Primary dural non-hodgkin′s lymphoma mimicking meningioma

Abstract

A 42-year-old immunocompetent female presented with headache, vomiting and diminished unilateral vision. Computed tomography and magnetic resonance imaging were suggestive of high-grade meningioma. Neurological examination and routine hematological parameters were within normal limits. Craniotomy was performed; the tumor was arising from the dura mater, which was completely resected. Hematoxylin and eosin showed lesion comprising a tumor mass with monomorphic population of tumor cells arranged in sheets and small follicles. The tumor cells were immunoreactive for leukocyte common antigen and CD20 and immunonegative for glial fibrillary acid protein, epithelial membrane antigen, cytokeratin, CD3 and CD30. Rest of the body scan was normal. A diagnosis of primary dural non-Hodgkin's lymphoma was made. We report this exceedingly rare case of primary dural non-Hodgkin's lymphoma, which mimicked clinically and radiologically as meningioma.

Extra-axial primary non-Hodgkin's CNS lymphoma mimicking meningioma, in a 5-year-old immunocompetent child: a rare entity

“…Direct involvement of the CNS occurs in 1–2% of patients with lymphoma. Common clinical manifestations of primary CNS lymphoma are in the form of raised intracranial pressure (headaches and vomiting), decrease in vision, fever, altered mental status, seizures and cranial nerve involvement or focal neurological deficit 3 4. Our patient presented with headache, vomiting and cranial nerve involvement.…”

“…Non-Hodgkin lymphomas represent only about 4% of all lymphomas in the general population and occur more frequently in patients with AIDS 3. Direct involvement of the CNS occurs in 1–2% of patients with lymphoma.…”

“…Non-Hodgkin's lymphoma in an immunocompetent paediatric patient has been rarely reported 2 3. We report a case of extra-axial non-Hodgkin's central nervous system (CNS) lymphoma in an immunocompetent paediatric patient.…”

Marginal zone dural lymphoma: the Memorial Sloan Kettering Cancer Center and University of Miami experiences

“…Patients were identified through institutional databases at both sites and were included in this report if they met the following criteria: 1) clinical presentation of a dural mass and no evidence of primary parenchymal brain involvement, 2) brain imaging demonstrating an extra-axial mass arising from the dura mater, 3) pathologic confirmation of lymphoma, 4) primary neurological presentation. Our review identified twenty six patients with DL, five of whom were reported previously (1).…”

“…The exact incidence of DL is unknown, and the published data consist of small reports and case series (1–3). DL occurs more frequently in middle aged women, in contrast to parenchymal PCNSL which is more common in men (1, 2).…”