Primary cutaneous anaplastic large‐cell lymphoma: a review of the SEER database from 2005 to 2016

Abstract

Introduction. Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) is a rare T-cell lymphoma. A prior analysis of the Surveillance, Epidemiology, and End Results (SEER) database reported only 157 cases of localized primary cutaneous CD30+ T-cell lymphoproliferative disorders (PC-ALCL and lymphomatoid papulosis) from 1973 to 2004. Our analysis of the SEER database since 2004 is the largest to date and our results improve our understanding of this disease and their potential prognostic factors. Methods. We used the SEER database to retrospectively identify patients. Survival was analysed using the Kaplan-Meier method, and log-rank tests were used to compare survival distributions. Results. There were 501 cases of PC-ALCL recorded from 2005 to 2016. Overall survival rates at 5 and 10 years were found to be 80.6% (95% CI 76.3%-84.3%) and 61.5% (95% CI 54.1%-68.1%) respectively. Age ≥ 60 years [hazard ratio (HR) = 1.09, P = 0.001 and use of chemotherapy (HR = 1.86, P = 0.01)] were associated with lower overall survival. In contrast to the 1973-2004 cohort, the head and neck site was not significantly associated with prognosis on multivariate analysis. Conclusion. PC-ALCL has been increasingly recognized over the past decade. Age > 60 years and use of chemotherapy are associated with a worse outcome. Contrary to prior studies, location was not associated with poor survival.

ALK-Negative Primary Cutaneous Anaplastic Large Cell Lymphoma With Systemic Involvement or Systemic ALCL With Cutaneous Lesion. A Diagnostic Dilemma

“…However, factors such as presence of extracutaneous disease, age above 60 years, or extensive limb involvement are considered to be bad prognostic factors. 14 Visceral metastases may occur within 2 months of initial diagnosis to 10 years. 5,15 Previous reported cases with hepatic involvement in C-ALCL have been complied in Table 1.…”

A Nomogram for Predicting the Risk of Bone Metastasis in Newly Diagnosed Head and Neck Cancer Patients: A Real-World Data Retrospective Cohort Study From SEER Database

“…Age, sex, race, insurance status, and marital status were among the demographic characteristics studied. Age was divided into ≥60 and <60 ( Han et al, 2021 ; Sarfraz et al, 2021 ; Tadros et al, 2021 ; Zhou et al, 2021 ), sex was divided into male and female; race was divided into black, white, and other; single, unmarried or domestic partner, widowed, separated, and divorced were classified as the unmarried group, while the insured/no specifics, insured, and any Medicaid were classified as the insured group. Tumor features included tumor grade (I, II, III, and IV), T stage (T1, T2, T3, and T4), N stage (N0, N1, N2, and N3); the histological type was divided into SCC and other.…”

Diagnosis and prognostic stratification of cutaneous lymphoma

“…61 Similar to MF/SS, some reports found that older age was also associated with unfavorable clinical course. 60,63 Recently, the rearrangement of DUPS22/IRF4 locus on 6p25.3 has been identified in 20-57% cases with PCALCL, [64][65][66] whereas its association with prognosis has not been elucidated yet.…”