Primary Endobronchial Leiomyosarcoma

Lee, Sin Hyung; Shim, Jae Jeong; Shin, Jae Seung; Baek, Man Jong; Choi, Young Ho; Kim, Min Kyung; Kim, Cheol Hwan; Lee, Sang Youb; Jo, Jae Youn; In, Kwang Ho; You, Se Hwa; Kang, Kyung Ho

doi:10.1159/000050472

Cited by 9 publications

(4 citation statements)

References 10 publications

(8 reference statements)

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“…Due to the location of the endobronchial lesion, patients may present with symptom of pulmonary obstruction such as chest pain, cough, fever, wheezing, hemoptysis, dyspnea, and even expectoration of tumor fragments. [5] The radiological appearances include the findings of bronchial obstruction such as atelectasis, mediastinal shift and hyperlucency, or pneumothorax. [5]…”

Section: Discussionmentioning

confidence: 99%

“…[5] The radiological appearances include the findings of bronchial obstruction such as atelectasis, mediastinal shift and hyperlucency, or pneumothorax. [5]…”

Section: Discussionmentioning

confidence: 99%

“…The low-grade tumors generally follow a less aggressive course than those of intermediate or high–grade. [5] Other prognostic factors as the size and long-time stability of solitary lung nodules are not necessarily reliable criteria for assessing prognosis. [8]…”

Section: Discussionmentioning

confidence: 99%

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Primary Endobronchial Leiomyosarcoma of the Lung: Clinical, Gross and Microscopic Findings of Two Cases

Elouazzani

Zouaidia

Jahid

et al. 2012

Journal of Clinical Imaging Science

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Primary leiomyosarcoma of the lung is an unusual malignant tumor. Among this entity, the endobronchial form is very rare and the preoperative diagnosis is extremely difficult. We present two different presentations and outcomes of primary endobronchial leiomyosarcoma of the lung. In both cases, the histological study and the immunohistochemical stain, of the surgical resection, provided the final diagnosis. Through those cases we present the diagnostic and therapeutic difficulties encountered.

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Section: Discussionmentioning

confidence: 99%

“…[5] The radiological appearances include the findings of bronchial obstruction such as atelectasis, mediastinal shift and hyperlucency, or pneumothorax. [5]…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Endobronchial Leiomyosarcoma of the Lung: Clinical, Gross and Microscopic Findings of Two Cases

Elouazzani

Zouaidia

Jahid

et al. 2012

Journal of Clinical Imaging Science

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“…However, sleeve lobectomy, pneumonectomy, or carinal resection may be necessary to complete resection and prolong survival, depending on the anatomic location and size of the tumor [ 8 ]. Survival following excision of these tumors is better than that for a primary lung carcinoma [ 15 ]. Chemotherapy has been suggested in cases with metastases; however, it lacks efficacy, resulting in only partial response [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Smooth Muscle Tumors: A Series of Five Cases Highlighting Pitfalls in Diagnosis

Nakra¹,

Kakkar²,

Agarwal³

et al. 2018

J Pathol Transl Med

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BackgroundPrimary endobronchial smooth muscle tumors (SMTs), which are extremely rare, include endobronchial leiomyomas and leiomyosarcomas. Clinically, SMTs present with signs and symptoms of bronchial obstruction, and lack specific radiological findings. Thus, histopathological examination is required for accurate diagnosis as well as for tumor grading. We examined the histomorphological and immunohistochemical features of endobronchial SMTs and highlighted pitfalls in diagnosis, particularly when using small biopsies. MethodsCases of primary endobronchial SMTs diagnosed at our Institute over the last 6 years (2012–2017) were retrieved from the departmental archives. Histopathological features and immunohistochemistry performed for establishing the diagnosis were reviewed. ResultsFive cases of SMTs occurring in endobronchial locations were identified. These included three cases of leiomyoma, and two cases of leiomyosarcoma. The age distribution of patients ranged from 13 to 65 years. Leiomyomas showed more consistent staining with smooth muscle markers (smooth muscle actin, desmin, and smooth muscle myosin heavy chain), while tumors of higher grade showed variable, focal staining, leading to erroneous diagnosis, especially on small biopsies. ConclusionsThe diagnosis of endobronchial SMTs relies on histopathological examination, for both confirmation of smooth muscle lineage and determination of the malignant potential of the lesion. Appropriate immunohistochemical panels including more than one marker of smooth muscle differentiation are extremely valuable for differential diagnosis from morphological mimics, which is necessary for instituting appropriate management.

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Incidentally detected leiomyosarcoma of lingular lobe of left lung—a case report

Biswas

Woodward

Banerjee

et al. 2011

Indian J Thorac Cardiovasc Surg

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Primary Endobronchial Leiomyosarcoma

Cited by 9 publications

References 10 publications

Primary Endobronchial Leiomyosarcoma of the Lung: Clinical, Gross and Microscopic Findings of Two Cases

Primary Endobronchial Leiomyosarcoma of the Lung: Clinical, Gross and Microscopic Findings of Two Cases

Endobronchial Smooth Muscle Tumors: A Series of Five Cases Highlighting Pitfalls in Diagnosis

Incidentally detected leiomyosarcoma of lingular lobe of left lung—a case report

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