Primary cutaneous sarcomatoid carcinoma presenting as a rapidly‐growing and ulcerative tumor of the skin

Liaw, Tse-Yuan

doi:10.1016/j.kjms.2017.03.006

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…6 , 15 Complete excision of the lesion with 10 mm free circumferential margin is the treatment of choice; adjuvant chemotherapy or radiotherapy has not been shown to be beneficial. 8 The patient had a wide local excision and has had no recurrence more than a year since then.…”

Section: Discussionmentioning

confidence: 95%

“…The most widely accepted theory is the monoclonal hypothesis which postulates the divergence of a single totipotent stem cell into separate epithelial and mesenchymal directions. 8 Another view is that the sarcomatous component of the tumor is a metaplastic transformation of the carcinomatous component. 6 , 9 Some authors have suggested the possibility of a collision between two different tumors or a pseudosarcomatous reaction within the epithelial malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Primary Carcinosarcoma of the Skin in an African Albino: Case Report and Review of Literature

Ndukwe¹,

Chiemeka²,

Menkiti³

et al. 2022

Oman Med J

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Albinism results from a deficiency of the protein responsible for melanin production in melanocytes. Albinos are at an increased risk of dermatoses and malignancies. Primary carcinosarcoma of the skin is an exceedingly rare biphasic tumor composed of malignant epithelial and mesenchymal elements with an unclear histogenesis. To our knowledge, this has not been reported in an African albino. Here, we report the index case of this rare tumor in an albino of African descent.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Primary Carcinosarcoma of the Skin in an African Albino: Case Report and Review of Literature

Ndukwe¹,

Chiemeka²,

Menkiti³

et al. 2022

Oman Med J

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“…Sarcomatoid carcinoma (SC) is a rare, complex, and highly malignant tumor that presents biphasically in terms of epithelial carcinoma and mesenchymal-like sarcoma components. Since its first report in 1864, SC has been documented in various organs including the lungs, uterus, kidneys, bladder, colon, liver, gallbladder, and skin (1)(2)(3)(4)(5)(6)(7)(8). Among all head and neck malignancies, the incidence of sarcomatoid carcinoma was 0.57% (9).…”

Section: Introductionmentioning

confidence: 99%

Sintilimab combined with anlotinib as first-line treatment for advanced sarcomatoid carcinoma of head and neck: a case report and literature review

Wang,

Huang,

Sun

2024

Front. Oncol.

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Sarcomatoid carcinoma (SC) is a rare, complex, aggressive tumor that spreads rapidly, is highly malignant, and has metastasized. Surgical resection is the primary treatment, and it usually occurs in the lungs and kidneys but rarely in the neck. Patients with advanced sarcomatoid carcinoma (SC) of the head and neck (HN) have a poor progonsis. In recent years, immune checkpoint inhibitors (ICIs) have been established as treatments for many solid tumors; however, the effectiveness of ICIs in treating SC of HN is still little recognized. We report a case study of a middle-aged woman with primary sarcomatoid carcinoma of the neck. She developed sarcomatoid carcinoma of the contralateral neck 7 months after the first surgical treatment. Subsequently, disease recurrence and metastasis occurred 8 months after the second surgery. The patient did not receive any treatment after both surgeries. The tumor showed high programmed death-ligand 1 (PD-L1) expression, with a combined positive score (CPS): 95. The patient’s response to treatment was assessed as partial remission (PR) after 2 cycles of anlotinib combined with sintilimab. The patient has survived for over 2 years and remains in PR status, despite experiencing grade 2 hypothyroidism as an adverse event during treatment. The case highlights the efficacy and safety of anlotinib and sintilimab as a first-line treatment.

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Primary cutaneous sarcomatoid carcinoma presenting as a rapidly‐growing and ulcerative tumor of the skin

Cited by 2 publications

References 5 publications

Primary Carcinosarcoma of the Skin in an African Albino: Case Report and Review of Literature

Primary Carcinosarcoma of the Skin in an African Albino: Case Report and Review of Literature

Sintilimab combined with anlotinib as first-line treatment for advanced sarcomatoid carcinoma of head and neck: a case report and literature review

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