Primary corneal malignant melanoma in a horse

Strauss, Rachel; Allbaugh, Rachel A.; Haynes, Joseph S.; Ben‐Shlomo, Gil

doi:10.1111/eve.12815

Cited by 8 publications

(8 citation statements)

References 53 publications

(67 reference statements)

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“…Although some masses and adjacent tissues may be heavily pigmented, the tissue may be nonpigmented as in the corneal tumour identified by Strauss et al . (). For this reason, biopsy is indicated for definitive diagnosis in all cases.…”

Section: Clinical Examinationmentioning

confidence: 97%

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Melanocytic ocular and periocular tumours of the horse

Myrna

Sheridan

2017

Equine Veterinary Education

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Section: Clinical Examinationmentioning

confidence: 97%

“…Strauss et al . () present the first published case of a primary corneal melanoma in this issue, reminding us of the need for larger, multi‐institutional studies to characterise these tumours in the horse.…”

Section: Introductionmentioning

confidence: 97%

Melanocytic ocular and periocular tumours of the horse

Myrna

Sheridan

2017

Equine Veterinary Education

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“…A case of primary corneal malignant melanoma has been described in a 13‐year‐old Missouri Fox trotter gelding (Strauss et al., 2019). The horse in this report presented with two irregular, pale pink, superficial corneal masses in association with faint areas of pigmentation throughout the entire cornea.…”

Section: Corneal Neoplasia In Horsesmentioning

confidence: 99%

Corneal neoplasia in horses

Malalana

2022

Equine Veterinary Education

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SummaryPrimary corneal neoplasia in horses is rare. In most cases, tumours extend into the cornea from the adjacent limbus, sclera and/or conjunctiva with only a handful of cases described originating on the cornea. The most common tumour reported affecting the cornea is squamous cell carcinoma with other types of neoplasia described as sporadic case reports. This short clinical commentary accompanies and intends to complement a report of primary corneal lymphoma in a horse (Equine Vet Educ, 2022, https://doi.org/10.1111/eve.13601).

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“…Melanocytic tumours originate from melanocytes and can be benign or malignant, and are most frequently diagnosed in older grey horses (Strauss et al., 2019 ). Equine ocular melanocytic tumours are rare but have been described in adnexal, orbital, epibulbar and intraocular tissues (Strauss et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Extensive intraocular melanoma with secondary glaucoma in a 15‐month‐old Thoroughbred filly

Pereira,

Gillespie,

Rapezzano

et al. 2024

Veterinary Medicine & Sci

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A 15‐month‐old, grey, Thoroughbred filly presented for investigation of a 6‐week history of corneal oedema and blepharospasm on the right eye (OD). The filly was otherwise healthy. Following ophthalmic examination, glaucoma on the OD was diagnosed. A space occupying mass within the anterior chamber was documented on transpalpebral ultrasonographic examination. This mass obliterated most of the anterior intraocular structures on the peripheral nasal side (corneal endothelium and drainage angle), leading to secondary glaucoma. After systemic and topical treatment addressing secondary glaucoma, the corneal oedema reduced. The mass was visualised as an irregularly rounded brown structure associated with the iris on the peripheral nasal side of the anterior chamber. Given the filly's signalment, location and appearance of the mass, a tentative diagnosis of intraocular melanoma was made and enucleation was performed. Histopathological evaluation of the globe revealed solid sheets of heavily pigmented melanocytic cells, disrupting the normal ciliary body architecture and extending into the iris and subretinal. The cells were pleomorphic, polyhedral to round with occasional spindle‐shaped cells, and contained moderate to large amounts of granular black‐brown pigment (melanin). The iridal component expanded into the anterior chamber, with cells directly opposed to Descemet's membrane, with loss of the endothelium and expanding and occluding the filtration angle in this area. The lesion infiltrated locally into the edge of the sclera, but did not extend through the sclera, though occasional perivascular clusters of melanophages were observed within the scleral stroma adjacent to the optic nerve. Diagnosis of a uveal melanocytic neoplasm was confirmed, with characteristics similar to only one reported case . This is a unique case of a rapidly growing, invasive, uveal melanoma in a young horse. Intraocular melanoma should be considered as a differential diagnoses for glaucoma in grey horses, regardless of the age and absence of melanocytic skin lesions.

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Primary corneal malignant melanoma in a horse

Cited by 8 publications

References 53 publications

Melanocytic ocular and periocular tumours of the horse

Melanocytic ocular and periocular tumours of the horse

Corneal neoplasia in horses

Extensive intraocular melanoma with secondary glaucoma in a 15‐month‐old Thoroughbred filly

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