Primary cutaneous cryptococcosis following trauma of the right forearm

Bohne, T.; Sander, Anna; Pfister-Wartha, Andrea; Schöpf, Erwin

doi:10.1111/j.1439-0507.1996.tb00097.x

Cited by 19 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, during the past years, it became obvious that local cutaneous infections by C. neoformans may occur without any simultaneous systemic infection [15][16][17][18]. Neuville et al [10] have proposed criteria to distinguish primary and secondary cutaneous cryptococcosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Cryptococcosis and Secondary Antigenemia in a Patient with Long-Term Corticosteroid Therapy

et al. 2005

View full text Add to dashboard Cite

We report a case of a 71-year-old male who developed severe cellulitis of his right forearm and hand after he had an accidental injury from the sharp edge of a metal plate of a birdhouse. The patient suffers from chronic asthma and has been treated with systemic corticosteroids for years. Culture of aspirates from two sites of the wound area revealed growth of Cryptococcus neoformans in one and Acinetobacter lwoffii in the other. After combined treatment including antibiotics, antifungal therapy with fluconazole 400 mg/d and surgical debridement followed by a mesh graft, the patient achieved complete healing of the wound. Five months after the infection, the patient was still positive for cryptococcal antigen at a titer of 1:64 despite oral treatment with fluconazole 50 mg/d, and maintenance therapy with fluconazole 200 mg/d was recommended for 6 months, or longer depending on further results. The clinical and microbiological characteristics of this patient as well as therapeutical and epidemiological aspects of primary cutaneous cryptococcosis (PCC) are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Cryptococcosis and Secondary Antigenemia in a Patient with Long-Term Corticosteroid Therapy

et al. 2005

View full text Add to dashboard Cite

show abstract

“…13 Cryptococcosis, as an opportunistic T cell modulated mycosis, is an important disease in patients with a weak or suppressed immune system. 7 It is a major cause of fungal meningitis and is often seen in patients with AIDS. 14 However, cryptococcal meningitis can occur in immunocompetent hosts.…”

Section: Discussionmentioning

confidence: 99%

Cryptococcal meningitis in an HIV negative patient with systemic sarcoidosis.

Botha

Wessels

1999

J Clin Pathol

View full text Add to dashboard Cite

A case of Cryptococcus neoformans meningitis is described in an HIV negative patient with undiagnosed systemic sarcoidosis. The patient presented with signs of meningitis together with generalised lymphadenopathy and hepatosplenomegaly. Cryptococcal meningitis was diagnosed on lumbar puncture. She was treated with intravenous amphotericin B but died within two weeks of admission. Necropsy revealed lesions in the lungs, liver, spleen, lymph nodes, small intestine, and bone marrow consistent with sarcoidosis. Microscopically the lesions contained non-caseating epithelioid cell granulomas typical of sarcoidosis. No Schaumann or Hamazaki-Wesenberg bodies were identified. Cryptococcus neoformans meningitis is generally associated with immunosuppressive disorders. As T cell abnormalities have been described in sarcoidosis, this could have been a case of opportunistic infection. Although rare, sarcoidosis merits consideration in patients with cryptococcal disease in the absence of HIV infection. (J Clin Pathol 1999;52:928-930)

show abstract

“…C. neoformans is an encapsulated, spherical yeast fungus with five serotypes and two varieties: serotypes A (99% cases), 1 D and AD are the neoformans variety, an opportunistic fungus that causes systemic disease in immunocompromised patients; serotypes B and C constitute the gattii variety, 2 a pathogenic fungus that usually affects immunocompetent hosts living in a rural or outer urban regions 3 . This fungus can be isolated from spoiled fruit, soil, grasses and cereals.…”

Section: Reportmentioning

confidence: 99%

Primary cutaneous cryptococcal cellulitis secondary to insect bite in an immunosupressed patient after liver transplantation

2005

View full text Add to dashboard Cite

Cutaneous cryptococcosis is usually a manifestation of disseminated disease, especially in immunosuppressed patients. Primary cutaneous cryptococcosis has also been described in some patients without evidence of systemic disease. Distinguishing between primary and secondary cutaneous cryptococcosis may be difficult as patients can be asymptomatic or cutaneous lesions may precede systemic involvement by some months. Features supporting primary disease are a history of cutaneous inoculation, and solitary superficial lesions on uncovered parts of the body. We present a liver transplant patient with cutaneous cryptococcal cellulitis subsequent to an insect bite, without systemic involvement and with excellent response to treatment with amphotericin B for 15 days and surgical debridement plus oral fluconazole for 3 months. In immunosupressed patients with cellulitis a cryptococcal infection must be excluded. If cutaneous cryptococcosis is diagnosed, systemic evaluation and prompt lengthy treatment are required.

show abstract

Primary cutaneous cryptococcosis following trauma of the right forearm

Cited by 19 publications

References 19 publications

Primary Cutaneous Cryptococcosis and Secondary Antigenemia in a Patient with Long-Term Corticosteroid Therapy

Primary Cutaneous Cryptococcosis and Secondary Antigenemia in a Patient with Long-Term Corticosteroid Therapy

Cryptococcal meningitis in an HIV negative patient with systemic sarcoidosis.

Primary cutaneous cryptococcal cellulitis secondary to insect bite in an immunosupressed patient after liver transplantation

Contact Info

Product

Resources

About