Primary colorectal carcinomas and their intrapulmonary metastases: Clinical, glyco‐, immuno‐ and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival

Kayser, Klaus; Zink, Stefan; André, Sabine; Schüring, Max-Peter; Hecker, Erich; Klar, E.; Bovin, Nicolai V.; Kaltner, Herbert; Gabius, Hans‐Joachim

doi:10.1034/j.1600-0463.2002.100601.x

Cited by 19 publications

(14 citation statements)

References 44 publications

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“…On the other hand, certain lectins are also expressed on the cell surface (Perillo et al, 1998). For instance, galectin-1 and galectin-3 were observed to be upregulated on the surface of colon cancer cells (Lotan et al, 1991;Ohannesian et al, 1994;Schoeppner et al, 1995;Kayser et al, 2001Kayser et al, , 2002Hittelet et al, 2003). This represents a potential use in colon cancer-specific drug delivery (Minko, 2004).…”

Section: B Active Targetingmentioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

2016

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Section: B Active Targetingmentioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

2016

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“…Routine light-microscopic assessment of the sections was performed by the same pathologist. An automated image-analyzing system (DIAS, University of Jena, Germany) was routinely applied for bias-free classification of cases into negative or positive on the basis of staining intensity and number of stained cells as described previously [14, 21]. The results were put into relation with the pT and pN status, the histological findings and survival data.…”

Section: Methodsmentioning

confidence: 99%

“…Sections, 4–6 µm thick, were prepared from the paraffin-embedded tumor tissue and the histochemical staining protocol followed an optimized procedure as reported in detail previously [12, 14]. The biotinylated lectins and hyaluronic acid and the antibodies against lectin were prepared in the Department of Physiological Chemistry at the Faculty of Veterinary Science of the Maximilian Ludwig University.…”

Section: Methodsmentioning

confidence: 99%

Prognostic Significance of Endogenous Adhesion/Growth-Regulatory Lectins in Lung Cancer

et al. 2005

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Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers. Methods: Sections of paraffin-embedded histological material of 481 lungs from lung tumor patients following radical lung excision processed by a routine immunohistochemical method (avidin-biotin labeling, DAB chromogen). Specific antibodies against galectins-1 and -3 and the heparin-binding lectin were tested. Staining by labeled galectins and hyaluronic acid was similarly visualized by a routine protocol. After semiquantitative assessment of staining, the results were compared with the pT and pN stages and the histological type. Survival was calculated by univariate and multivariate methods. Results: Binding of galectin-1 and its expression tended to increase, whereas the parameters for galectin-3 decreased in advanced pT and pN stages at a statistically significant level. The number of positive cases was considerably smaller among the cases with small cell lung cancer than in the group with non-small-cell lung cancer, among which adenocarcinomas figured prominently with the exception of galectin-1 expression. Kaplan-Meier computations revealed that the survival rate of patients with galectin-3-binding or galectin-1-expressing tumors was significantly poorer than that of the negative cases. In the multivariate calculations of survival lymph node metastases (p < 0.0001), histological type (p = 0.003), galectin-3-binding capacity (p = 0.01), galectin-3 expression (p = 0.03) and pT status (p = 0.003) proved to be independent prognostic factors, not correlated with the pN stage. Conclusion: The expression and the capacity to bind the adhesion/growth regulatory galectin-3 is defined as an unfavorable prognostic factor not correlated with the pTN stage.

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“…46 Involvement of thoracic lymph nodes is an independent factor of the postsurgical prognosis. 22,27,29,35 Although lobectomy is the standard technique to remove malignant pulmonary neoplasms, wedge resection has been preferred for surgical treatment of pulmonary metastasis, because hilar and mediastinal lymph node dissection was not as benefi cial for survival in patients with pulmonary metastasis as in patients with primary lung cancer. Pulmonary metastases are often multiple and likely to recur, necessitating repeat pulmonary resection.…”

Section: Extension Of Pulmonary Resectionmentioning

confidence: 99%

“…The 5-year survival after pulmonary metastasectomy from CRC was reported to be 30%-60%. [25][26][27][28][29][30][31][32][33][34][35][36][37][38] …”

Section: Surgical Treatment For Patients With Pulmonary Metastasis Frmentioning

confidence: 99%

Pulmonary metastasis: rationale for local treatments and techniques

Nakajima

2010

Gen Thorac Cardiovasc Surg

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The indication for pulmonary metastasectomy has been postulated based on nonrandomized clinical experiences. The postoperative survival rate of selected patients with pulmonary metastasis is acceptable; nevertheless, pulmonary metastasectomy might cure patients if the neoplastic cells are located only in the lung parenchyma. Computed tomography has been the most reliable preoperative diagnostic methods for identifying pulmonary metastasis. However, it has the limitations that small nodules often cannot be detected, or they are overestimated. Through thoracoscopy, which has largely been applied for metastasectomy in Japan, bimanual palpation during surgery cannot be performed. Considering the fact that the survival rate of the patients undergoing thoracoscopy is not significantly different from that of the patients undergoing conventional thoracotomy, pulmonary metastasectomy is a suboptimal method for eradicating the disease. Less invasive local therapy may be promising for repeat local intervention.

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Primary colorectal carcinomas and their intrapulmonary metastases: Clinical, glyco‐, immuno‐ and lectin histochemical, nuclear and syntactic structure analysis with emphasis on correlation with period of occurrence of metastases and survival

Cited by 19 publications

References 44 publications

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

Prognostic Significance of Endogenous Adhesion/Growth-Regulatory Lectins in Lung Cancer

Pulmonary metastasis: rationale for local treatments and techniques

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