Primary cutaneous lymphomas: A clinical and histological study of 99 cases in Isfahan, Iran

Abstract

Background:Primary cutaneous lymphomas (PCLs) represent a heterogeneous group of T- and B-cell lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. The aim of this study was to assess and report the epidemiological characteristics of PCLs in Isfahan, Isfahan Province, Iran – as a main province of Iran.Materials and Methods:A total of 99 patients were recruited over a recent 10-year period (2003-2013) with diagnosis of PCLs; the patients were classified according to the The World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) criteria. Mean and standard deviations (SDs) were used to describe continuous data, numbers, and percentages for categorical data. Statistical significance was defined as P < 0.05.Results:The patients comprised 45 men and 54 women aged 5-80 years (median 36) at diagnosis. The male-to-female ratio was 1:1.2. Histological examination showed features of primary cutaneous B-cell lymphomas (PCBCLs) in four cases. The mean ± SD age in primary cutaneous T-cell lymphomas (PCTCLs) and PCBCLs was 37.9 ± 16.5 years and 39.7 ± 9.1 years, respectively (P = 0.72). The mean ± SD latent period between the time of diagnosis and initiation of skin lesions in men and women was 2.3 ± 4.1 years and 5.9 ± 10.1 years, respectively (P = 0.02). The most frequent subtypes were mycosis fungoides (MFs) (86.9%) followed by Sιzary syndrome (SS) (4%). Five patients died from PCL-related deaths.Conclusion:The distinguishing epidemiologic characteristics of PCL in Iran are the absence of a male predominance and a lower age of diagnosis. The study highlights the ethnic or regional variations in the clinicoepidemiological characteristics of PCLs.

Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study

“…Of the 137 PCL patients, we found that the frequency of CTCLs (97.8%) was higher than in most previous studies reported worldwide [ 3 – 6 , 8 – 10 , 14 – 16 ]. This finding is consistent with those reported in studies from China (94.5%) [ 10 ], Iran (96%) [ 17 ], Argentina (93%) [ 16 ], and Taiwan (92.3%) [ 18 ], but relatively higher than those from Japan (85.7%) [ 8 ] and Korea (88%) [ 9 ]. Our study emphasizes that non-Caucasian populations appeared to have a higher proportion of CTCLs than those of Caucasian populations (USA, 72.4% [ 6 ]; Netherlands and Austria, 78% [ 4 ]; Germany, 85% [ 5 ]; Switzerland, 72% [ 15 ]; Italy, 78.7% [ 3 ]).…”

“…In contrast, the incidence of CBCLs (2.2%) was much lower in our study than that reported in studies from Western countries. The median age at diagnosis (40 years) of patients with PCLs overall in our study was younger than those reported in many previous studies, particularly from Western countries such as Switzerland (56 years) [ 15 ] and Italy (64 years) [ 3 ], but was close to those reported in studies from China (44.5 years) [ 10 ] and Iran (36 years) [ 17 ]. This could be explained by a high rate of HMF, a variant particularly affects young adults, in this study.…”

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

“…[10] A similar age trend (<50 years) has also been reported from other Asian countries such as Korea, China, and Iran. [568] A consistent male predominance of more than 2-fold was noted in our study. Males demonstrated an early onset of T-cell lymphomas and females a late onset disease.…”

“…However, a higher percentage of BCLs occurs in Western countries (29%) and other Asian countries such as Japan (13%), Taiwan (26%), and Korea (29%). [345678910]…”

Correlation between mycosis fungoides and pregnancy

“…Mycosis fungoides (MF) is an extra-nodal non-Hodgkin’s lymphoma with primary involvement of the skin. 1 , 2 Mycosis fungoides usually has an indolent course and a good prognosis when identified in its early stages. 3 - 5 The peak age at presentation of the disease is 55-60 years, with a 2:1 male to female ratio in Western countries.…”