Primary Cutaneous Mucinous Carcinoma

Kamalpour, Loebat; Brindise, Renata T.; Nodzenski, Michael; Bach, D; Veledar, Emir; Alam, Murad

doi:10.1001/jamadermatol.2013.6006

Cited by 86 publications

(81 citation statements)

References 54 publications

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“…It is slightly more common in men and appears most frequently between the ages of 50 and 70 years [ 3 ]. The prevalence is higher in white patients (77.2%) than in Asians (12.7%) or in African Americans (10.1%) [ 4 ]. We report a case of PCMC of the lower eyelid in a 51-year-old Asian male.…”

Section: Introductionmentioning

confidence: 99%

Primary Cutaneous Mucinous Carcinoma of the Eyelid

Tak

Cho

Kang

et al. 2016

Arch Craniofac Surg

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Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.

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Section: Introductionmentioning

confidence: 99%

Primary Cutaneous Mucinous Carcinoma of the Eyelid

Tak

Cho

Kang

et al. 2016

Arch Craniofac Surg

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“…However, inadequate safety margin is associated with recurrence rates between 20% and 30%. As such, the gold standard of treatment is local wide excision [ 2 ]. In the case presented, the 0.5-cm surgical margin is smaller than in previous reports, in which the skin tumors were resected with the traditional 1-cm surgical margin (ranged from 0.2 to 2.0 cm).…”

Section: Discussionmentioning

confidence: 99%

“…We had few reasons for this smaller margin. First, the primary lesion was a very small nodule (0.6×0.5×0.4 cm), which was a good prognostic factor [ 2 ]. Second, pathologic examination estimated the first specimen to contain clear margin, and intra-operative frozen section was clear even with the small margin.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the age and ethnicity of the patient also portended a favorable prognosis. According to a recent meta-analysis by Kamalpour et al [ 2 ], lower rates of metastasis and recurrence have been reported among younger patients and East Asians. They also reported that head and neck (compared to the trunk) lesions was predictive of a good outcome, which is in contrast to other non-melanomatous skin cancers like squamous cell and basal cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor of eccrine origin with only about 150 cases reported [ 1 2 ]. Clinically, the carcinoma presents as a solitary, slow growing, and painless nodule [ 2 3 ]. For this reason, the lesion is often regarded as a benign mass at the initial presentation.…”

Section: Introductionmentioning

confidence: 99%

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Primary Cutaneous Mucinous Carcinoma Treated with Narrow Surgical Margin

Choi

Kim

et al. 2016

Arch Craniofac Surg

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Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor of eccrine origin. Clinically, the carcinoma presents as a solitary, slow growing, and painless nodule. For this reason, this tumor is often considered to be a benign mass in the preoperative setting. The lesion is, however, malignant in nature and has a tendency for local recurrence and infrequent metastasis. Wide local excision is the treatment of choice. However, few reports exist with information regarding surgical margins and clinical outcomes. Herein, we report a case of PCMC excised with a narrow surgical margin and review the relevant literature. A 49-year-old man presented with a small cutaneous nodule of the right cheek. The mass was excised without any margin, but pathologic examination revealed histology of mucinous carcinoma. Because of this, the operative site was re-excised with a 5-mm margin, and the wound was closed using a V-Y advancement flap. Systemic work-up did not reveal other potential metastatic primary, for a final diagnosis of PCMC. We report this case of PCMC, treated with relatively narrow margin in a patient with good prognostic factors.

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