Primary concept of nickel toxicity – an overview

Das, Kusal K.; Reddy, R Chandramouli; Bagoji, Ishwar B.; Das, Swastika; Bagali, Shrilaxmi; Mullur, Lata; Khodnapur, Jyoti P; Biradar, Mallanagouda S.

doi:10.1515/jbcpp-2017-0171

Cited by 236 publications

(111 citation statements)

References 81 publications

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“…Exposure to Ni in daily life can occur through contact with stainless steel kitchen utensils or electronic devices contained nickel alloys, inhaling tobacco or lead-free fuels, and ingesting nickel-containing foods [43,44]. No human enzyme or cofactor contains Ni, and Ni affects health by inducing the production of ROS and activating an immune response to cause allergy.…”

Section: Discussionmentioning

confidence: 99%

Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices

Wen

Wang

et al. 2020

Nutrients

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Previous studies have revealed associations between heavy metals and extensive health problems. However, the association between heavy metals and metabolic problems remains poorly defined. This study aims to investigate relationships between heavy metals and metabolic syndrome (MetS), lipid accumulation product (LAP), visceral adiposity index (VAI), and anthropometric indices, including body roundness index (BRI), conicity index (CI), body adiposity index (BAI), and abdominal volume index (AVI). We conducted a health survey of people living in southern Taiwan. Six heavy metals were measured: lead (Pb) in blood and nickel (Ni), chromium (Cr), manganese (Mn), arsenic (As), and copper (Cu) in urine. A total of 2444 participants (976 men and 1468 women) were enrolled. MetS was defined according to the Adult Treatment Panel III for Asians. Multivariable analysis showed that participants with high urine Ni (log per 1 μg/L; odds ratio (OR): 1.193; 95% confidence interval (CI): 1.019 to 1.397; p = 0.028) and high urine Cu (log per 1 μg/dL; OR: 3.317; 95% CI: 2.254 to 4.883; p < 0.001) concentrations were significantly associated with MetS. There was a significant trend of a stepwise increase in blood Pb and urine Ni, As, and Cu according to the number of MetS components (from 0 to 5, a linear p ≤ 0.002 for trend). For the determinants of indices, urine Cu was positively correlated with LAP, BRI, CI, and VAI; blood Pb was positively correlated with BRI, BAI, and AVI; urine Ni was positively correlated with LAP. High urine Cu and urine Ni levels were significantly associated with MetS, and there was a significant trend for stepwise increases in blood Pb and urine Ni, As, and Cu, accompanied by an increasing number of MetS components. Furthermore, several indices were positively correlated with urine Cu, urine Ni, and blood Pb.

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Section: Discussionmentioning

confidence: 99%

Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices

Wen

Wang

et al. 2020

Nutrients

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“…Chelated Ni 2+ on nitrilotriacetic acid (Ni-NTA) has turned out to be the most effective combination for the purification of His-tagged proteins [11]. However, nickel induced genotoxicity, carcinogenicity and immunotoxicity has been reported [12]. Hence, the development of a carrier with a non-toxic metal ion is highly desirable.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Arabidopsis thaliana Hydroxynitrile Lyase (AtHNL) on EziG Opal

et al. 2020

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Arabidopsis thaliana hydroxynitrile lyase (AtHNL) catalyzes the selective synthesis of (R)-cyanohydrins. This enzyme is unstable under acidic conditions, therefore its immobilization is necessary for the synthesis of enantiopure cyanohydrins. EziG Opal is a controlled porosity glass material for the immobilization of His-tagged enzymes. The immobilization of His6-tagged AtHNL on EziG Opal was optimized for higher enzyme stability and tested for the synthesis of (R)-mandelonitrile in batch and continuous flow systems. AtHNL-EziG Opal achieved 95% of conversion after 30 min of reaction time in batch and it was recycled up to eight times with a final conversion of 80% and excellent enantioselectivity. The EziG Opal carrier catalyzed the racemic background reaction; however, the high enantioselectivity observed in the recycling study demonstrated that this was efficiently suppressed by using citrate/phosphate buffer saturated methyl-tert-butylether (MTBE) pH 5 as reaction medium. The continuous flow system achieved 96% of conversion and excellent enantioselectivity at 0.1 mL min−1. Lower conversion and enantioselectivity were observed at higher flow rates. The specific rate of AtHNL-EziG Opal in flow was 0.26 mol h−1 genzyme−1 at 0.1 mL min−1 and 96% of conversion whereas in batch, the immobilized enzyme displayed a specific rate of 0.51 mol h−1 genzyme−1 after 30 min of reaction time at a similar level of conversion. However, in terms of productivity the continuous flow system proved to be almost four times more productive than the batch approach, displaying a space-time-yield (STY) of 690 molproduct h−1 L−1 genzyme−1 compared to 187 molproduct h−1 L−1 genzyme−1 achieved with the batch system.

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“…Nickel-induced toxicities include genotoxicity, carcinogenicity, and immunotoxicity. [19,20] The general aim of this study is the spatially resolved investigation of metal ion diffusion in PP. Therefore, a time-of-flight secondary ion mass spectrometry (ToF-SIMS) based cryo-approach should be established.…”

Section: Introductionmentioning

confidence: 99%

Spatially resolved indiffusion behavior of Cu²⁺ and Ni²⁺ in polypropylene

Kern

Pradja

et al. 2020

J of Applied Polymer Sci

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Microplastics and their effects on the environment and food chain have become increasingly important in recent years. These polymer particles, which are only few millimeters in size or smaller, accumulate in the environment and can enter the human food chain via animals that ingest them. Moreover, they can accumulate impurities such as heavy metals. Therefore, this study focuses on the indiffusion behavior of metal ions into semicrystalline polypropylene (PP) applying time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) at cryo‐conditions. Diffusion coefficients of Cu2+ and Ni2+ in PP are determined by classical SIMS depth profiling in frozen state (T <−130°C) and subsequent data analysis according to Fick's second law of diffusion. The results show that diffusion of Cu2+ ions in dry PP (DPP,Cu = [2.21 ± 0.15]·10−12 cm2/s) is faster compared to Ni2+ ion diffusion of dry PP (DPP,Ni = [4.43 ± 0.55]·10−13 cm2/s). Interestingly, the diffusion of Cu2+ ions in water‐saturated PP (DPP,H2O,Cu = [1.91 ± 0.28]·10−13 cm2/s) is slower compared to Cu2+ ion diffusion in dry PP. Furthermore, high‐lateral resolution ToF‐SIMS analysis shows that metal ions only diffuse in certain areas of PP, which are most likely amorphous.

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Primary concept of nickel toxicity – an overview

Cited by 236 publications

References 81 publications

Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices

Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices

Immobilization of Arabidopsis thaliana Hydroxynitrile Lyase (AtHNL) on EziG Opal

Spatially resolved indiffusion behavior of Cu²⁺ and Ni²⁺ in polypropylene

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Primary concept of nickel toxicity – an overview

Cited by 236 publications

References 81 publications

Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices

Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices

Immobilization of Arabidopsis thaliana Hydroxynitrile Lyase (AtHNL) on EziG Opal

Spatially resolved indiffusion behavior of Cu2+ and Ni2+ in polypropylene

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Product

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Spatially resolved indiffusion behavior of Cu²⁺ and Ni²⁺ in polypropylene