Primary Cutaneous Aspergillosis in a Patient with CARD9 Deficiency and Aspergillus Susceptibility of Card9 Knockout Mice

Zhang, Yi; Huang, Chen; Song, Yinggai; Ma, Yubo; Wan, Zhe; Zhu, Xuejun; Wang, Xiaowen; Li, Ruoyu

doi:10.1007/s10875-020-00909-0

Cited by 19 publications

(37 citation statements)

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“…Curiously, the taxonomy of the producer organisms of this important drug template has not been revised to date, and there is no other report on the discovery of myriocin from another member of the genus Isaria and allies, even though these fungi have been studied rather thoroughly during the past decades (Isaka et al 2005 ; Zhang et al 2020a , b , c , d ).…”

Section: Fingolimod a Drug Derived By Mimetic Synthesis From A Fungal...mentioning

confidence: 99%

Ten decadal advances in fungal biology leading towards human well-being

et al. 2022

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Fungi are an understudied resource possessing huge potential for developing products that can greatly improve human well-being. In the current paper, we highlight some important discoveries and developments in applied mycology and interdisciplinary Life Science research. These examples concern recently introduced drugs for the treatment of infections and neurological diseases; application of –OMICS techniques and genetic tools in medical mycology and the regulation of mycotoxin production; as well as some highlights of mushroom cultivaton in Asia. Examples for new diagnostic tools in medical mycology and the exploitation of new candidates for therapeutic drugs, are also given. In addition, two entries illustrating the latest developments in the use of fungi for biodegradation and fungal biomaterial production are provided. Some other areas where there have been and/or will be significant developments are also included. It is our hope that this paper will help realise the importance of fungi as a potential industrial resource and see the next two decades bring forward many new fungal and fungus-derived products.

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Section: Fingolimod a Drug Derived By Mimetic Synthesis From A Fungal...mentioning

confidence: 99%

Ten decadal advances in fungal biology leading towards human well-being

et al. 2022

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“…CARD9 mutations are autosomal recessive, and homozygous mutations are the most pathogenic; complex heterozygous mutations have also been reported. At present, it is known that patients with CARD9 gene mutation are prone to fungal infection, and the common pathogens are Candida, Aspergillus, and dermatophytes (20)(21)(22).There have been no reports of CARD9 mutation in patients with TM infection.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Talaromyces marneffei Infection in a Chinese Child With a Complex Heterozygous CARD9 Mutation

Peng

et al. 2021

Front. Immunol.

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Talaromyces marneffei (TM) infection is rarely seen in clinical practice, and its pathogenesis may be related to deficiency in antifungal immune function. Human caspase recruitment domain-containing protein 9 (CARD9) is a key molecule in fungal immune surveillance. There have been no previous case reports of TM infection in individuals with CARD9 gene mutations. Herein, we report the case of a 7-month-old Chinese boy who was admitted to our hospital with recurring cough and fever with a papular rash. A blood culture produced TM growth, which was confirmed by metagenomic next-generation sequencing. One of the patient’s sisters had died of TM septicaemia at 9 months of age. Whole exome sequencing revealed that the patient had a complex heterozygous CARD9 gene mutation with a c.1118G>C p.R373P variation in exon 8 and a c.610C>T p.R204C variation in exon 4. Based on the culture results, voriconazole antifungal therapy was administered. On the third day of antifungal administration, his temperature dropped to within normal range, the rash gradually subsided, and the enlargement of his lymph nodes, liver, and spleen improved. Two months after discharge, he returned to the hospital for a follow-up examination. His general condition was good, and no specific abnormalities were detected. Oral voriconazole treatment was continued. Unexplained TM infection in HIV-negative individuals warrants investigation for immune deficiencies.

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“…In the era of the COVID-19 pandemic, invasive pulmonary aspergillosis (IPA) has been shown to develop after COVID-19 infection, and the global impact of Aspergillus infection indicates that this is an important issue, particularly for patients with underlying pulmonary disease [34]. CPA belongs within a spectrum of diseases that occur after Aspergillus infection with immune deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…CPA belongs within a spectrum of diseases that occur after Aspergillus infection with immune deficiency. In primary immune deficiency syndromes [13,14,16,17,34], a lack of a proinflammatory reaction and dysfunction of T helper and T regular cells can lead to suboptimal IFN-γ or TNF-α expression.…”

Section: Discussionmentioning

confidence: 99%

Chronic Pulmonary Aspergillosis: Disease Severity Using Image Analysis and Correlation with Systemic Proinflammation and Predictors of Clinical Outcome

Huang

Chou

et al. 2021

JoF

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(1) Background: The presentation of chronic pulmonary aspergillosis (CPA) ranges from single granuloma to fibrosis in the affected lung. CPA can be divided into five categories according to European Respirology Society (ERS) guidance but is usually assessed by clinical physicians. Computer-based quantitative lung parenchyma analysis in CPA and its correlation with clinical manifestations, systemic inflammation, and angiogenesis have never been investigated. (2) Method: Forty-nine patients with CPA and 36 controls were prospectively enrolled. Pulmonary function tests (forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and FEV1/FCV) and biomarkers in the peripheral blood (the chemokines interleukin (IL)-1B, IL-6, IL-10, IL-8, CRP, ESR, MMP1, MMP7, MMP8, TNF-α, calprotectin, SDF-1α, and VEGFA) were measured before antifungal treatment. The disease severity was categorized into mild, moderate, and severe based on chest computed tomography (CT) images. The oxygen demand and overall mortality until the end of the study were recorded. Quantitative parenchyma analysis was performed using the free software 3Dslicer. (3) Results: The results of quantitative parenchyma analysis concorded with the visual severity from the chest CT, oxygen demand, FVC, and FEV1 in the study subjects. The decrease in kurtosis and skewness of the lung density histograms on CT, increase in high attenuation area (HAA), and reduced lung volume were significantly correlated with increases in the PMN %, CRP, IL-1B, SDF-1α, MMP1, and Calprotectin in peripheral blood in the multivariable regression analysis. TNF-α and IL-1B at study entry and the CPA severity from either a visual method or computer-based evaluation were predictors of long-term mortality. (4) Conclusion: The computer-based parenchyma analysis in CPA agreed with the categorization on a visual basis and was associated with the clinical outcomes, chemokines, and systemic proinflammation profiles.

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Primary Cutaneous Aspergillosis in a Patient with CARD9 Deficiency and Aspergillus Susceptibility of Card9 Knockout Mice

Cited by 19 publications

References 50 publications

Ten decadal advances in fungal biology leading towards human well-being

Ten decadal advances in fungal biology leading towards human well-being

Case Report: Talaromyces marneffei Infection in a Chinese Child With a Complex Heterozygous CARD9 Mutation

Chronic Pulmonary Aspergillosis: Disease Severity Using Image Analysis and Correlation with Systemic Proinflammation and Predictors of Clinical Outcome

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