Primary endometrial squamous cell carcinoma with extensive squamous metaplasia and dysplasia

Bagga, Permeet Kaur; Jaswal, T. S.; Datta, U; Mahajan, Nanak Chand

doi:10.4103/0377-4929.41686

Cited by 17 publications

(14 citation statements)

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“…2 The condition has been strongly associated with pyometra, cervical stenosis, multiparity and chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…18 Management for this condition usually consists of a surgical hysterectomy with adnexectomy and radiotherapy. 2 …”

Section: Discussionmentioning

confidence: 99%

“…The majority of squamous cell carcinoma (SCC) cases represent an extension from the cervix, where SCC spreads superficially to the inner surface of the uterus and replaces the endometrium with carcinoma cells. 2 However, whether primary or secondary, endometrial SCC is rare and PESCC in situ even rarer.…”

Section: ‫اخلاليا‬ ‫و�رسطان‬ ‫احلدوث‬ ‫نادر‬ ‫الرحم،‬ ‫عنق‬ ‫ل�رسطانmentioning

confidence: 99%

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Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

Jetley¹,

Jairajpuri²,

Hassan³

et al. 2015

SQUMJ

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Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical cancer, is a rare entity. Primary endometrial squamous cell carcinoma in situ is even more uncommon; it usually occurs in postmenopausal women and has a strong association with pyometra. We report a 60-year-old multiparous postmenopausal woman who presented to the Hakeem Abdul Hameed Centenary Hospital, New Delhi, India, in May 2014 with a lower abdominal swelling corresponding in size to a pregnancy of 26 gestational weeks and vaginal discharge of one year's duration. A total abdominal hysterectomy with a bilateral salpingooophorectomy was performed, which revealed an enlarged uterus with pyometra. Histopathology showed that the entire endometrial lining had been replaced with malignant squamous cells without invasion of the myometrium. Immunohistochemistry revealed that the tumour cells were positive for p63 with a high Ki-67 labelling index. No adjuvant therapy was required and the patient was disease-free at a seven-month follow-up.

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“…2 The condition has been strongly associated with pyometra, cervical stenosis, multiparity and chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…18 Management for this condition usually consists of a surgical hysterectomy with adnexectomy and radiotherapy. 2 …”

Section: Discussionmentioning

confidence: 99%

Section: ‫اخلاليا‬ ‫و�رسطان‬ ‫احلدوث‬ ‫نادر‬ ‫الرحم،‬ ‫عنق‬ ‫ل�رسطانmentioning

confidence: 99%

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Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

Jetley¹,

Jairajpuri²,

Hassan³

et al. 2015

SQUMJ

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“…[1][2][3][4][5][6] By definition, primary SCC of the endometrium cannot have co-existing primary endometrial adenocarcinoma, connection with cervical squamous epithelium, or co-existing primary cervical SCC. [1][2][3][4][5][6] Primary endometrial SCC may arise in association with squamous metaplasia and dysplasia in the setting of pyometria 7,8 or ichthyosis uteri. [9][10][11] Rare cases of verrucous carcinoma of the endometrium have been also reported.…”

Section: Discussionmentioning

confidence: 99%

Squamous intraepithelial lesions and squamous cell carcinomas detected by endometrial sampling: Pap test correlation and outcome data

Odronic

Brainard

Abdul‐Karim

2015

Journal of the American Society of Cytopathology

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“…2 The presence of squamous epithelium in the endometrium, variously termed as ''ichthyosis uteri,'' ''leukoplakia epidermalization,'' ''psoriatic uteri,'' ''epidermoid heteroplasia,'' ''cholesteometra,'' and ''indirect regenerative squamous metaplasia,'' has been described under a variety of conditions, and is benign in the majority of cases. Primary squamous cell carcinoma may arise through the process of squamous metaplasia, as proposed by Baggish and Woodruff.…”

Section: Discussionmentioning

confidence: 99%

Superficial Endometrial Spread of Squamous Cell Carcinoma of the Cervix (Cake Icing): Two Case Reports and Review of the Literature

Marwah¹,

Garg²,

Singh³

et al. 2012

Journal of Gynecologic Surgery

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Background: Although squamous cell carcinoma of the cervix is the most common gynecologic malignancy in India, superficial spreading carcinoma of the endometrium is rare. The uterine corpus can be involved by direct extension from cervical growth, but superficial spread without invasion of the underlying myometrium is uncommon. Case: Two cases of squamous cell carcinoma of the cervix with superficial extension to the endometrium are reported. Clinically, both cases presented with pyometra. The tumor had spread superficially into the entire endometrial cavity up to the fundus, totally replacing the columnar epithelium. Results: Both patients were diagnosed as having stage 1b cervical squamous cell carcinoma and were treated with hysterectomy and bilateral salpingo-oophrectomy. One patient was lost to follow-up and the other has remained disease free for 48 months. Conclusions: As squamous cell carcinoma of the cervix with superficial extension to the endometrium is a rare phenomenon, with fewer than 40 cases reported in literature so far, this article has been written to emphasize the need for keeping this possibility in mind in cases of carcinoma of the cervix. ( J GYNCOL SURG 28:375)

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Primary endometrial squamous cell carcinoma with extensive squamous metaplasia and dysplasia

Cited by 17 publications

References 0 publications

Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

Squamous intraepithelial lesions and squamous cell carcinomas detected by endometrial sampling: Pap test correlation and outcome data

Superficial Endometrial Spread of Squamous Cell Carcinoma of the Cervix (Cake Icing): Two Case Reports and Review of the Literature

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