Primary diffuse large B-cell lymphoma of the sigmoid colon

Erginöz, Ergin; Aşkar, Ahmet; Çavuş, Gökçe Hande; Velidedeoğlu, Mehmet

doi:10.1016/j.ijscr.2021.106454

Cited by 6 publications

(13 citation statements)

References 24 publications

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“…Management of relapse and refractory diseases depends on whether the patient is a candidate for a hematopoietic stem cell transplant. High-dose chemotherapy with autologous stem cell rescue is shown to improve survival in these patients [1]. The overall prognosis of colonic lymphomas is poor, and these patients need to be monitored at regular intervals with frequencies based on response to initial chemotherapy and staging of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Diffuse Large B-Cell Lymphoma of the Colon in an Asymptomatic Patient

Bandaru¹,

Busa²,

Juneja³

2022

Cureus

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Extranodal lymphomas of the gastrointestinal (GI) tract are known entities, but primary lymphoma of the colon is extremely rare. Symptoms are non-specific, such as abdominal pain, bloody diarrhea, unintentional weight loss, night sweats, and changes in bowel habits. Some patients do not have any specific symptoms, which makes diagnosis extremely difficult. We present a 69-year-old asymptomatic male who was incidentally found to have an inflammatory mass in the descending colon on screening colonoscopy; the initial biopsy was inconclusive. However, due to high suspicion of any underlying malignancy, a repeat colonoscopy with biopsy was done, which revealed diffuse large B-cell lymphoma (DLBCL). Prompt and early diagnosis is extremely crucial for timely management. Management includes chemotherapy, radiotherapy, and surgery.

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Section: Discussionmentioning

confidence: 99%

“…Primary diffuse large B-cell lymphoma of the colon is extremely rare. It affects both men and women, with male predominance and the peak incidence seen in the sixth to seventh decades [1,2]. There are only a few cases of DLBCL of the colon reported so far.…”

Section: Introductionmentioning

confidence: 99%

Diffuse Large B-Cell Lymphoma of the Colon in an Asymptomatic Patient

Bandaru¹,

Busa²,

Juneja³

2022

Cureus

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“…Other subtypes include Burkitt's lymphoma, mantle cell lymphoma, and follicular lymphoma. When the colon is involved, studies show that there is a male predominance with the onset in the 6th to 7th decade of life [8][9][10]. More so, predisposing factors have not been identified; however, some literature states that celiac disease [8], immunosuppression, HIV, and inflammatory bowel disease have increased incidence in the development of this neoplasm [2,10].…”

Section: Discussionmentioning

confidence: 99%

“…NHL is a form of malignant neoplasm that originates from T lymphocytes, B lymphocytes, and natural killer cells [ 8 ]. Of the many subtypes of B cell lymphomas, DLBCL is the most common.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus-Positive Primary Diffuse Large B-cell Lymphoma of the Colon in a Patient With Human Immunodeficiency Virus

Bethel¹,

Veeraballi²,

Chittamuri³

et al. 2022

Cureus

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Colorectal lymphomas of primary origin are rare neoplasms accounting for 3% of all lymphomas involving the gastrointestinal (GI) tract, and of that 3%, 0.1-0.5% involve the colorectal region. Among the types of non-Hodgkin's lymphomas involving the GI tract, diffuse large B-cell lymphoma (DLBCL) is the most common type. While extranodal involvement of DLBCL in the GI is common, DLBCL of the colon with Epstein-Barr virus positivity is a rare entity with only a few cases reported in the literature. Here, we present a rare case of a 53-year-old female with human immunodeficiency virus (HIV) who presented with generalized abdominal pain, weight loss, night sweats, and fevers. A computed tomography scan of the abdomen and pelvis showed a mass on the right side of the colon with associated retroperitoneal and right inguinal lymphadenopathy. She later underwent a colonoscopy with a biopsy. Histopathology showed DLBCL of the ascending colon and chemotherapy was initiated.

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“…The clinical presentation is not different from the classical adenocarcinoma (“B symptoms” are frequently absent) being very heterogeneous and depending on the involved site. The treatment is based on surgery and chemotherapy, however, in many cases, when the first biopsy allows a correct diagnosis and obstruction and/or bleeding are not present, poly-chemotherapy and anti-CD20 immunotherapy can induce complete and long-lasting responses making the surgery unnecessary [ 5 ]. Stage at presentation is the most important prognostic factors for survival.…”

Section: Rare Tumors Of Colon and Rectummentioning

confidence: 99%

Clinical and Molecular Characteristics of Rare Malignant Tumors of Colon and Rectum

Ottaiano

Santorsola

Perri

et al. 2022

Biology

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The most frequent form of colorectal cancer is represented by adenocarcinoma being about 98% of tumor histological types. However, other rare histotypes can be found in colon and rectum (adenosquamous, goblet cell adenocarcinoma, lymphoma, medullary carcinoma, melanoma, mesenchymal, neuroendocrine, plasmacytoma, signet ring, squamous tumors). Altogether, these forms account for less than 2% of colorectal tumors. There are no specific diagnostic or therapeutic recommended approaches and most of the information available from literature derives from small and retrospective clinical series. In the present study, we provide a paramount and updated view on clinical and biologic characteristics of rare colorectal tumors.

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Primary diffuse large B-cell lymphoma of the sigmoid colon

Cited by 6 publications

References 24 publications

Diffuse Large B-Cell Lymphoma of the Colon in an Asymptomatic Patient

Diffuse Large B-Cell Lymphoma of the Colon in an Asymptomatic Patient

Epstein-Barr Virus-Positive Primary Diffuse Large B-cell Lymphoma of the Colon in a Patient With Human Immunodeficiency Virus

Clinical and Molecular Characteristics of Rare Malignant Tumors of Colon and Rectum

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