Primary cutaneous T‐cell lymphoma, unspecified, exhibiting an aggressive clinical course and a cytotoxic phenotype

Yamamoto, Mari; Nakada, Tokio; Iijima, Masafumi

doi:10.1111/j.1365-4632.2008.03587.x

Cited by 6 publications

(12 citation statements)

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“…Based on World Health Organization‐European Organization for Research and Treatment of Cancer diagnostic criteria of cutaneous lymphomas, 2 Yamamoto et al. 1 classified their patient as having primary cutaneous peripheral T‐cell lymphoma (PTL), unspecified. However, the only distinction between this diagnosis and primary cutaneous aggressive CD8 + T‐cell lymphoma was the lack of CD8 reactivity, although the clinical course and epidermotropism fit well to the latter entity 1 .…”

Section: Discussionmentioning

confidence: 99%

“… 1 classified their patient as having primary cutaneous peripheral T‐cell lymphoma (PTL), unspecified. However, the only distinction between this diagnosis and primary cutaneous aggressive CD8 + T‐cell lymphoma was the lack of CD8 reactivity, although the clinical course and epidermotropism fit well to the latter entity 1 . In this study, we also failed to demonstrate the presence of CD8 in tumor cells.…”

Section: Discussionmentioning

confidence: 99%

“…We have read with great interest the recently published case report by Yamamoto et al. 1 describing a patient with primary cutaneous aggressive T‐cell lymphoma that exhibited cytotoxic phenotype, however, without the expression of CD8 antigen. In the light of this publication, we would like to present a similar patient history, which, in our opinion, provides further data in regard of this unique type of cutaneous lymphoma.…”

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confidence: 99%

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Primary cutaneous peripheral T‐cell non‐Hodgkin lymphoma, not otherwise specified, with cytotoxic features

Reich¹,

Maj²,

Schlué³

et al. 2010

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Primary cutaneous peripheral T‐cell non‐Hodgkin lymphoma, not otherwise specified, with cytotoxic features

Reich¹,

Maj²,

Schlué³

et al. 2010

Int J Dermatology

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“…1 A cytotoxic phenotype has been reported. 3,7 Recently, Battistella et al 8 reported a form of cutaneous peripheral T-cell lymphoma expressing a follicular helper T-cell phenotype. Molecular biologic assays reveal a clonal rearrangement of TCR genes.…”

Section: Discussionmentioning

confidence: 99%

A Challenging Cutaneous T-Cell Lymphoma

Khadhar

Chelly²,

Zehani³

et al. 2016

The American Journal of Dermatopathology

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Cutaneous peripheral T-cell lymphomas not otherwise specified (CPTL-NOS) are rare neoplasms accounting for just 2% of cutaneous peripheral T-cell lymphomas (CPTL). Only very few case series have been reported. They represent a phenotypically and prognostically heterogenous group of CPTL that do not fit into any of CPTL well-defined subtypes. The authors report a case of a 64-year-old man with simultaneous plaque-like lesions and disseminated nodules growing rapidly on the face, trunk, and extremities over a 6-month period. There was no a history of preceding patches, erythematous plaques, rash, or pruritic lesions. These lesions were extending over 80% of the skin surface. Histopathologic analysis revealed dense diffuse infiltrates composed of mostly medium-sized to large lymphoid cells throughout the entire dermis without epidermotropism. Neoplastic cells were atypical with markedly pleomorphic nuclei. Immunohistochemistry showed that the tumor cells were positive for CD3, CD4, and CD5 with a loss of CD7. They were negative for CD20, CD8, CD56, CXCL13, PD1, TIA-1, granzyme-B, perforin, CD25, and CD30. The proliferative fraction was low, with MIB-1 labeling less than 10% of cells. The authors diagnosed the patient with primary CPTL-NOS. Despite the rarity of these tumors, clinicians as well as dermatopathologists and pathologists should be familiar with these rare CPTL especially because most of these lymphomas have an aggressive behavior and exhibit an unfavorable prognosis.

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“…Variable T-cell phenotypes (CD4 1 or CD8 1 or CD4/CD8-double-negative and -double-positive) with or without expression of cytotoxic proteins are found. [66][67][68] By definition, most tumor cells do not express CD30. 1 An aberrant expression of CD20, but not additional B-cell markers, can be observed in a subset of cases.…”

Section: Cutaneous Peripheral T-cell Lymphoma Unspecifiedmentioning

confidence: 99%

Pathologic Diagnosis of Cutaneous Lymphomas

Kempf

Mitteldorf

2015

Dermatologic Clinics

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Primary cutaneous lymphomas comprise a prognostically heterogeneous group of lymphocytic skin neoplasms, which display a broad spectrum of clinical, histologic, immunophenotypic, and genetic features. The histopathological examination plays an essential role and is often the starting point in the diagnostic workup of cutaneous lymphomas. In most cases, the histopathological and the phenotypic analysis alone are limited to provide a list of differential diagnoses. As a consequence of overlapping clinical, histologic, phenotypic, and genetic features among several entities of cutaneous lymphomas, the clinicopathological correlation is of utmost importance to achieve the final diagnosis.

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Primary cutaneous T‐cell lymphoma, unspecified, exhibiting an aggressive clinical course and a cytotoxic phenotype

Cited by 6 publications

References 6 publications

Primary cutaneous peripheral T‐cell non‐Hodgkin lymphoma, not otherwise specified, with cytotoxic features

Primary cutaneous peripheral T‐cell non‐Hodgkin lymphoma, not otherwise specified, with cytotoxic features

A Challenging Cutaneous T-Cell Lymphoma

Pathologic Diagnosis of Cutaneous Lymphomas

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