Primary cutaneous Aspergillus ustus infection: Second reported case

Ricci, Rita M.; Evans, James S.; Meffert, Jeffrey J.; Kaufman, Leo; Sadkowski, Lee

doi:10.1016/s0190-9622(98)70460-8

Cited by 27 publications

(18 citation statements)

References 7 publications

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“…Higher itraconazole MICs were obtained for all A. ustus strains, even after 24 h of incubation, by the Etest method, although the MICs obtained by the NCCLS method were much lower. Since aspergillosis caused by this species has previously been reported to be refractory to itraconazole treatment (14,33,39), the Etest method might detect itraconazoleresistant A. ustus strains better than the NCCLS method does. In the case of A. terreus, even though the MICs for all five strains were similar by the NCCLS method (0.5 to 1 mg/liter), two strains were differentiated by the Etest method, with the MICs for the two strains being threefold lower those for the other three strains.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Etest and the Sensititre Colorimetric Methods with the NCCLS Proposed Standard for Antifungal Susceptibility Testing of Aspergillus Species

et al. 2002

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The susceptibilities of 25 clinical isolates of Aspergillus fumigatus, A. flavus, A. terreus, A. nidulans, and A. ustus to itraconazole and amphotericin B were determined by an agar diffusion-dilution method (the Etest method) and a colorimetric broth microdilution method (the Sensititre method); and the results were compared with those obtained by the NCCLS proposed standard M-38P method for antifungal susceptibility testing of filamentous fungi. Various MIC endpoints for the three methods were determined visually by four different observers in three blinded experiments, and the reproducibilities among the observers (interobserver agreement) and among the replicates (interexperimental agreement) as well as the levels of agreement between the NCCLS, the Etest, and the Sensititre methods were calculated. High levels of reproducibility (within 1 twofold dilution) were found for the NCCLS method (>95%) with the MIC-0 endpoint (complete inhibition of growth) for both drugs and with the MIC-1 endpoint (slight growth) for itraconazole and for the Sensititre method (>90%) with all MIC endpoints, although for the latter the interexperimental agreement for itraconazole was comparatively lower (83 to 93%). The Etest method was less reproducible (67 to 87%) for both drugs. Using the recommended MIC endpoints, high levels of agreement (within one twofold dilution) between the NCCLS and the Sensititre methods for all species were found for amphotericin B (>77%) but not for itraconazole (<66%), for which the MICs by the Sensititre method were up to 3 twofold dilutions lower than the corresponding MICs by the NCCLS method. The use of the first blue well as an endpoint for the Sensititre method and 48 h of incubation improved the levels of agreement with the NCCLS method. Low levels of agreement between the NCCLS and the Etest methods using the recommended MIC endpoints were found for most species, especially after 48 h of incubation (<50%), when the MICs obtained by the Etest method were up to 9 twofold dilutions higher than the corresponding MICs obtained by the NCCLS method. Relatively better agreement was found after 24 h, although it was species dependent, with the highest levels of agreement (>82%) found for A. terreus and A. ustus for amphotericin B and A. fumigatus for both drugs. Overall, better agreement was found when MIC-0 was used as the MIC endpoint for the NCCLS method for both drugs and when the MICs by the Etest method were determined after 48 h of incubation for itraconazole and after 24 h of incubation for amphotericin B.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Etest and the Sensititre Colorimetric Methods with the NCCLS Proposed Standard for Antifungal Susceptibility Testing of Aspergillus Species

et al. 2002

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“…Cutaneous aspergillosis can also arise from an adjacent affected tissue such as the sinus. A. flavus is most often associated with primary cutaneous aspergillosis [94]. It has been reported in diabetic patients and apparently immunocompetent persons [95].The lesions are usually distributed over areas of terminal circulation such as the limbs [96].Aspergillus can also cause dermatitis in premature new-borns [97]; it also invades burns and surgical wounds [3].…”

Section: Chronicmentioning

confidence: 99%

Spectrum of aspergillosis: Pathogenesis, risk factors and management

Iyalla¹

2015

Af J Clin Exp Micro

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This article reviews comprehensively the spectrum of diseases (aspergillosis) caused by Aspergillus spp, the commonest pathogenic form being the A.fumigatus. Aspergilus spp are ubiguitous in the environment and the respiratory tract is the portal of entry in most cases. Aspergillosis is associated with significant mortality and morbidity, the prevalence appears to be on the increase. About 10million people are at risk of aspergillosis, and 50% would die even with treatment. Immunodeficiency, especially neutropenia is central to the pathogenesis of aspergillosis. Diseases caused by A. fumigatus include;1) Invasive aspergillosis seen mostly in stem cell and organ transplant recipients, patients with haematological malignancies, cancer patients on chemotherapy and patients with AIDS. Invasive aspergillosis is life threatening, it affects the lungs and sinuses but could disseminate to affect the CNS, eye, skin and kidney.

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“…ustus is a rarely described Aspergillus species. However, a number of recent reports have documented human infection with this fungus [63][64][65][66][67][68][69][70]. On malt extract agar, A. ustus colonies are dense, cottony, brownish grey, white at the periphery, with a yellow diffusing pigment.…”

Section: U T a N E O U S I N F E C T I O N D U E T O A S P E R G I mentioning

confidence: 99%

New clinical presentations of invasive aspergillosis in non-conventional hosts

Paterson

2004

Clinical Microbiology and Infection

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Infections by Aspergillus spp. are most typically associated with invasive pulmonary aspergillosis. However, an increasing number of reports deal with unusual manifestations of invasive aspergillosis. In the lung this may take the form of chronic invasive pulmonary aspergillosis, bronchocentric granulomatosis or tracehobronchitis. A number of extrapulmonary infections have been noted, sometimes in immunocompetent individuals. Examples include vertebral osteomyelitis, primary cutaneous aspergillosis (such as in premature neonates), prosthetic vascular graft infection and infective endocarditis. Early recognition of these entities, prompt initiation of new, highly active antifungal therapies and adjunctive surgical management may improve the prognosis of these conditions.

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Primary cutaneous Aspergillus ustus infection: Second reported case

Cited by 27 publications

References 7 publications

Comparison of the Etest and the Sensititre Colorimetric Methods with the NCCLS Proposed Standard for Antifungal Susceptibility Testing of Aspergillus Species

Comparison of the Etest and the Sensititre Colorimetric Methods with the NCCLS Proposed Standard for Antifungal Susceptibility Testing of Aspergillus Species

Spectrum of aspergillosis: Pathogenesis, risk factors and management

New clinical presentations of invasive aspergillosis in non-conventional hosts

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