Primary Cutaneous Melanoma Arising in a Long-Standing Irradiated Keloid

Fish, Lindsay M.; Duncan, Lisa; Gray, Keith D.; Bell, John L.; Lewis, James M.

doi:10.1155/2012/165319

Cited by 4 publications

(4 citation statements)

References 15 publications

(15 reference statements)

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“…Benign and malignant melanocytic lesions developing within a keloid scar are rare [ 13 , 14 ]. To add further complexity to the diagnosis, the recurrent nevus phenomenon must be differentiated from reactive melanotic pigmentation in scars [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Nevus Phenomenon Developing within a Keloid

2023

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The recurrent nevus phenomenon represents the persistence of a nevus within a scar from a prior biopsy site, with the acquisition of clinical and histologic features frequently overlapping with those of melanoma, posing relevant diagnostic challenges. Similar features are recognized in nevi that have undergone recent or chronic trauma and in sclerosing nevi. Any type of nevus may be subject to this phenomenon. Keloids are exuberant scars with an exaggerated accumulation of dense dermal collagen. Here we report a case of a 42-year-old woman with the incidental finding of an atypical melanocytic proliferation developing within a keloidal scar. The patient presented with a progressively enlarging auricular lesion three years after a piercing procedure. Upon histological examination, attentive scrutiny of the margin revealed an atypical compound melanocytic proliferation, predominantly single-celled at the junction but occasionally nested, with cytologic atypia and architectural disorder. This atypical proliferation was found emerging above a keloid. We interpreted the lesion as an atypical melanocytic lesion with features resembling the recurrent nevus phenomenon. This case raises awareness in recognizing these melanocytic lesions as benign, thereby avoiding overdiagnosis and unnecessary treatment.

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Section: Discussionmentioning

confidence: 99%

“…Keloids are associated with increased pigmentation, yet there is a severe lack of data supporting melanocyte involvement in keloid development [ 12 ]. Reports of both benign and malignant melanocytic lesions developing within a keloid are scant in the literature [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Recurrent Nevus Phenomenon Developing within a Keloid

2023

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“…Differential diagnoses may present with extensive keloid and/or hypertrophic scarring, multiple-plate morphea, especially nodular and keloid variant; desmoplastic melanoma and scar sarcoidosis [12,13]. Mullinaz and Cohen described a case of a 63-year-old woman with a history of a mammoplasty, who developed lesions like keloids, for which she received numerous treatments with topical steroids and in infiltration, the lesions were located outside the sites of the previous incisions and had little response to the treatments, which led to the performance of biopsies that allowed the diagnosis of a breast cancer, the authors emphasize that the tumor cells can be overlooked due to their similarity in appearance with the fibroblasts [11].…”

Section: Case Discussionmentioning

confidence: 99%

Carcinoma en cuirasse: Reason for Initial Consultation in a Breast Cancer

Ocampo¹,

Londoño²,

Lopera³

2019

Arch Clin Med Case Rep

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Breast cancer in women represents the fifth cause of death in the world and the leading cause of cancer death in Colombia. Cutaneous metastases of this cancer are frequent, 23.9% of the cases, and 3% of them present as a carcinoma in cuirasse with papules and nodules, initially dispersed, which are later grouped into scleroderma-like lesions; Keloid-like lesions are rare. We present the case of a 56-year-old woman with a breast metastasis of a mammary carcinoma with pruritic lesions similar to keloids, from which a hidden breast cancer was diagnosed. In skin histopathology, a fibrotic stroma was found with atypical cells that infiltrated collagen bundles in an "Indian row" pattern, positive for estrogen and progestogen hormone receptors. The patient presented a clinical improvement of skin lesions and symptoms after chemotherapy. The clinical diversity of skin metastases and the importance of suspecting breast cancer from keloid lesions in the anterior thorax are highlighted.

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“…However, long-term safety has not been established and invasive tumor may develop after this regimen. 13 Intralesional steroid injections are probably the most common therapy clinically. Many patients are reluctant to undergo this painful therapy, especially for children and patients with large keloid.…”

Section: Introductionmentioning

confidence: 99%

Portable ultraviolet light A1 light source to treat hypertrophic scar

Huang

et al. 2015

Dermatologica Sinica

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a b s t r a c tBackground/Objectives: Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars. Materials and methods: A light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model. Results: In cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo. Conclusion: These results support the potential of a portable UV-A1 light device in treating hypertrophic scar.

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Primary Cutaneous Melanoma Arising in a Long-Standing Irradiated Keloid

Cited by 4 publications

References 15 publications

Recurrent Nevus Phenomenon Developing within a Keloid

Recurrent Nevus Phenomenon Developing within a Keloid

Carcinoma en cuirasse: Reason for Initial Consultation in a Breast Cancer

Portable ultraviolet light A1 light source to treat hypertrophic scar

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