Primary cutaneous B-cell lymphoma is associated with somatically hypermutated immunoglobulin variable genes and frequent use of VH1-69 and VH4-59 segments

Perez, Marie; Pacchiarotti, Arianna; Frontani, Marina; Pescarmona, Edoardo; Caprini, Elisabetta; Lombardo, Giuseppe; Russo, Giandomenico; Faraggiana, Tullio

doi:10.1111/j.1365-2133.2009.09576.x

Cited by 27 publications

(16 citation statements)

References 44 publications

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“…This observation contrasts with the concept that MALT lymphoma is derived from postgerminal center memory B cells [1]. It has been reported that MALT lymphomas of the stomach [12], ocular adnexae [20], and skin [21] usually possess mutated VH genes. However, frequently unmutated genes have been reported in salivary [18] and thymic [19] MALT lymphomas as well as splenic marginal zone lymphoma [23].…”

Section: Discussioncontrasting

confidence: 48%

“…This suggests that there may be no specific antigen that plays a role in the development of pulmonary MALT lymphoma. In contrast, restricted usage of the VH fragment has often been observed in MALT lymphomas at various other sites including the stomach (VH3-30 or VH3-23) [12], salivary gland (VH1-69) [18], thymus (VH3-30 or VH3-23) [19], ocular adnexae (VH1-2 or VH4-34) [20], and skin (VH1-69 or VH4-59) [21]. Many of these MALT lymphomas show an associations with a distinctive chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma

et al. 2011

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma

et al. 2011

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“…Despite the clonal origin of the disease, a LSA specific immunosignature was identifiable. In humans, certain variable region genes are prevalent in LSA [32–34] and superantigens are LSA associated [35], raising the possibility that the immunosignature is that of a causal immunological insult. Proteomic studies in humans have identified distinct protein expression profiles that are informative not only for LSA, but clinical subtype [36, 37].…”

Section: Discussionmentioning

confidence: 99%

The immunosignature of canine lymphoma: characterization and diagnostic application

2014

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BackgroundCancer diagnosis in both dogs and humans is complicated by the lack of a non-invasive diagnostic test. To meet this clinical need, we apply the recently developed immunosignature assay to spontaneous canine lymphoma as clinical proof-of-concept. Here we evaluate the immunosignature as a diagnostic for spontaneous canine lymphoma at both at initial diagnosis and evaluating the disease free interval following treatment.MethodsSera from dogs with confirmed lymphoma (B cell n = 38, T cell n = 11) and clinically normal dogs (n = 39) were analyzed. Serum antibody responses were characterized by analyzing the binding pattern, or immunosignature, of serum antibodies on a non-natural sequence peptide microarray. Peptides were selected and tested for the ability to distinguish healthy dogs from those with lymphoma and to distinguish lymphoma subtypes based on immunophenotype. The immunosignature of dogs with lymphoma were evaluated for individual signatures. Changes in the immunosignatures were evaluated following treatment and eventual relapse.ResultsDespite being a clonal disease, both an individual immunosignature and a generalized lymphoma immunosignature were observed in each dog. The general lymphoma immunosignature identified in the initial set of dogs (n = 32) was able to predict disease status in an independent set of dogs (n = 42, 97% accuracy). A separate immunosignature was able to distinguish the lymphoma based on immunophenotype (n = 25, 88% accuracy). The individual immunosignature was capable of confirming remission three months following diagnosis. Immunosignature at diagnosis was able to predict which dogs with B cell lymphoma would relapse in less than 120 days (n = 33, 97% accuracy).ConclusionWe conclude that the immunosignature can serve as a multilevel diagnostic for canine, and potentially human, lymphoma.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2407-14-657) contains supplementary material, which is available to authorized users.

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“…A t(12;21)(q13;q22) has been detected in one patient [38]. Gene expression studies using cDNA microarrays revealed that cases of cutaneous follicle center lymphoma have a germinal center cell signature [39,40] and show hypermutated immunoglobulin variable genes with frequent use of the VH1-69 and VH4-59 segments [41].…”

Section: Molecular Geneticsmentioning

confidence: 99%

Cutaneous Follicle Center Lymphoma

2014

Skin Lymphoma

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Primary cutaneous B-cell lymphoma is associated with somatically hypermutated immunoglobulin variable genes and frequent use of VH1-69 and VH4-59 segments

Abstract: Data indicate that neoplastic B cells of PBCBL have experienced germinal centre reaction and also suggest that the involvement of IgVH genes is not entirely random in PCBCL and that common antigen epitopes could be pathologically relevant in cutaneous lymphomagenesis.

Cited by 27 publications

References 44 publications

Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma

Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma

The immunosignature of canine lymphoma: characterization and diagnostic application

Cutaneous Follicle Center Lymphoma

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