Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: Case series at the Semmelweis University, Department of Dermatology, Venereology and Dermatooncology and review of the literature

Abstract

In the updated 2018 WHO-EORTC classification, the name of the disease was changed to primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder instead of the former primary cutaneous CD4+ small/medium T-cell lymphoma, because of its indolent behaviour and uncertain malignant potential. The authors present five cases of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder, through which they show the various clinical appearances, and the histological features of the disease, and review the literature. The authors point out that the disease, except for a few cases, presented with a solitary lesion, has a particularly good prognosis, remains localized and shows a tendency to regress despite the monoclonal T-cell receptor gene rearrangement.