Primary cutaneous CD30+ lymphoproliferative disorder in an atopic dermatitis patient on cyclosporine therapy

Takeda, Kazuya; Hashimoto, Y; Mizumoto, Toshihiro; Ishida‐Yamamoto, Akemi; Iizuka, Hajime

doi:10.4103/0378-6323.77496

Cited by 10 publications

(12 citation statements)

References 5 publications

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“…Although not observed by us, several cases of pcALCL occurring in patients with atopic dermatitis have been reported, often in the context of cyclosporine therapy given for the atopic dermatitis. [13,14] In agreement with our previous study, [2] IgE-t GM values of supplemental patients progressively increased from LyP-B to LyP-A to LyP-C, and with increasing categories of CD30 + dermal cells below 50% in the skin specimen obtained at the time of blood sampling. This observation suggests that the atypical CD30+ cells might be influencing IgE production.…”

Section: Discussionsupporting

confidence: 91%

Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder

2020

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BackgroundPrimary cutaneous CD30+ lymphoproliferative disorders (CD30CLPD) are the second most common type of cutaneous T cell lymphoma (CTCL) and include lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL). Case reports and small patient series suggest an association of CD30CLPD with atopic disorders. However, the prevalence of atopy in patients with CD30CLPD in retrospective studies depends on patients' recall which is not always reliable. More objective criteria of atopy include evidence of skin reactivity to allergens (positive prick test) and evidence of allergen-specific IgE in serum. This study was undertaken to test the hypothesis that atopy is prevalent in patients with CD30CLPD using serologic criteria of allergen-specific IgE antibodies to aeroallergens and Staphylococcal aureus enterotoxin superantigens (SSAgs). MethodsWe tested serum samples of CD30CLPD for common IgE-specific airborne allergens with the Phadiatop test, which if positive, is regarded as serologic evidence of atopy in adults. Sera were also tested for IgE antibodies reactive to three Staphylococcal enterotoxins with superantigenic properties (SSAg-IgE). Control sera were obtained from adult subjects evaluated for rhino-sinusitis and a negative Phadiatop test. Patients' history of an atopic disorder was obtained by retrospective chart review.

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Section: Discussionsupporting

confidence: 91%

Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder

2020

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“…renal dysfunction) in older adults. 76 Narrowband ultraviolet B at a dose of approximately 0.35-0.65 J/cm 2 per irradiation appears extremely effective for elderly AD. 77,78 Therapeutic patient education 79 and a psychodermatological approach 80 are also useful for avoiding trigger factors and modifying problematic behaviors, such as habitual scratching.…”

Section: Managementmentioning

confidence: 97%

“…As other adjunctive treatments, oral cyclosporine is very effective for the treatment of severe cases of elderly AD, but clinicians must pay attention to the increased risk of malignancy and organ toxicity (e.g. renal dysfunction) in older adults . Narrowband ultraviolet B at a dose of approximately 0.35–0.65 J/cm 2 per irradiation appears extremely effective for elderly AD .…”

Section: Diagnosis and Management Of Elderly Admentioning

confidence: 99%

Atopic dermatitis in older adults: A viewpoint from geriatric dermatology

Tanei

Hasegawa

2016

Geriatrics Gerontology Int

120

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Atopic dermatitis (AD) in older adults represents a newly defined subgroup of AD. The prevalence of elderly AD is approximately 1-3% among elderly populations in industrialized countries. Elderly patients with AD show some common clinical characteristics, such as a male predominance, a lower incidence of lichenified eczema at the elbow and knee folds, and particular patterns of onset and clinical course. Both immunoglobulin (Ig)E-allergic and non-IgE-allergic types are observed in elderly AD. Elderly patients with IgE-allergic AD show high rates of positivity for specific IgE antibodies against house dust mites, associations with IgE allergic and asthmatic complications, histopathological features with a predominance of IgE-mediated allergic inflammation in the lesional skin, and a significantly lower incidence of malignancy as compared with control subjects. The etiology of elderly AD might be associated with immunosenescence, age-related changes to the sex hormone milieu, age-related barrier dysfunctions in the skin and gut, functional disturbance of sweat production, and environmental stimuli in the lifestyle of elderly individuals. Powerful anti-inflammatory treatments, such as oral corticosteroids, might be required together with standard treatments to manage moderate to severe cases of elderly AD. Finally, most elderly patients with AD reach the end of life with this disease, which should now be considered a lifelong allergic disease. Geriatr Gerontol Int 2016; 16 (Suppl. 1): 75-86.

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“…She had been diagnosed with AD in early childhood and had been suffering from it ever since. Cyclosporine arguably increases the risk of developing lymphoma [1,[3][4][5][6] and ALCL occurrence has been reported in a psoriatic patient treated with cyclosporine [8]. From age 32, she had repeatedly developed multiple small nodules on her scalp, face, trunk, and extremities.…”

Section: Atopic Dermatitis With Cd30-positive Anaplastic Large Cell Lmentioning

confidence: 99%

“…Platelet activation may be a link in the pathophysiology of diseases prone to thrombosis and inflammation [3]. Elevation of MPV values has been shown to be an independent risk factor in acute myocardial infarction, hyperlipidemia and diabetes mellitus [5,6]. Elevation of MPV values has been shown to be an independent risk factor in acute myocardial infarction, hyperlipidemia and diabetes mellitus [5,6].…”

Section: Mean Platelet Volume Variation After Biologic Therapy In Psomentioning

confidence: 99%

Atopic dermatitis with CD30-positive anaplastic large cell lymphoma

Yasukochi

Takenaka

Yurino

et al. 2014

European Journal of Dermatology

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Primary cutaneous CD30+ lymphoproliferative disorder in an atopic dermatitis patient on cyclosporine therapy

Cited by 10 publications

References 5 publications

Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder

Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder

Atopic dermatitis in older adults: A viewpoint from geriatric dermatology

Atopic dermatitis with CD30-positive anaplastic large cell lymphoma

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