Primary cutaneous small cell carcinoma of the vulva arising from squamous cell carcinoma

Matsumoto, Riki; Bito, Toshinori; Washio, Keiichi; Ikeda, Taro; Oka, Masafumi; Manabe, Toshiaki; Nishigori, Chikako

doi:10.1111/j.1365-2133.2011.10451.x

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…In addition, the detection of polyomavirus helps as a differentiating feature. With the literature being limited, most of the reported cases were found admixed with other histological types, most commonly squamous cell carcinoma and vulvar intraepithelial neoplasia [ 105 ]. FIGO staging of vulvar NEN is described in Table 13 and Figure 16 .…”

Section: Vulvar Necmentioning

confidence: 99%

Neuroendocrine Neoplasms of the Gynecologic Tract

Virarkar

Vulasala

Morani

et al. 2022

Cancers

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Gynecological tract neuroendocrine neoplasms (NEN) are rare, aggressive tumors from endocrine cells derived from the neuroectoderm, neural crest, and endoderm. The primary gynecologic NENs constitute 2% of gynecologic malignancies, and the cervix is the most common site of NEN in the gynecologic tract. The updated WHO classification of gynecologic NEN is based on the Ki-67 index, mitotic index, and tumor characteristics such as necrosis, and brings more uniformity in the terminology of NENs like other disease sites. Imaging plays a crucial role in the staging, triaging, restaging, and surveillance of NENs. The expression of the somatostatin receptors on the surface of neuroendocrine cells forms the basis of increasing evaluation with functional imaging modalities using traditional and new tracers, including 68Ga-DOTA-Somatostatin Analog-PET/CT. Management of NENs involves a multidisciplinary approach. New targeted therapies could improve the paradigm of care for these rare malignancies. This article focuses on the updated staging classifications, clinicopathological characteristics, imaging, and management of gynecologic NENs of the cervix, ovary, endometrium, vagina, and vulva, emphasizing the relatively common cervical neuroendocrine carcinomas among these entities.

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Section: Vulvar Necmentioning

confidence: 99%

Neuroendocrine Neoplasms of the Gynecologic Tract

Virarkar

Vulasala

Morani

et al. 2022

Cancers

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“…To our knowledge, only few case reports of vulvar SCNECs have been reported so far and they were all admixed with other tumor histologies, most commonly vulvar intraepithelial neoplasia and squamous cell carcinoma (Matsumoto et al, 2011). Because of the extremely low incidence of vulvar and vaginal NECs, there is no evidence-based data on the potential role of HPV as an etiopathogenetic factor, which can only be speculated based on the strong association found in squamous cell vulvar/vaginal carcinomas and in cervical NECs.…”

Section: Vulvar Necsmentioning

confidence: 99%

The puzzle of gynecologic neuroendocrine carcinomas: State of the art and future directions

Caruso

Sassu

Tomao

et al. 2021

Critical Reviews in Oncology/Hematology

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Vulvar cancer: a review for dermatologists

Chokoeva¹,

Tchernev

Castelli

et al. 2015

Wien Med Wochenschr

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Vulvar malignancies are important tumors of the female reproductive system. They represent a serious health issue with an incidence between 2 and 7 per 100,000 and year. We provide a review about most important cancer entities, i.e., melanoma, squamous cell carcinoma, basal cell carcinoma, neuroendocrine cancer, and skin adnexal malignancies.Squamous cell carcinoma is the most common vulvar malignancy that can develop from vulvar intraepithelial neoplasia or de novo. Basal cell carcinoma represents only 2% of all vulvar cancers. Melanoma of the vulva exists in two major types-superficial spreading and acral lentiginous. A special feature is the occurrence of multiple vulvar melanomas. Of the adnexal cancer types Paget's disease and carcinoma are seen more frequently than other adnexal malignancies. The dermatologist should be aware of this problem, since he might be the first to be consulted by patients for vulvar disease. Treatment should be interdisciplinary in close association to gynecologists, oncologists, and radiologists.

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Primary cutaneous small cell carcinoma of the vulva arising from squamous cell carcinoma

Cited by 9 publications

References 7 publications

Neuroendocrine Neoplasms of the Gynecologic Tract

Neuroendocrine Neoplasms of the Gynecologic Tract

The puzzle of gynecologic neuroendocrine carcinomas: State of the art and future directions

Vulvar cancer: a review for dermatologists

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