Primary cutaneous melanoma of the scalp: Patterns of recurrence

Sparks, David S.; Read, Tavis; Lonne, Michael; Barbour, Andrew P.; Wagels, Michael; Bayley, Gerard; Smithers, B. Mark

doi:10.1002/jso.24535

Cited by 20 publications

(23 citation statements)

References 17 publications

(62 reference statements)

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“…79 Tas when the melanoma has already reached a significant thickness. [80][81][82][83] A variety of factors have been incriminated to account for the high local recurrence. These include increased thickness of the primary lesion, inadequate excision margins due to anatomic constraints and unfavorable histology.…”

Section: Role Of Radiotherapymentioning

confidence: 99%

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A brief synopsis on scalp melanoma

Saaiq

Zalaudek

Rao

et al. 2020

Dermatologic Therapy

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Melanoma constitutes one of the most sinister and troublesome malignancies encountered by humanity. Generally, the diagnosis of advanced melanoma connotes a grave prognosis, prompting a sense of looming threat of death, however, the early‐stage detected disease responds well to robust treatment resulting in reasonable survivorship. Scalp melanomas are even more troublesome, because they typically exhibit more aggressive biologic behavior and are often diagnosed at a late stage. This review tries to comprehensively highlight the various diagnostic, therapeutic, and outcome aspects of scalp melanomas. The literature research includes peer‐reviewed articles (clinical trials or scientific reviews). Studies were identified by searching electronic databases (MEDLINE and PubMed) till May 2020 and reference lists of respective articles. Only articles published in English language were included.

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Section: Role Of Radiotherapymentioning

confidence: 99%

“…One probable cause is the late diagnosis, as the scalp region is often covered by hair and hence not easily accessible to self or clinical examination. The first clinical symptoms generally appear when the melanoma has already reached a significant thickness 80‐83 …”

Section: Outcome Of Scalp Melanomasmentioning

confidence: 99%

A brief synopsis on scalp melanoma

Saaiq

Zalaudek

Rao

et al. 2020

Dermatologic Therapy

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“…23 The improved side-effect profile and reproducibility of results has led to the acceptance of ILI as a safe and effective treatment of unresectable melanoma metastases in Australia, where it remains the standard of care. 24 Within the current study, this possible confounder was largely controlled for by the matching process, although three patients had nonextremity-based disease. As an intralesional agent PV-10 can be selected for such patients, although these treatment sites are known to be associated with worse long-term survival outcomes independent of treatment type.…”

Section: Discussionmentioning

confidence: 93%

“…As an intralesional agent PV-10 can be selected for such patients, although these treatment sites are known to be associated with worse long-term survival outcomes independent of treatment type. 24 Within the current study, this possible confounder was largely controlled for by the matching process, although three patients had nonextremity-based disease. In the PV-10 subgroup, the ORR was 83.4% (CR 25.0%; PR 58.4%) and this response profile is similar to other institutional treatment results and data from the phase II study.…”

Section: Toxicitymentioning

confidence: 93%

Patients with in‐transit melanoma metastases have comparable survival outcomes following isolated limb infusion or intralesional PV‐10—A propensity score matched, single center study

Read

Fayers

Thomas

et al. 2019

Journal of Surgical Oncology

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Background and Objective Isolated limb infusion (ILI) and intralesional PV‐10 are well described locoregional therapies for in‐transit melanoma. The objective of this study was to assess the effect of these treatments on survival outcomes within a cohort matched for key characteristics. Methods Patients were treated using ILI or intralesional PV‐10 at a single institution and the data prospectively recorded. Propensity score matching was performed using key covariates within a logistic regression model. The primary outcome was the melanoma‐specific survival. Results Seventy‐two patients nonrandomized were successfully matched. Both treatments produced similar best overall responses. The median melanoma‐specific survival (MSS) was 74.4 months from ILI and 36.4 months from PV‐10 treatments (P = 0.164). Within the ILI subgroup, the 12‐, 24‐, 36‐ and 60‐month MSS rates were 85.3%, 75.3%, 60.1%, and 60.1%, respectively. From the time of PV‐10 the corresponding 12‐, 24‐, 36‐, and 60‐month MSS rates were 82.6%, 70.0%, 53.9%, and 35.9%. On multivariate analysis, there was a significant difference in survival comparing completely with noncomplete responders ( P = 0.031). Conclusions These findings demonstrate that ILI and PV‐10 treatments for in‐transit disease produce comparable long‐term survival. Both therapies have reproducible response rates and predominantly localized and tolerable side‐effects.

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“…Primary melanoma of the scalp represents a unique subcategory with an aggressive phenotype characterized by high rates of local, in-transit metastases, and regional recurrence as well as poor disease-free survival outcomes [7]. It's more likely to be rapidly growing, a melanotic and nodular in subtype.…”

Section: Discussionmentioning

confidence: 99%

Giant Primary Amelanotic Scalp Melanoma: Report of a Rare Case and Review of the Literature

Zinoune¹,

Elloudi²,

Hassani³

et al. 2019

Madridge J Case Rep Stud

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Giant cutaneous malignant melanoma is rarely observed in clinical practice. It has rarely been described in the literature. Melanoma of the scalp with amelanotic character is even rarer, it represents an aggressive subcategory with high rates of in-transit disease and poor disease-related and survival outcomes. In this paper, we document our experience with an elderly patient with a giant amelanotic melanoma of the scalp and review the literature.

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Primary cutaneous melanoma of the scalp: Patterns of recurrence

Cited by 20 publications

References 17 publications

A brief synopsis on scalp melanoma

A brief synopsis on scalp melanoma

Patients with in‐transit melanoma metastases have comparable survival outcomes following isolated limb infusion or intralesional PV‐10—A propensity score matched, single center study

Giant Primary Amelanotic Scalp Melanoma: Report of a Rare Case and Review of the Literature

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