Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis

Bhandari, Kishor; Wang, Diancan; Li, Shanchang; Jiang, Bing‐Hua; Guo, Yuxing; Koirala, Ujjwal; Du, Xiaohui

doi:10.1002/hed.23772

Cited by 28 publications

(21 citation statements)

References 37 publications

(24 reference statements)

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“…2,4,5 We believe that these findings provide evidences that can help to differentiate SDSC from sinonasal undifferentiated carcinoma (SNUC), which according to WHO (2017) classification, it is uncertain if SDSC is a distinct entity, being classified within SNUC spectrum. 23 Recently, a series of 12 SMARCB1 (INI-1)-deficient sinonasal adenocarcinomas of high-grade, with variable degrees of glandular differentiation and foci of intracellular or intraluminal mucin, have been reported, 6 expanding the clinicopathologic spectrum of SMARCB1 (INI-1)-deficient tumors. Loss of this latter leads to upregulation of cyclin D1, resulting in cell-cycle progression.…”

Section: Discussionmentioning

confidence: 99%

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

et al. 2019

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Background: SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively.Methods: Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Moreover, SMARCB1(INI-1)-deficient and NUT carcinomas were additionally evaluated by immunohistochemistry, as well as in situ hybridization analysis for HPV and EBV.Results: Four SMARCB1 (INI-1)-deficient carcinomas (located in lower lip, soft palate, hypopharynx and vocal cord, this latter high-risk HPV positive) and three NUT carcinomas (all located in oropharynx) were detected, previously diagnosed as nonkeratinizing or moderately differentiated squamous cell carcinoma. All cases showed squamous differentiation. NUT carcinomas than SMARCB1 (INI-1)-deficient carcinomas showed low overall survival rate. Conclusion: The current cases expand the clinicopathological spectrum of SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas. Notably, the diagnosis of these cases is easily reached through immunohistochemistry, with impact on their accurate classification, treatment, and prognosis. K E Y W O R D Shead and neck squamous cell carcinoma, immunohistochemistry, in situ hybridization, NUT midline carcinoma, SMARCB1 (INI-1)-deficient carcinoma

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Section: Discussionmentioning

confidence: 99%

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

et al. 2019

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“…[6,[11][12][13] Bununla birlikte bölgesel lenf nodu metastazı gelişen hastalarda yaşam süreleri ciddi oranda düşmektedir. [14][15][16] Dudak kanserlerinde en önemli prognostik faktör boyun metastazı, en önemli ölüm nedeni ise kontrol edilemeyen boyun nüksleridir.…”

Section: Discussionunclassified

The treatment results of patients with lower lip cancer and the relationship of tumor size and depth with neck metastasis

Şengül¹

2017

KBB Uygulamaları

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ÖZAmaç: Bu çalışmada alt dudak kanseri nedeniyle cerrahi tedavi uyguladığımız hastaların tedavi sonuçları ve tümöre ait faktörler ile boyun metastazı ve tümör nüksü arasındaki ilişki incelendi. Hastalar ve Yöntemler:Çalışmaya, Ocak 2009 -Ocak 2016 tarihleri arasında kliniğimizde alt dudak kanseri nedeniyle cerrahi uygulanan 35 hasta (31 erkek, 4 kadın; ort. yaş 58.2 yıl; dağılım 31-81 yıl) dahil edildi. Hastaların demografik özellikleri, muayene ve klinik bulguları, uygulanan cerrahi tedavi yöntemleri, histopatolojik tanı sonuçları geriye dönük olarak değerlendirildi. Tümör boyutu ve derinliği ile boyun metastazı ve tümör nüksü arasındaki ilişki incelenirken sınır değer olarak tümör boyutu 20 mm, derinliği ise 0.6 mm alındı. İstatistiksel analizde p<0.05 değeri anlamlı olarak kabul edildi. Bulgular:Hastaların yedisinde boyun metastazı, beşinde ise cerrahi sonrası nüks tespit edildi. Ek olarak hastaların üçü takip döneminde öldü. Tümör boyutu ≤20 mm olan 20 hastanın birinde boyun metastazı vardı. Bununla birlikte tümör boyutu >20 mm olan 15 hastanın altısında boyun metastazı vardı. Tümör derinliği ≤0.6 mm olan 19 hastanın birinde boyun metastazı tespit edildi. Tümör derinliği >0.6 mm olan 16 hastanın altısında boyun metastazı vardı. Yapılan istatistiksel analizde hem tümör derinliğinin hem de tümör boyutunun boyun metastaz riskini anlamlı oranda artırdığı bulundu (p<0.05).Sonuç: Tümörün boyutunun yanında derinliğinin artışı da boyun metastazı olasılığını artırmaktadır. Bu nedenle tümörün boyutu ve derinliğinin, boyun diseksiyonuna karar vermede belirleyici rol oynayabileceğini düşünmekteyiz.Anahtar sözcükler: Dudak yassı hücreli karsinomu; boyun diseksiyonu; boyun metastazı; cerrahi. ABSTR ACTObjectives: This study aims to evaluate the treatment results and the relationship of tumor size and depth with neck metastasis in patients who were operated for lower lip cancer. Patients and Methods:Thirty-five patients (31 males, 4 females; mean age 58.2 years; range 31 to 81 years), who were operated in our clinic due to lower lip cancer between January 2009 and January 2016, were included in this study. The demographic features, examination and clinical findings, performed surgical treatment techniques and histopathological diagnostic results of the patients were evaluated retrospectively. Twenty millimeter for tumor size and 0.6 mm for depth were taken as the limit values during the evaluation of the relationship of tumor size and depth with neck metastasis. P value below 0.05 (p<0.05) was taken as significant in the statistical analysis. Results:We identified cervical neck metastasis in seven and postoperative recurrences in five patients. In addition, three of them died during the follow-up period. One of the 20 patients with tumor size ≤20 mm had neck metastasis. However, six of the 15 patients with a tumor size >20 mm had neck metastasis. One of the 19 patients with tumor depth ≤0.6 mm had neck metastasis. However, six of the 16 patients with tumor depth >0.6 mm had neck metastasis. In statistical analysis, we foun...

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“…Thus, the gold standard of neck staging is still elective neck dissection (END) and subsequent histopathologic analysis of the surgical specimen . END (of regions I–III) has traditionally been recommended in head and neck SCC when the risk of occult metastases is more than approximately 20% . However, it still carries significant morbidity …”

Section: Discussionmentioning

confidence: 99%

“…Although SCC of the lip is often considered an oral malignancy, it is clearly less aggressive than intraoral SCC proper: metastases to the regional cervical lymph nodes are not as frequent and usually develop later in the course of disease. A 10% cohort subpopulation remains evident, comprising those who will develop regional metastatic disease with a much poorer prognosis: their survival is reduced to approximately 30% to 70% . This is the most important prognostic factor in SCC of the lip, and head and neck SCC in general.…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node biopsy in cN0 squamous cell carcinoma of the lip: A retrospective study

et al. 2015

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Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis

Abstract: The results do not prove sufficient to justify elective treatment of the neck in primary cN0 lip SCC and close observation would be a viable option in such cases. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1392-1400, 2015.

Cited by 28 publications

References 37 publications

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

SMARCB1 (INI‐1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center

The treatment results of patients with lower lip cancer and the relationship of tumor size and depth with neck metastasis

Sentinel lymph node biopsy in cN0 squamous cell carcinoma of the lip: A retrospective study

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