Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature

Merika, Eirini; Darling, MI; Craig, Paul; Paul, Milton H.; Francis, N.; Lachmann, HJ; Porter, William M.; Bunker, C.B.

doi:10.1111/bjd.12682

Cited by 20 publications

(23 citation statements)

References 12 publications

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“…2 In our case, however, immunohistochemical findings were positive for 34ßE12, a monoclonal antibody against certain high-molecularweight keratins (cytokeratins 1, 5, 10, 14) that reacts strongly with epidermal keratinocytes 4 and also with the amyloid in macular amyloidosis and lichen amyloidosus. 5 In addition, there was no specific immunostaining for κ or λ light chains.…”

Section: Figure 2 Histopathologic and Immunohistochemical Images Of contrasting

confidence: 48%

“…Our current notion of nodular amyloidosis as immunoglobulin derived is, in fact, based on a small number of individual case reports or case series. 2 The accumulating evidence of a keratinocyte origin for at least some cases of nodular amyloidosis suggests that its causes may be more heterogeneous than previously believed. Management of this condition can be difficult.…”

Section: Figure 2 Histopathologic and Immunohistochemical Images Of mentioning

confidence: 99%

“…Previous reports describe 5 cases of penile nodular amyloidosis that were treated surgically, while 9 required no intervention because they were either asymptomatic or not associated with systemic disease. 2,3 For asymptomatic nodular amyloidosis, conservative management with regular monitoring for systemic progression has been considered reasonable. For more severe cases, surgery may be appropriate.…”

Section: Figure 2 Histopathologic and Immunohistochemical Images Of mentioning

confidence: 99%

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Nodular Amyloidosis of the Penis

et al. 2015

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Lace bug infestations may have health consequences, including nuisance biting and cutaneous and systemic reactions. Clinicians should be aware of the existence of this insect with its newly recognized bloodsucking ability as potentially responsible for skin lesions and pruritus that can cause real discomfort and anxiety. Bites from the lace bug may also be considered in the differential diagnosis of bedbug bites 5 and scabies. 8

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Section: Figure 2 Histopathologic and Immunohistochemical Images Of contrasting

confidence: 48%

Section: Figure 2 Histopathologic and Immunohistochemical Images Of mentioning

confidence: 99%

Section: Figure 2 Histopathologic and Immunohistochemical Images Of mentioning

confidence: 99%

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Nodular Amyloidosis of the Penis

et al. 2015

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“…2 -4,6-8,11,13 There are three additional cases of penile amyloidosis involving not the glans but the shaft 9,13 (one of these is Case 2 in the report by Merika et al). 3 Lesions varied from papules 3 to plaques 1 -5,7,12 and nodules. 3,6,8 In all cases, amyloid was investigated with Congo red, and in some cases, immunohistochemical studies were also used.…”

Section: Discussionmentioning

confidence: 99%

Systemic amyloidosis presenting with glans penis involvement

et al. 2014

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Penile amyloidosis has been reported on many occasions in the literature, but all of these have been forms of primary cutaneous amyloidosis. Systemic amyloidosis presenting with a penile ulcer as the first manifestation has not previously been reported. We present two patients in whom an ulcer of the glans penis was the first complaint that led to a diagnosis of systemic amyloidosis. In both patients, lambda light chain type amyloid was showed immunohistochemically. Both patients presented with other manifestations of systemic amyloidosis, including nail dystrophy characterized by onycholisis, trachyonychia and onychoschizia.

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“…Approximately 12 cases have been reported in the literature, with the common presentation of asymptomatic, nodular, tan/ yellow, and rubbery deposits on the skin of the penis. 69 Of the 3 cases in a report characterized by IHC, 2 were serum amyloid-associated protein, and the other was an AL-k amyloid; the remaining cases were unable to be fully characterized by IHC or mass spectrometry. None were found to be definitively associated with systemic disease.…”

Section: Amyloidosis Of the Genitourinary Tractmentioning

confidence: 99%

Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging

Ellis

Harik

Cohen

et al. 2017

Archives of Pathology &Amp; Laboratory Medicine

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Urologic pathology is evolving rapidly. Emerging trends include the expanded diagnostic utility of biomarkers and molecular testing, as well as adapting to the plethora of technical advances occurring in genitourinary oncology, surgical practice, and imaging. We illustrate those trends by highlighting our approach to the diagnostic workup of a few selected disease entities that pathologists may encounter, including newly recognized subtypes of renal cell carcinoma, pheochromocytoma, and prostate cancer, some of which harbor a distinctive chromosomal translocation, gene loss, or mutation. We illustrate applications of immunohistochemistry for differential diagnosis of needle core renal biopsies, intraductal carcinoma of the prostate, and amyloidosis and cite encouraging results from early studies using targeted gene expression panels to predict recurrence after prostate cancer surgery. At our institution, pathologists are working closely with urologic surgeons and interventional radiologists to explore the use of intraoperative frozen sections for margins and nerve sparing during robotic prostatectomy, to pioneer minimally invasive videoscopic inguinal lymphadenectomy, and to refine image-guided needle core biopsies and cryotherapy of prostate cancer as well as blue-light/fluorescence cystoscopy. This collaborative, multidisciplinary approach enhances clinical management and research, and optimizes the care of patients with urologic disorders. (Arch Pathol Lab Med. 2017;141:499-516; doi: 10.5858.arpa.2016-0263-SA) I n this review, we summarize the effect of a number of biomarker, molecular, and technologic advances in urologic pathology, oncology, and imaging on routine, day-to-day practice and research at our institution. The objective of this review is not to cover the entire gamut of all advances that we have and use at our institution but, rather, to highlight a few pertinent concepts in our field. Topics that will be covered include biomarkers, molecular testing of selected malignancies (eg, transcription factor E3 [TFE3]/ Xp11.2 translocation-associated renal cell carcinoma; p63, high-molecular-weight cytokeratin and racemase cocktail [PIN4]/phosphatase and tensin homolog [PTEN] for some cases of intraductal carcinoma of the prostate; and succinate dehydrogenase subunit B in renal cell carcinoma and pheochromocytoma), amyloidosis of the genitourinary tract, and workup of neoplastic needle core kidney biopsies. In addition, we will report the effect of pathologic, oncologic, and radiologic technologic advances (ie, global transcriptome analysis and RNA biomarkers of prostate cancer; robotic-assisted radical prostatectomy; minimally invasive videoscopic inguinal lymphadenectomy; targeted magnetic resonance imaging [MRI]-guided prostate needle core biopsies; anti-1-amino-3-fluorine 18-fluorocyclobutane-1-carboxylic acid in prostate cancer; cryotherapy for prostate cancer; and blue-light/white-light cystoscopy for bladder lesions) performed at our institution.

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Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature

Abstract: Although primary nodular amyloidosis is a rare entity it seems to be the most frequent presentation of penile-limited cutaneous disease, with a low incidence of systemic involvement.

Cited by 20 publications

References 12 publications

Nodular Amyloidosis of the Penis

Nodular Amyloidosis of the Penis

Systemic amyloidosis presenting with glans penis involvement

Biomarker, Molecular, and Technologic Advances in Urologic Pathology, Oncology, and Imaging

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