Primary cutaneous plasmacytoma: Report of a case with review of the literature

Treatment and Outcomes for Primary Cutaneous Extramedullary Plasmacytoma: A Case Series

“…As in the present analysis, earlier reviews of patients with pcp have reported a mean age of 60, with male predominance 1,2,31 . The lesions are often described as reddish or purple nodules or plaques without ulceration 2,12,31 .…”

“…The lesions are often described as reddish or purple nodules or plaques without ulceration 2,12,31 . The most consistently reported prognostic factor is the number of lesions, with outcomes being better with solitary lesions than with multiple lesions at presentation 1,[12][13][14] . Solitary lesions tended to have less locoregional or distant dissemination and remained confined to the skin 1,31 ; however, large solitary lesions might have a higher risk of Reported as a plasmacytoma, but staining for kappa and lambda chains was negative 29 .…”

“…The present systematic review summarizes all published nonreactive cases of pcp. The most recent comprehensive literature reviews of pcp were published by Muscardin et al 1 (Figure 4), although the data are limited by short follow-up and a small sample size.…”

“…Furthermore, details of treatment are poorly described; many case reports focus only on the pathologic diagnosis 3,[8][9][10][11] . Although extramedullar y plasmacytomas are associated with good clinical outcomes, patients with pcp can develop local recurrence, distant skin recurrence, or systemic progression to multiple myeloma 1,2 . Some authors have suggested an association with improved clinical outcomes in patients with a solitary pcp lesion compared with multiple pcp lesions 1,[12][13][14] .…”

“…Primary cutaneous plasmacytoma (pcp) is a rare diagnosis, with fewer than 50 cases estimated to be have been reported and compiled in the literature [1][2][3] . Cutaneous deposits of plasma cells are more commonly seen in the context of multiple myeloma, where such deposits are associated with poor prognosis 4,5 .…”