Primary cutaneous adenoid cystic carcinoma

Naylor, Elizabeth; Sarkar, P; Perlis, Clifford S.; Giri, Dilip; Gnepp, Douglas R.; Robinson‐Bostom, Leslie

doi:10.1016/j.jaad.2007.12.005

Cited by 80 publications

(112 citation statements)

References 37 publications

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“…The main differential diagnoses that histologically mimic cutaneous ACC are the adenoid-cystic variant of basal cell carcinoma, mucinous carcinoma, dermal cylindroma, and the primary cutaneous cribriform apocrine carcinoma. 6 Tumor site, clinical stage, perineural invasion, and histologic type are the important factors influencing the prognosis of ACC of the salivary glands. From one study involving 91 cases of ACC of salivary glands with a 10-year follow-up, Huang et al 7 concluded that palate and parotid tumors in an early clinical stage with glandular/tubular histologic type without nerve involvement had the best prognosis compared to that of ACC of the submandibular gland, maxillary antrum, and tongue in advanced clinical stage (stage III and IV), and solid histological type with nerve involvement, which had a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot

Agunbiade

Lalehparvar

Khaladj

2017

Journal of the American Podiatric Medical Association

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Adenoid cystic carcinoma is a rare, slow-growing neoplasm. It is most commonly located in the salivary glands, affects people older than 55 years of age, and has a predilection for women. These lesions may recur locally but have shown low metastatic potential. We present the unique case of a 71-year-old female with a nonraised hyperpigmented lesion isolated to the right heel. Confusion surrounded the clinical presentation of this dermatologic lesion, and many physicians postulated several differential diagnoses. The purpose of this case report is to bring further awareness to this rare dermatologic variant of adenoid cystic carcinoma, which has been rarely reported in the literature. (J Am Podiatr Med Assoc 107(5): [457][458][459][460] 2017) Adenoid cystic carcinoma (ACC) is an unusual adnexal skin tumor that may present in any glandular tissue. These lesions are usually located on the salivary glands, scalp, and neck; they rarely occur in the breast, lung, uterine cervix, or prostate. These lesions have unknown etiology; however, recent theories propose that they are derived from apocrine and modified apocrine glands.1 Cutaneous adenoid cystic carcinoma is a rare variant of ACC with unique histopathologic characteristics. Clinically, cutaneous ACC presents as a solitary, ulcerated, slow growing, and normal skin-colored lesion that measures between 0.5 and 10 cm. Histologically, cutaneous ACC tumor cells demonstrate neoplastic changes on the skin and subcutaneous tissue with a collection of basophilic cells in cribriform pattern. Perineural invasion is seen in 76% of cases and not only has prognostic features, but may also increase the risk of local recurrence twofold over lesions without neural changes. 1 Based on the nature of cutaneous ACC and the success rate of Mohs surgery in other cutaneous malignancies that exhibit perineural invasion, Mohs surgery is reported to be superior to wide local excision in achieving a more complete excision of this tumor and reducing the rate of local recurrence of the many primary skin tumors. Case ReportWe present a case of a 71-year-old female who was admitted to our medical center with an altered mental status and an extensive past medical history for type 2 diabetes mellitus, hypertensive cardiovascular disease, dyslipidemia, stroke, dementia, and chronic renal insufficiency. Upon physical examination it was noted and documented by the primary care physician that the patient presented with a painful callus-like lesion on the plantarmedial aspect of the right heel that had been present for approximately 5 to 6 months. The patient denied any recent trauma to the area or active bleeding.Upon further examination of the lesion, it was revealed to be an asymmetrical raised nodule measuring 1.5 3 1.5 cm with irregular thickened borders and a satellite lesion at the 3 o'clock position measuring less than 1 cm (Fig. 1). Because *Podiatric Medicine and Surgery Residency Program,

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Section: Discussionmentioning

confidence: 99%

Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot

Agunbiade

Lalehparvar

Khaladj

2017

Journal of the American Podiatric Medical Association

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“…Kato et al has mentioned that this tumor most commonly arises in the sixth and seventh decades of life and average duration of tumor prior to diagnosis is 9.8 years with a tumor size ranging from 0.5 to 8 cm. 4 The primary modality of management is wide local excision with tumor free margin.…”

Section: Discussionmentioning

confidence: 99%

“…Tumours arising from the outer root sheath of hair follicles comprises of 0.1 % of skin tumors. 4 Pilar tumor is a rare neoplasm arising from the external root sheath of the hair follicle and are observed most commonly on the scalp and clinically present as irregularly defined subcutaneous nodules, which are often cystic and characterized by trichilemmal keratinization.…”

Section: Introductionmentioning

confidence: 99%

Scalp swelling of long duration

Dahal

2017

J Chitwan Med Coll

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Malignant tumors occurring in the scalp are uncommon. When scalp swellings are asymptomatic, small in size or covered by hair usually they are neglected by patients. This may lead to a potential risk of delay in detection and treatment which may cause poorer results. Here we are presenting the case of scalp swelling of unknown duration and pre-operative investigation had showed benign lesion and was managed accordingly but post operatively it was found malignant and metastasized rapidly and become incurable. So any unusual, ulcerated/pigmented lesion of the scalp we must consider the possibility of a tumor and reconstruction with flap should be done after confirmation of the diagnosis.

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“…ACCs may be classified into three different histologic variants-tubular, solid, and cribriform-according to their growth pattern. Among these variants, ACC with a solid growth pattern has a worse prognosis than ACC with a cribriform or tubular growth pattern (4) . Patients with ACC originating from the lacrimal gland have a particularly poor prognosis, even after extended radical excision and radiation.…”

Section: Discussionmentioning

confidence: 99%

“…First described by Boggio et al in 1975, primary cutaneous ACC (PCACC) is a rare type of ACC, with only approximately 60 PCACC cases reported in the literature (4)(5)(6) . Although PCACC has traditionally been considered to originate from the eccrine glands, novel data collected through pathological evaluation indicates that PCACC is of apocrine origin: PCACC may originate from the primary accessory glands of the conjunctiva, ectopic lacrimal gland, and adnexal gland; and it is located in the middle and deep dermis, not continuing into the epidermis (4)(5)(6) . PCACC is most commonly observed in the scalp, which may delay diagnosis, as well as the skin of the chest, and it is usually accompanied by alopecia.…”

Section: Introductionmentioning

confidence: 99%