Primary cutaneous histoplasmosis in an immunocompetent patient presenting with severe pruritus

Patra, Suman; Nimitha, P; Kaul, Subuhi; Valakkada, Jineesh; Verma, Kaushal K.; Ramam, M; Bhari, Neetu

doi:10.4103/ijdvl.ijdvl_695_17

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…Currently, only AmBisome® has been evaluated in the treatment of disseminated histoplasmosis [2,31]. Besides, some case reports have also stressed its clinical efficacy in the rare primary cutaneous form of the disease in immunocompetent patients [9][10][11].…”

Section: Lipid Formulations Of Amphotericin Bmentioning

confidence: 99%

“…The infection is caused by inhaling aerosols that contain the infecting particles of the dimorphic fungus, Histoplasma capsulatum and it affects most frequently the lung [8]. Nevertheless, it can also affect the skin [9][10][11], and the central nervous system (CNS) causing meningitis [12] or even evolve into a progressive disseminated infection that may trigger an inflammatory response and bring rheumatological and heart complications (pericarditis), with high morbidity rates [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Filipa¹,

Domingos²,

Salette³

et al. 2023

Infectious Diseases

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Histoplasmosis is an airborne systemic infection, with varied clinical manifestations, from asymptomatic infection to disseminated disease with a deadly outcome. Due to a growing number of immunosuppressed people, this mycosis has become more prevalent and thus, a cause for concern within the medical community. In fact, this fungal infection can be quite serious for children, elderly, people who have had an organ transplant, HIV-positive or people taking immunosuppressants. There has been a limited number of research articles suggesting polymeric, metallic, or lipid micro and nanotechnology-based approaches as a potential way to carry antifungal drugs to treat histoplasmosis. These new drug delivery systems present a variety of means of administration, thereby allowing a more targeted treatment to the lungs, skin, or eyes, according to the infection site. In this review, the aim was to explore these new therapies that have been emerging which hold great potential in comparison to regular antifungal treatments, not only due to their safety but also due to their drug release profile.

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Section: Lipid Formulations Of Amphotericin Bmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Filipa¹,

Domingos²,

Salette³

et al. 2023

Infectious Diseases

View full text Add to dashboard Cite

show abstract

Cutaneous Histoplasmosis in a Renal Transplant Patient Presenting With Hand and Forearm Necrotizing Myofasciitis

Kozusko¹,

Riccio²,

Minor

et al. 2020

The Journal of Hand Surgery

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Disseminated Histoplasmosis Diagnosed by “Touch Prep”

Kingsley

Clarey²,

Lauer

et al. 2020

The American Journal of Dermatopathology

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Disseminated histoplasmosis is a rare but serious complication of infection with the dimorphic fungus Histoplasma capsulatum. We report a case of disseminated histoplasmosis with cutaneous involvement diagnosed by touch wet preparation and confirmed with histopathology and culture. “Touch prep” performed from a lesional punch biopsy, prepared with Wright-Giemsa followed by chlorazol black containing KOH, revealed abundant yeast organisms localized within multinucleated giant cells, and a rapid diagnosis of disseminated histoplasmosis with cutaneous involvement was achieved. This report demonstrates the utility of wet prep techniques as an invaluable and rapid beside diagnostic tool in the setting of cutaneous histoplasmosis. In addition, we compare the distinguishing histopathologic features of the infectious organisms within the differential diagnosis of parasitized histiocytes.

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Primary cutaneous histoplasmosis in an immunocompetent patient presenting with severe pruritus

Cited by 7 publications

References 4 publications

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Cutaneous Histoplasmosis in a Renal Transplant Patient Presenting With Hand and Forearm Necrotizing Myofasciitis

Disseminated Histoplasmosis Diagnosed by “Touch Prep”

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