Primary cutaneous large B-cell lymphoma of the leg: Histogenetic analysis of a controversial clinicopathologic entity

Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients

“…In normal lymphoid tissue, it is mainly expressed by plasma cells and a subset of germinal center B lymphocytes. MUM-1 expression was found in all cases of cutaneous LBCL of the leg classified according to the first EORTC classification in one study, 20 and in the new WHO/EORTC classification of cutaneous lymphomas it is suggested that MUM-1 expression is found constantly in LBCLLT and is absent in FCLDT. 1 In our study, specificity and sensitivity of MUM-1 expression for diagnosis of LBCLLT were 85.7% and For personal use only.…”

WHO-EORTC classification for cutaneous lymphomas

“…142 Unlike PCFCL, most PCLBCL, leg types, express MUM-1/IRF4 protein ( Figure 10D). 46,168 Genetic features. The t(14;18) is not found in PCLBCLs, although strong bcl-2 expression is common in this group.…”

European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas

“…The CR rate in 101 reported cases was 88% (89 of 101 patients) and the relapse rate was 58% (52 of 89 patients), whereas in-field and marginal recurrences have also been reported. 22,23,26,27,29,30,56,58,87 Extracutaneous progression was reported in approximately 30% of patients.…”