Primary diffuse large B-cell non-Hodgkin lymphoma of the cranial vault

Abstract

A B S T R A C TPrimary non-Hodgkin lymphoma of the cranial vault with extra and intracranial extension in a nonimmunocompromised patient is extremely uncommon. Until date, only limited number of such cases has been reported in the literature and none was the lesion located as a diffuse swelling in the forehead. Imaging of the present case showed in a homogenous contrast enhancement mass involving the scalp of bifrontal supraorbital compartment and intracranial extra axial extension through the frontal bone with extension to the right orbit and right ethmoidal sinus. The intracranial mass was excised along with involved dura. Histopathology of the mass showed diffuse large B-cell non-Hodgkin lymphoma.

Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

“…Our patient was diagnosed at the age of 26, much younger than the median age of this population which was 48 years in 19 similar cases of primary bone lymphoma of the skull which we reviewed [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

“…The clinical presentation was the most commonly seen with skull lymphoma, where most cases reviewed also presented with a scalp lump or swelling [6][7][8][9][10][11][12][13], [15,21,22].…”

“…Other presentations included headache [9,10,13,14,18,20] focal neurological deficits such as loss of vision [10] , behavioral changes [10] , double vision [14] , facial nerve palsy 14, and seizures [19,22] . Four of the cases were also confused with a meningioma [13,[17][18][19][20] and one case with osteomyelitis [16].…”

“…Most of the cases reviewed were treated with a low intensity chemotherapy regimen similar to CHOP or CEOP with or without Rituximab [7][8][9][10][11][12][13][14][15][16][17][18][19][20] and one case was treated with high dose methotrexate [17].…”