Primary endometrial squamous cell carcinoma

Thomakos, N.; Galaal, Khadra; Godfrey, K.; Hemming, D.; Naik, Raj; Hatem, M.H.; Lopes, Alberto

doi:10.1007/s00404-008-0567-x

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…It accounts for 0.1% to 0.5% of all uterine cancers. 49,50 Many of the presumed squamous cell carcinomas thought to be of uterine origin are most likely from the cervix. The criteria for establishing the diagnosis of PESCC are coexisting primary adenocarcinoma of the endometrium, no connection between PESCC and cervical squamous epithelium, no coexisting primary squamous cell carcinoma of the cervix, and clear evidence of squamous differentiation such as intercellular bridges and/or keratin.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

“…The criteria for establishing the diagnosis of PESCC are coexisting primary adenocarcinoma of the endometrium, no connection between PESCC and cervical squamous epithelium, no coexisting primary squamous cell carcinoma of the cervix, and clear evidence of squamous differentiation such as intercellular bridges and/or keratin. 49 Goodman et al 50 reviewed 64 cases of PESCC. Patients tended to be white, non-obese, and older than 67 years of age.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

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Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes

2009

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Section: Squamous Cell Carcinomamentioning

confidence: 99%

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes

2009

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“…We did not have a reasonable explanation for this. Almost all types of endometrial cancer are adenocarcinomatous, [3] and most of the endometrial squamous carcinomas originate from the SCC of the cervix [4] or endometrial stem cell, and squamous metaplasia of the normal endometrium. [5] Primary endometrial SCC is a rare entity.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age

Zhang¹,

Zhang²,

Yang³

et al. 2018

Medicine

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Rationale:Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE.Patient concerns:A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia.Diagnoses:The patient was diagnosed with stage IIIc primary and moderately differentiated endometrial squamous cell carcinoma.Interventions:The patient underwent diagnostic curettage twice and cold knife conization (CKC). Following this total abdominal hysterectomy combined with bilateral adnexectomy and pelvic lymph node, dissection was performed. After the surgery, the patient was treated with radiotherapy and chemotherapy. Tumor markers were followed up regularly after the operation to monitor tumor recurrence and therapeutic effect.Outcomes:Ninety-two days after the operation, there was tumor recurrence of the left pelvic cavity and the patient died after 11 months of follow-up.Lessons:Intrauterine pathology after the 1st diagnostic curettage suggests that high-grade squamous intraepithelial lesion should make the clinician vigilant and investigate the origin of the lesion. Magnetic resonance imaging scans and tumor markers can be used to confirm the diagnosis as soon as possible and avoid unnecessary interventions like CKC.

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“…Diagnosis of PESCC is based on Fluhmann criteria (1928). Briefly, it is mandatory to exclude: cervical carcinoma involving the endometrium, coexistent endometrial adenocarcinoma, and contiguity between the endometrial cancer and the squamous cervix epithelium [3]. The etiopathogenesis of PSCCE is still unknown because of its rarity [4].…”

Section: Discussionmentioning

confidence: 99%

Sacrococcygeal chondroid chordoma: a case report and literature review

Alami¹,

Farhan²,

Houmada³

et al. 2018

Pan Afr Med J

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In this paper, we report a case of primary squamous cell carcinoma of the endometrium (PSCCE) with a literature review. A 64-year-old woman was admitted because of postmenopausal bleeding. The gynecological exam found bleeding from the endocervix. The pelvic ultrasound objectified uterine regular contours, endometrial thickened was 10 mm, the presence of an intra cavitary lesion measuring 56/70 mm. The diagnostic hysteroscopy revealed a whitish appearance taking all the uterine cavity making evoke a tumor of the endometrium. Pelvic MRI showed a tumor limited to the uterine corpus endometrium (invasion by more than 50% of the myometrium) without invasion of the cervix. Radical hysterectomy, bilateral salpingo-oophorectomy, and lymph nodes dissection were performed. Grossly, the endometrial carcinoma was polypoid tumor occupying the entire uterine cavity. Histologically, the diagnosis of SCC was retained. No adenocarcinoma element was recognized. Neither squamous metaplasia nor dysplasia was recognized. No ectopic cervical tissue was found. The SCC was found to invade into deeper one half of the myometrium. No tumor cells were seen in other sites including the cervix, ovaries, parameters, and lymph nodes. The patients was FIGO 2009 stage IB (pT1B, N0), and was treated with adjuvant radiation. The patient had a disease progression in the pelvis 3 months after the irradiation. We reported a case of PSCCE which can help to enrich the literature for the treatment and prognosis of this disease.

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Primary endometrial squamous cell carcinoma

Cited by 12 publications

References 13 publications

Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes

Non-Endometrioid Adenocarcinoma of the Uterine Corpus: A Review of Selected Histological Subtypes

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age

Sacrococcygeal chondroid chordoma: a case report and literature review

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