Primary diffuse large B-cell lymphoma of uterine cervix diagnosed by cytology and concurrent cervical biopsy: a case report and literatures reviews since 1980

Abstract

Malignant lymphoma of the uterine cervix is rare with non-specific clinical presentation and is di ficult to diagnose via cervical cytology. The current study presents a case of primary malignant lymphoma of the uterine cervix diagnosed via initial conventional smear cytology and subsequent cervical biopsy. We present a case of an 81-yearold woman with vaginal bleeding post-urination. The conventional smear cytology showed scattered large atypical lymphoid cells with necrotic debris. The concurrently biopsied specimen revealed large monotonous atypical lymphoid cells, which were immunoreactive for CD20 with high Ki-67 proliferative index, consistent with di fuse large B-cell lymphoma (DLBCL). Due to the transfer of the patient to another hospital, any other examinations associated with staging were not performed. Although rare, the likelihood of malignant lymphoma should be considered while screening for cervical cancer through cytology using Pap smear or conventional smear. Cytological screening may be useful for the early diagnosis of malignant lymphoma of the uterine cervix. Immediate and appropriate treatment can be initiated with a quick and accurate diagnosis. Herein, we report a case of primary uterine cervical DLBCL and review the literatures comprising 106 cases studies with 255 cases of primary cervical lymphoma reported since 1980 including clinical and histological characteristics through MEDLINE database.