Primary Cutaneous B-Cell Lymphoma Co-Existing with Mycosis Fungoides—A Case Report and Overview of the Literature

Chilom, Doriana Sorina; Farcaș, Simona Sorina; Andreescu, Nicoleta

doi:10.3390/life12122067

Cited by 1 publication

(1 citation statement)

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“…The emergence of a new lymphoma in a patient with a pre-existing malignancy is a known phenomenon in the setting of immunosuppression. Several cases have reported composite lymphomas, a combination of two different B-cell or T-cell lymphomas, or concomitant B-cell and T-cell lymphomas in this population ( 45 , 46 ). It is also possible for primary lymphomas to metastasize many years after initial diagnosis ( 47 ).…”

Section: Utility Of Immunosequencing In Skinmentioning

confidence: 98%

Immunosequencing applications in cutaneous T-cell lymphoma

Mandel,

Gleason,

Joffe

et al. 2023

Front. Immunol.

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Immunosequencing has emerged as a newer clinical test for assessment of T-cell clonality in the blood and skin of cutaneous T-cell lymphoma (CTCL) patients. Utilization of immunosequencing, also known as high-throughput sequencing of the T-cell receptor (HTS-TCR), enables identification and quantification of the precise genetic signature of dominant T-cell clones. Although immunosequencing is more sensitive than commonly used methods such as polymerase chain reaction (PCR) paired with capillary electrophoresis or flow cytometry, it remains underutilized for CTCL management. Nonetheless, incorporation of HTS-TCR in clinical practice offers distinct advantages compared to other molecular analyses that may improve diagnostic evaluation, prognostication, and disease monitoring in CTCL. The objective of this comprehensive review is to provide a thorough explanation of the application of immunosequencing in the context of CTCL. We describe the significance of T-cell clonality and the methods used to detect it, including a detailed comparison between PCR paired with capillary electrophoresis and HTS-TCR. The utilization of immunosequencing in the blood and skin of CTCL patients is discussed in depth, specifically outlining how HTS-TCR can assist in diagnosing CTCL, predicting outcomes, and tracking disease progression. Finally, we address the potential applications of immunosequencing in clinical management and research as well as the novel challenges it presents.

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Section: Utility Of Immunosequencing In Skinmentioning

confidence: 98%