009 [7]. Since that time, the advances in the understanding of molecular pathogenesis of the salivary gland neoplasia have led to emergence of new diagnostic entities, which are reflected in the most recent 4th edition of the World Health Organization Classification of Head and Neck Tumours [8].…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma, Not Otherwise Specified, Arising in Accessory Lacrimal Gland: A Diagnostic Challenge

Milman

Iacob²,

Lauer

et al. 2017

Ocul Oncol Pathol

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Neoplasms arising in accessory lacrimal glands are rare. We describe a 33-year-old man with adenocarcinoma arising in the left lower eyelid accessory lacrimal gland. Microscopic evaluation demonstrated an infiltrative neoplasm composed of mildly to moderately pleomorphic cells with abundant eosinophilic cytoplasm and focal intracytoplasmic vacuoles, arranged predominantly in ductules. Foci of luminal and intracytoplasmic eosinophilic secretory material and occasional mucin were noted. An in situ component was identified in the gland of Wolfring. Though perineural invasion was present, high-grade nuclear features, brisk mitotic activity, and comedonecrosis were not identified. Immunohistochemical studies were notable for immunoreactivity of the tumor cells for CK7, carcinoembryonic antigen, BRST-2, androgen receptors, and HER2/neu (2+). The neoplastic cells were negative for CK20, estrogen and progesterone receptors, S-100, p63, calponin, thyroid transcription factor-1, and prostate-specific antigen. Fluorescence in situ hybridization studies for ETV6 and MAML2 rearrangements and for HER2/neu amplification were negative. Because of the absence of unifying morphologic, immunophenotypic, and molecular genetic findings, the diagnosis of adenocarcinoma, not otherwise specified, was rendered. The patient underwent comprehensive oncologic workup, which was negative for another primary tumor and metastases. He remains disease free with a follow-up of 4 years. This case illustrates the challenges encountered in applying salivary gland tumor classification to the accessory lacrimal gland neoplasm.

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“…It is usually seen infiltrating structures in superolateral quadrant with frequent involvement of superior and lateral rectus muscles. The orbital malignant lymphoma usually manifests as a diffuse solid, enhancing mass with molding around the globe on images studies, and reflecting the irregular infiltrative of orbital structures [1,4,[49][50][51][52]. Our result revealed that, on CT and MRI shows, ill-defined margin, irregular shaped, iso-density, iso-intense on T1WI and hyper-intense on T2WI and homogeneous enhancement (7), the earlier studies that showed orbital lymphoma appeared to iso-intense on T1WI and hyper-intense on T2WI [51].…”

Section: Orbital Lymphomamentioning

confidence: 99%

Valuation of Four-Quadrant Location Method in Diagnosis and Differential Diagnosis of the Orbital Tumor by Comparison Study Combining CT and MRI with Pathology

Akter¹,

Hasan²,

Sana³

et al. 2017

J Pain Relief

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Purpose: To valuate four-quadrant location method in diagnosis and differential diagnosis of the orbital tumor by comparison study combining CT and MRI with pathology. Materials and methods:Data of 87 patients (44 female and 43 males), aged 1 to 84 years were recruited in this study, including the computed tomography(CT), Magnetic resonance imaging (MRI), and histopathology diagnosis. All orbital tumors were verified radiologically and pathologically in the Hospital of Jinggangshan University from Sep-2008 to April-2016 patients underwent CT scanning (31 Conventional CT and 18 dynamic contrast enhancements CT) and 38 patients underwent MR Imaging (35 dynamic contrast enhancement MRI and 3 conventional MRI). The clinical data were retrieved from the medical record. We classified the orbital region according to four-quadrant and eight-space (FQES) division and traditional muscleconal division with center point of optic nerve. Results:Among the 87 cases of the orbital tumors, 70 cases (80.45%) were orbital benign tumors and 17 cases (19.54%) were malignant tumors. Regarding the location of the orbit, 41 lesions (47.12%) were in superolateral, 18 lesions (20.68%) were in inferolateral, 16 lesions (18.39%) were in inferomedial, 8 lesions (9.19%) were in superomedial, 3 lesions (3.44%) were in globe, 1 lesion (1.14%) was in optic nerve. The most common tumors are hemangiomas (total 36 cases: 12 in inferolateral, 8 in inferomedial, 9 in superolateral, 7 in superomedial) and 9 cases of pleomorphic adenoma were in superolateral, 9 cases of dermoid cyst ( 7 in superolateral and in 2 inferomedial), 5 cases of inflammatory pseudotumor (4 in superolateral and 1 in inferomedial), 7 cases of lymphoma (3 in superolateral, 2 in inferolateral and 2 in inferomedial ), 3 cases of adenoid cystic carcinoma in superolateral, 3 caese solitary fibrous tumor ( 2 in suprolateral and 1 in inferomedial), 3 cases lipoma (1 in superomedial, 1 in superolateral and 1 in inferolateral), 2 cases choroidal melanoma were in globe, 1 case of metastasis in superolateral, 1 case of meningioma in optic nerve, 1 case of malignant melanoma was in superolateral. The orbital tumors appeared in orbit with mostly regular, oval and rounds shape, well defined margin. The size ranged from 0.8 mm × 4.5 cm to 4.5 cm × 2.0 cm. The CT revealed iso-density in 22, slightly high-density in 15, mixed density in 6, low density in 5 and high density in 1 lesion. Among them, 18 were contrast enhancements. On T1WI image, the MRI revealed low signal intensity in 23 cases, slightly low signal in 4 cases, iso signal intensity in 7 case, high signal intensity in 3 cases, mixed signal intensity in 1 case on T2WI, it revealed high signal intensity in 23 cases, slightly high intensity in 7 cases, low signal intensity in 4 cases, iso signal intensity in 3 cases, mixed signal intensity in 1 case. Among them, 35 contrast enhancement MRI and 3 were non contrast MRI. Benign tumor was diagnosed in 70 patients, of them 34 were male and 36 were female, and the mean age was 45.19 ...

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Primary Epithelial Malignancies of the Lacrimal Gland: The 2003 Ramon L. Font Lecture

Cited by 101 publications

References 79 publications

Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients

Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients

Adenocarcinoma, Not Otherwise Specified, Arising in Accessory Lacrimal Gland: A Diagnostic Challenge

Valuation of Four-Quadrant Location Method in Diagnosis and Differential Diagnosis of the Orbital Tumor by Comparison Study Combining CT and MRI with Pathology

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