Primary diffuse large B-cell lymphoma of the breast

Popović, Lazar; Jovanović, Đorđe; Matovina-Brko, Gorana; Petrović, Danijela; Nikin, Zoran; Roganović, Tatjana

doi:10.2298/aoo0904080p

Cited by 3 publications

(6 citation statements)

References 10 publications

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“…In our study, the median age was 50 years, which is comparable to the 5th decade of life published by other authors [ 7 - 11 , 14 , 15 ].…”

Section: Discussionsupporting

confidence: 86%

“…With the exception of the recently published prospective Mexican trial (Aviles) and the large study of the International Extranodal Lymphoma Study Group (IELSG) with genuine PBLs and sufficient follow-up, which identified 204 patients [ 6 ], in the literature there were only retrospective studies with a relatively limited number of patients that have provided some interesting information [ 7 - 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The usual clinical feature of a breast lymphoma is a rapidly expanding, painless mass [ 11 , 12 ]. There is a slight predilection for the right breast, but the explanation for this remains unclear [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Primary breast lymphomas are most commonly B-cell lymphomas; approximately one-half are diffuse large B-cell lymphoma. Indolent histologies, follicular non-Hodgkin’s lymphoma or extranodal marginal zone (MALT) lymphoma occur less commonly [ 7 - 11 , 14 - 17 ]. All of our cases also had DLBCL.…”

Section: Discussionmentioning

confidence: 99%

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Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review

et al. 2012

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Introduction Primary breast lymphoma is an uncommon disease with poor clinical outcome. Breast lymphomas present less than 0.5% of malignant breast neoplasms and 2.2% of extranodal lymphomas. This study investigated the clinicopathological features and optimal treatment of PBL. Case presentations Clinical records of seven Moroccan PBL patients, treated at the National Institute of Oncology, Rabat, Morocco, from 2002 to 2010, were reviewed. Six of the patients were women and one a man, with ages ranging from 32 to 76. Five patients had stage IE and two stage IIE. All of the patients were classified with DLBCL. Of seven patients, one received a mastectomy and three excision of the breast lesion. Axillary dissection was performed in three patients. Two patients received chemotherapy followed by radiotherapy, while four received chemotherapy alone. Complete remission (CR) following primary treatment for all patients with PBL except in two cases was obtained. In one patient, recurrence occurred. Conclusions There is no consensus on the question of how to best treat PBL: Mastectomy offers no benefit in the treatment of PBL. The combined therapy approach, with chemotherapy and radiotherapy, is the most successful treatment. PBL is poorly represented in rituximab-containing trials in DLBCL patients; there is not much experience with this agent in breast DLBCL. Because of the high incidence of central nervous system (CNS) involvement in PBL patients, many authors strongly believe that patients with aggressive forms of PBL should receive CNS infiltration prophylaxis.

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“…In our study, the median age was 50 years, which is comparable to the 5th decade of life published by other authors [ 7 - 11 , 14 , 15 ].…”

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review

et al. 2012

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“…It is typically a B cell which accounts for up to 50% of all PBL [ 1 ]. A minority of cases are follicular lymphoma, mucosa-associated lymphoid tissue lymphoma, or Burkitt lymphoma [ 5 , 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Primary breast lymphoma: a case series and review of the literature

et al. 2023

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Background Primary breast lymphoma (PBL) is a very rare form of non-Hodgkin's lymphoma (NHL), defined as a malignant primary lymphoma occurring in the breast in the absence of previously detected lymphoma localizations. Our study aims to retrospectively evaluate the epidemiological, clinical, and imaging findings and therapeutic features of breast lymphomas in patients with primary lymphoma of the breast. Materials and methods This is a retrospective study including 13 patients with primary non-Hodgkin's lymphoma of the breast treated at the Salah Azaiez Institute of Oncology from 2000 to 2019. This sample includes 1 case of follicular lymphoma, 2 cases of large T-cell lymphoma, and 10 cases of large B-cell lymphoma. Results Patients included in the study were aged between 17 and 89 years (average age of 52.6 years). All patients were referred because of a lump in the breast, and only one patient consulted with inflammatory signs in the breast. The average clinical size of the tumor was 7.2 cm, with a maximum of 15 cm. Mammography showed an oval mass with circumscribed margins in the majority of cases. Ultrasound showed in most cases a hypoechoic irregular mass or multilobulated mass with irregular margins and hypervascular on color Doppler. Magnetic resonance imaging (MRI) was performed on only three patients and showed a spiculated lesion with polycyclic limits. Eight patients underwent surgery. In our study breast lymphomas involved 10 cases of large B-cell lymphoma, one case of follicular lymphoma, and two cases of large T-cell lymphoma. In this series, 11 patients had localized stages (I + II) at diagnosis, and 2 patients had disseminated stages (stage III) of primary breast lymphoma. Seven patients underwent chemotherapy treatment alone, and five had chemotherapy with radiotherapy. The median follow-up of our patients was 53 months, ranging from 1 to 177 months. Overall survival was 71% at 3 years and 51% at 5 years. Conclusion Primary breast lymphoma is an uncommon type of breast malignancy. The optimal treatment modality is still in question because of the rarity of this disease. However, the use of combination therapy produces the most favorable results. Surgery is not yet recommended.

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Linfoma primario de mama bilateral con metástasis a sistema nervioso central en mujer embarazada. Reporte de caso

González-Zambrana,

Corrales-Pérez,

López-Alvarado

et al. 2024

GAMO

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Primary diffuse large B-cell lymphoma of the breast

Abstract: Primary breast lymphoma is rare location of this disease. Diffuse large B-cell lymphoma is the most common histological subtype. We presented two cases of primary diffuse large B-cell lymphoma of the breast and reviewed a literature about this topic

Cited by 3 publications

References 10 publications

Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review

Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review

Primary breast lymphoma: a case series and review of the literature

Linfoma primario de mama bilateral con metástasis a sistema nervioso central en mujer embarazada. Reporte de caso

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