Primary Cutaneous Aspergillosis Due to Aspergillus Niger in an Immunocompetent Patient

Abstract

Primary cutaneous aspergillosis is a rare entity, usually caused by A. fumigatus and A. flavus . Here, we present such a case, manifested by ulceration due to A. niger, which remained undiagnosed for a prolonged period. The immunological status was intact, although the patient had associated severe fungal infection. Recurrence of the lesion occurred despite repeated anti-fungal therapies. Anti fungal testing was done based on the broth dilution (M-38A, NCCLS, USA) method. The culture isolate was found to be sensitive to fluconazole and amphotericin B. Continuation of antifungal therapy improved the symptoms, reducing the size of the lesion.

Cutaneous aspergillosis in an immunocompetent patient: a case report

“…It is usually caused by A. flavus, A. fumigatus, and rarely by A. niger. The condition commonly occurs in immunocompromised states such as severe debilitating illness, uncontrolled diabetes, cancer, burns, and chronic granulomatous diseases or HIV, [4,10] but our patient is not having an immunocompromised status. Cutaneous aspergillosis is a rare disease in immunocompetent patients, therefore, poses a diagnostic challenge [6].…”

“…It rarely occurs as a cutaneous infection and is mostly associated with immunodeficiency [2,3]. Aspergillosis is an uncommon opportunistic fungal Manuscript received: 28 th January 2020 Reviewed: 4 th February 2020 Author Corrected: 8 th February 2020 Accepted for Publication: 12 th February 2020 infection that is caused by a number of species of which Aspergillus fumigatus, Aspergillus niger, and Aspergillus flavus are common ones [4]. In immunocompromised patients, primary cutaneous aspergillosis is usually caused by A. flavus and A. fumigatus [4,5].…”

“…Aspergillosis is an uncommon opportunistic fungal Manuscript received: 28 th January 2020 Reviewed: 4 th February 2020 Author Corrected: 8 th February 2020 Accepted for Publication: 12 th February 2020 infection that is caused by a number of species of which Aspergillus fumigatus, Aspergillus niger, and Aspergillus flavus are common ones [4]. In immunocompromised patients, primary cutaneous aspergillosis is usually caused by A. flavus and A. fumigatus [4,5]. A cutaneous aspergillosis is a rare form of a locally invasive lesion that is less commonly associated with Aspergillus niger [4].…”

“…In immunocompromised patients, primary cutaneous aspergillosis is usually caused by A. flavus and A. fumigatus [4,5]. A cutaneous aspergillosis is a rare form of a locally invasive lesion that is less commonly associated with Aspergillus niger [4]. It is seen in, immunocompromised patients or those suffering from tuberculosis, silicosis, malignancies, diabetes or patients on long-term corticosteroids or antibiotics.…”

Aspergillus nigerInfection of an Orbital Exenteration Socket Can Be Treated with Oral Itraconazole

“…Hospital kitchens have also been reported as a source of this fungus [11]. It rarely causes human infection, though skin [12] and soft tissue infection [13], tracheal-oseophageal fistula [14], onychomycosis [15], and mycotic aneurysm [16] have been reported. A foreign body, such as prosthesis, may act as a culture medium for this organism.…”