Primary Cutaneous B-Cell Lymphoma in a Child

Abstract

Primary cutaneous B-cell lymphoma is a B-cell lymphoma of the skin with no evidence of extracutaneous involvement at the time of diagnosis. In this report, we describe an 8-year-old boy who presented with a firm, alopecic, skin-colored, smooth nodule over the right frontal scalp. Histological examination revealed a mid-to deep-dermal mononuclear lesion. Immunohistochemical staining revealed a B-cell population that was CD10(+), CD5(-), CD21(+), and bcl2(-). This pattern of reactivity is characteristic of primary cutaneous B-cell lymphoma of follicle-center subtype. To the best of our knowledge, this is the first report of this type of cutaneous lymphoma in a child.

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

“…249 Armitay-Laish et al 234 reported the occurrence of a spindle cell variant of PCFCL in a 17year-old adolescent girl. Condarco et al 250 reported another case of PCFCL in the scalp of an 8-year-old boy. In the large series (n ¼ 69) of pediatric cutaneous NHL from Gratz, a single case of a PCFCL in a 20year-old individual has been reported.…”

“…Condarco et al. 250 reported another case of PCFCL in the scalp of an 8-year-old boy. In the large series (n = 69) of pediatric cutaneous NHL from Gratz, a single case of a PCFCL in a 20-year-old individual has been reported.…”

Primary Cutaneous Lymphomas in Children and Adolescents

“…Condarco et al. reported the only pediatric case with PCFCL, successfully treated with surgical resection …”

Paediatric primary cutaneous marginal zone B-cell lymphoma: does it differ from its adult counterpart?

“…In the paediatric/adolescent age group, the most common cutaneous lymphomas, as in adults, are primary cutaneous T‐cell lymphomas, mainly juvenile mycosis fungoides . Only 25 cases of PCBCL in patients aged 20 years or younger have been reported, 21 with PCMZL, all of whom were at least 11 years old at diagnosis, and four with PCFCL . The findings of these reports suggested that the presentation and course of PCMZL were similar in adolescents and adults, with excellent prognosis .…”