Primary cutaneous apocrine carcinoma in a 50-year old male

Crabtree, Matthew; Cheng, Doris; Jeon, Caleb; Munteanu, Anamaria; Vadehra, Kumkum; Chiu, R; Venegas, Rose; Smogorzewski, Jan; Shitabata, Paul; Peng, Shi‐Kaung

doi:10.1016/j.hpr.2021.300560

Cited by 3 publications

(5 citation statements)

References 9 publications

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“…Primary cutaneous malignancies of apocrine glands, although rare, have been known to arise de novo or within the background of benign adnexal tumors 1–6 . Our patient reported a 3‐year history of this lesion before presenting for evaluation 7 .…”

Section: Discussionmentioning

confidence: 78%

“…Primary cutaneous malignancies of apocrine glands, although rare, have been known to arise de novo or within the background of benign adnexal tumors. [1][2][3][4][5][6] Our patient reported a 3-year history of this lesion before presenting for evaluation. 7 Had the lesion begun as a malignant tumor, a shorter clinical course from symptom onset to seeking treatment would have been expected.…”

Section: Discussionmentioning

confidence: 89%

“…While a majority of these tumors are indolent and arise de novo, rare cases have been reported arising in a background of benign apocrine neoplasia. [2][3][4][5][6][7] Herein, we report one such case of an apocrine sweat gland carcinoma with morphologic features of apocrine carcinoma arising in a longstanding benign tubular apocrine adenoma of the vulvar region.…”

Section: Introductionmentioning

confidence: 99%

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Primary cutaneous apocrine carcinoma, arising in tubular apocrine adenoma

Griffith,

Singh,

Alabkaa

et al. 2023

J Cutan Pathol

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Primary cutaneous apocrine carcinoma is a rare adnexal tumor that arises from apocrine progenitor cells. These tumors may be associated with benign apocrine hyperplasia, and a longstanding history of a lesion should not preclude a malignant diagnosis. We report a case of a 70‐year‐old female who presented to the clinic with a 3‐year history of an asymptomatic vulvar lesion. An excisional biopsy was performed. Histopathologic examination revealed a tumor with two distinct components. The first component was determined to be a benign tubular apocrine adenoma. The second component, arising within the apocrine adenoma, was determined to be an apocrine carcinoma based on histopathologic features and immunohistochemical profile. Twelve months after subsequent wide local excision and sentinel node biopsy, the patient is alive without recurrence.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Primary cutaneous apocrine carcinoma, arising in tubular apocrine adenoma

Griffith,

Singh,

Alabkaa

et al. 2023

J Cutan Pathol

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“…Therefore, in the case of primary apocrine carcinoma, we found that the cells are positive for cytokeratins CK5/6 and CK7, P63, podoplanin, GCDFP-15 and sometimes are also positive for ostrogenic or progesterone hormone receptors [ 6 , 7 , 9 ]. However, they are negative for mammaglobin and HER2 [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Apocrine Carcinoma of the Thigh: A Rare Case Report

Bouabid,

BenSghier,

Moukhlissi

et al. 2024

Cureus

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Adnexal carcinomas are rare cutaneous malignancies arising from the eccrine and apocrine sweat glands, follicles and sebaceous glands. They occur mainly in elderly people. We report the case of a patient treated for locally advanced apocrine adnexal carcinoma of the thigh, with a review of the literature. The patient was 69 years old, he complained of pruritus on the anterior region of the left thigh four months ago with the appearance of a homolateral inguinal mass without any other associated signs. A left inguinal adenectomy was performed. After almost 15 days, the left inguinal adenopathy reappeared associated with diffuse erythematous nodules on the anterior region of the thigh. The pathological study suggested an adnexal carcinoma of the apocrine type. Surgical treatment was not feasible, therefore primary exclusive radiotherapy was administered at a total dose of 70 Gy in 35 fractions of 2 Gy each. Radiotherapy went well with some adverse events. One-month post-radiation assessment showed clinical and radiological progression.

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“…6 Typically, it presents as a nodule or papule, which may be erythematous or violaceous, and occurs predominantly in the axillary and perineal areas; however, it can also be found in other locations such as the eyelid, scalp, nipple, chest, ear, and fingers. [10][11][12][13] PCAA affects males and females equally, with an over-representation in Caucasians and a peak age between the 6 th and 7 th decades of life. 6,14 At the time of diagnosis, most cases of PCAA are localized in more than half of the cases, while regional or distant metastases occur in about 35% of the cases.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Apocrine Adenocarcinoma of the Axilla in Klinefelter’s Syndrome: A Case Report

Ilerhunmwuwa

Manvar

et al. 2023

Arch Breast Cancer

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Background: Primary Cutaneous Apocrine Adenocarcinoma (PCAA) is a rare cutaneous malignancy that arises from areas rich in apocrine glands, particularly the axilla. There are less than 200 cases described in the literature. However, none has been reported in patients with Klinefelter syndrome, who are known to have an increased risk of breast cancer, Case Presentation: We present a 66-year-old man with a significant family history of breast cancer who developed a right axillary mass initially thought to be hidradenitis suppurativa. On physical examination, he had bilateral gynecomastia. Laboratory workup was significant for hyper-gonadotrophic hypogonadism. Mammography showed bilateral gynecomastia with no radiologic evidence of malignancy in the breast, while magnetic resonance imaging of the breast revealed two suspicious masses seen in the right breast. Excision biopsy of the right axillary mass revealed a high-grade invasive adenocarcinoma involving the dermis and subcutis; the cells had prominent nucleoli vesicular chromatin pattern and voluminous eosinophilic cytoplasm consistent with primary cutaneous apocrine adenocarcinoma. Immunohistochemistry was positive for GATA-3, GCDFP-15, E-cadherin, ER Positive, PR negative, HER 2 by IHC 3 +, and androgen receptor-positive 100 %. Positron emission tomography showed mildly hypermetabolic asymmetric gynecomastia, right greater than left, but no abnormal hypermetabolic activity to suggest malignancy. Karyotype confirmed 47 XXY chromosomes which on. The patient underwent bilateral mastectomy due to his preference; excised breast tissue was negative for malignancy. Conclusion: We presented the first case report of PCAA of axillary in Klinefelter syndrome. Awareness of this association and differentiation from breast carcinoma should be undertaken.

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Primary cutaneous apocrine carcinoma in a 50-year old male

Cited by 3 publications

References 9 publications

Primary cutaneous apocrine carcinoma, arising in tubular apocrine adenoma

Primary cutaneous apocrine carcinoma, arising in tubular apocrine adenoma

Primary Cutaneous Apocrine Carcinoma of the Thigh: A Rare Case Report

Primary Cutaneous Apocrine Adenocarcinoma of the Axilla in Klinefelter’s Syndrome: A Case Report

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