Primary Cutaneous CD30+ Lymphoproliferative Disorders

Adult pityriasis lichenoides‐like mycosis fungoides: a clinical variant of mycosis fungoides

“…As with PL, LyP consists of a spectrum of lesions that may be clinically indistinguishable from PL in a given case. Four types of LyP are distinguished (A, B, C, and D) according to the type and distribution of the lymphocytic infiltrate . It is particularly important to establish a differential diagnosis with type B (or MF‐like), which is characterized by atypical lymphocytes with hyperchromatic cerebriform nuclei, because the histological features may be identical.…”

Benign Atypical Intravascular CD30+ T-cell Proliferation

“…5 The presence of CD30 + lymphocytes in the skin may occur as result of a reactive process (CD30 + pseudolymphomas), as a primary CD30 + LPD, as a transformation of mycosis fungoides to large cell lymphomas, or as a cutaneous involvement of nodal lymphomas. 10 Primary cutaneous CD30 + LPD is the most common group of cutaneous T-cell lymphomas after mycosis fungoides. Inflammatory diseases and cutaneous infections, including pityriasis lichenoides et varioliformis acuta, atopic dermatitis, reaction to drugs, viral and mycotic infections, mycobacteriosis, and scabiosis, may contain a significant number of CD30 + T cells and may be clinically and histologically considered inflammatory reactive processes.…”

“…6 The term CD30 + pseudolymphoma is proposed to designate a reactive process that can simulate LPDs. 10 The final diagnosis of CD30 + LPD is based on a synthesis of clinical, histological, and molecular genetic findings. [7][8][9] These conditions, usually, show small/medium CD30 + T lymphocytes in lower numbers than in LPD but with no monoclonal rearrangement of the T cell receptor.…”

Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal

“…Lymphomatoid papulosis (LyP), categorized as a primary cutaneous CD30‐positive lymphoproliferative disorder under the current World Health Organization‐European Organization for Research and Treatment of Cancer (WHO‐EORTC) classification of cutaneous lymphomas, is characterized clinically by spontaneously arising and resolving papulonodules . Lesions, which are less than 2 cm in diameter and may be grouped or disseminated, occur predominantly on the trunk and limbs, often ulcerate, and resolve within 3 to 12 weeks typically leaving behind superficial varioliform scars . The disease may be present for several months to more than 40 years with an overall good prognosis .…”

“…2,3 The disease may be present for several months to more than 40 years with an overall good prognosis. 1,3 However, in up to 20% of patients, the diagnosis of LyP may be preceded by, associated with, or followed by another lymphoproliferative disease, usually mycosis fungoides (MF), anaplastic large cell lymphoma (ALCL) or Hodgkin lymphoma. 4 Histopathologically, LyP shows an intradermal infiltrate of large atypical CD30-positive lymphocytes.…”