Primary Colorectal Sarcoma

Meijer, Sybren L.; Peretz, Tamar; Gaynor, Jeffrey J.; Tan, Charlotte; Hajdu, Steven I.; Brennan, Murray F.

doi:10.1001/archsurg.1990.01410210089014

Cited by 52 publications

(3 citation statements)

References 18 publications

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“…Though adjuvant treatment was heterogeneous, our patients were treated with strategies similar to those applied in previous studies. The result, demonstrating that patients who received adjuvant treatment survived no longer than those who did not receive it, is consistent with previous studies [17,18]. However, it is difficult to achieve a wide margin of resection, and patients with the trunk as the primary site need to be evaluated further for identifying the appropriate adjuvant treatment method and indication.…”

Section: Discussionsupporting

confidence: 88%

Vascular Soft-Tissue Sarcomas: A Prognostic Model from a Retrospective Single-Center Study

Park¹,

Kim²,

Cho

et al. 2014

Oncology

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Background: Vascular soft-tissue sarcomas are a rare form of sarcoma. Malignant subtypes exhibit a variety of biological behaviors. We describe the clinicopathological characteristics and patient survival outcomes of malignant vascular soft-tissue sarcomas. Methods: We conducted a retrospective study on a cohort of 84 patients diagnosed with vascular tumors by histological examination at the Yonsei University College of Medicine between April 1987 and August 2011. The primary end point was overall survival (OS). Results: The angiosarcoma patients had a significantly shorter OS than the patients with other subtypes of sarcomas (59.0 and 142.7 months, respectively; p < 0.001). Upon multivariate analysis of survival in patients who underwent surgical resection, the following independent prognostic factors were identified: primary site (trunk, p = 0.001), age (older than 65 years, p < 0.001), pathology (angiosarcoma, p = 0.006) and R2 resection (p = 0.002). Conclusion: The independent prognostic factors for shorter survival are the trunk as the primary site, malignant angiosarcoma and age (>65 years). Complete excision should be attempted for providing a survival advantage in the patients with localized disease. In addition, bleeding episodes are much more frequent in patients with a poor survival outcome.

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Section: Discussionsupporting

confidence: 88%

Vascular Soft-Tissue Sarcomas: A Prognostic Model from a Retrospective Single-Center Study

Park¹,

Kim²,

Cho

et al. 2014

Oncology

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“…Leiomyosarcomas appear to be the most common histological subtype of primary colorectal sarcomas with incidence up to 90%. More rare of their subtypes are liposarcomas, fibrous histiocytomas, and desmoplastic small cell tumors [2]. Regarding the small number of documented cases and their scattered features, prognostic factors and optimal treatment strategy for primary colorectal sarcomas remain indeterminate.…”

Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma of the Rectum as a Radiation-Induced Second Malignancy after Cervical Cancer Treatment: Case Report with Review of the Literature

Makhmudov

Kolesnik

Lagoda

et al. 2019

Case Reports in Oncological Medicine

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Background Incidence of cervical cancer among women of reproductive age still remains significantly high. In regard to prognostic features and risk factors, the standard treatment for most types of cervical cancer represents a combination of surgical treatment and radiation therapy, such as external beam radiation therapy and brachytherapy. Despite significant advances of long-term oncological outcomes, radiation-induced secondary malignancies among cervical cancer survivors are still an issue. Current case report describes an incredibly rare case of radiation-induced leiomyosarcoma of the rectum, which occurred 32 years after cervical cancer treatment. Case Presentation A 62-year-old female had a past medical history of FIGO stage IIB cervical cancer (squamous cell carcinoma pT2bN0M0). In 1987, she underwent radical hysterectomy with bilateral iliac lymph node dissection, followed by adjuvant radiation therapy—70 Gy external beam pelvic irradiation followed by 30.5 Gy of brachytherapy. Thirty-two years later, she presented with signs of rectal bleeding. Regarding past medical history, radiologic, endoscopic, and pathologic data, the patient was initially diagnosed with a malignant nonepithelial lower rectal tumor of the unknown origin and staged as mrT3a mrN0 cM0. Total mesorectal excision with complete mesocolic excision and central vascular ligation (CME/CVL) carried by an open approach was carried out. In an attempt to identify the tissue of origin, an immunohistochemistry assay had been performed. Tumor cells showed a high rate of mitotic activity with a 45% rate of Ki-67 expression, positive reaction for desmin, and SMA in all samples. Negative reaction for CD117 and S100 was observed. As a conclusion, the immunophenotype was identified as a grade 3 leiomyosarcoma (ISD-code 8890/3). Conclusions We suggest that up to date, radical surgery with curative intent, as it was performed in our study, is the most evidence-based treatment option for patients with radiation-induced sarcomas of the rectum.

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“…These tumors typically occur in the fifth and sixth decades of life and show a male predominance [2]. The presenting symptoms are rectal pain, constipation, rectal fullness, and diarrhea, although some patients may be asymptomatic [3]. According to the literature, most rectal leiomyosarcomas are identified as protruding masses during colonoscopic examination and are confirmed histologically [4-6].…”

Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma of the rectum mimicking primary ovarian carcinoma: a case report

Ouh

Min

et al. 2013

J Ovarian Res

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Leiomyosarcoma of the rectum is a very rare mesenchymal tumor. Because of its rarity, its diagnosis, treatment, and pathology often present challenges to the clinician. The characteristics of this tumor, such as its anatomical location, heterogeneous solid features on imaging, and nonspecific lower gastrointestinal tract symptoms, can be confused with those of primary ovarian carcinoma. Here, we report the case of a 52-year-old-woman presenting with a low abdominal mass that was later pathologically confirmed to be a rectal leiomyosarcoma. The findings of preoperative ultrasonography, pelvic magnetic resonance imaging, and abdominopelvic computed tomography were suggestive of a malignant pelvic mass, most likely a primary ovarian carcinoma. The patient underwent explorative laparotomy, and intraoperative frozen examination revealed a sarcoma originating from the gastrointestinal tract. Low anterior resection and supracervical hysterectomy with bilateral salpingo-oophorectomy were performed. The patient’s postoperative course was uneventful, and adjuvant chemotherapy is currently being administered.

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Primary Colorectal Sarcoma

Cited by 52 publications

References 18 publications

Vascular Soft-Tissue Sarcomas: A Prognostic Model from a Retrospective Single-Center Study

Vascular Soft-Tissue Sarcomas: A Prognostic Model from a Retrospective Single-Center Study

Leiomyosarcoma of the Rectum as a Radiation-Induced Second Malignancy after Cervical Cancer Treatment: Case Report with Review of the Literature

Leiomyosarcoma of the rectum mimicking primary ovarian carcinoma: a case report

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