Primary Cutaneous Hodgkin's Disease

Primary Cutaneous Hodgkin's Lymphoma: An Extremely Rare Entity

“…Lesions of primary cutaneous HL have been described as erythematous papules and nodules with or without ulceration, most commonly involving the scalp and cervical region and extremities [9] (Table 1). The immunohistochemical diagnosis of primary cutaneous Hodgkin's disease is difficult, although the detection of neoplastic Reede-Sternberg cells with mirror nuclei, the positivity of CD30 and CD15 activation antigens, and the negativity of CD45 strongly support the diagnosis of Hodgkin's disease [10].There are many other diseases in which Reed-Sternberg cells can be found, including benign thymoma, proliferative myositis, infectious mononucleosis, lymphomatoid papulosis type A, anaplastic large cell lymphoma, and some forms of B-cell lymphoma, particularly cases expressing CD30 or associated with EBV infection and hematopoietic tumors [11][12][13]. In addition, the presence of CD15 is reported in a subset of lymphomatoid papulosis, mycosis fungoides, CD30+ large cell analplastic lymphoma and some T-cell lymphomas [14,15].…”