“…It is also possible that benign plasmacytoses were included in the analysis because information about monoclonality was not available for all reported cases; that limitation is acknowledged by Muscardin et al 1 in their earlier review. Indeed, 3 of the historical patients in the review 15,16,18 could potentially have had benign tumours with plasma cell infiltrates or plasmacytic granulomas 23,26,31,32,49,68 ; diagnosis requires careful histologic and immunohistochemical analysis 9 . Exclusion of the former 3 patients does not change the survival analysis, because follow-up for them was unavailable.…”