Primary clear cell carcinoma in the liver: CT and MRI findings

Liu, Qingyu; Li, Haigang; Gao, Ming; Lin, Xiaofeng; Li, Yong; Chen, Jianyu

doi:10.3748/wjg.v17.i7.946

Cited by 28 publications

(31 citation statements)

References 25 publications

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“…Because of hypervascular blood supply, typical HCC shows early enhancement at HAP, and rapid washout at PVP or HDP [67,68]. The imaging characteristics of PCCCL are similar to those of HCC [69]. These imaging features may help differentiate PCCCL from other liver tumors.…”

Section: Primary Clear Cell Carcinomamentioning

confidence: 75%

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

Tan

Xiao

2012

Abdom Imaging

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Section: Primary Clear Cell Carcinomamentioning

confidence: 75%

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

Tan

Xiao

2012

Abdom Imaging

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“…Radiographically it can be difficult to distinguish PCCCL from other types of HCC, though there is evidence that PCCCL has a propensity to form pseudo-capsules visible on CT or MRI [10,11]. In our case the mass did not evince such a pseudo-capsule, though most importantly the imaging did not find evidence of malignancy in other organ systems, which helped to establish that the liver was the origin of the cancer.…”

Section: Clinical and Experimental Pathologymentioning

confidence: 59%

A Giant Primary Clear Cell Hepatocellular Carcinoma in a Young Woman without Cirrhosis

Chen¹

2015

J Clin Exp Pathol

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Primary clear cell carcinoma of the liver (PCCCL) is an uncommon variant of hepatocellular carcinoma, usually occurring in older patients with longstanding cirrhosis. We report a case of a giant PCCCL rupturing in a young woman without cirrhosis.A 29 year-old female who presented with a three month history of abdominal pain, nausea, vomiting, food intolerance, and unintentional weight loss, was found to have gastric varices and a large liver mass measuring 22.8 cm × 17.8 cm × 13.8 cm. The tumor was comprised of sheets of clear cells with delicate vesicular architecture, and was positive for Hepar 1, Glypican 3, and CD34 in a diffuse staining pattern and CD10 in a canalicular staining pattern, establishing the diagnosis of PCCCL. The patient died of hemorrhagic shock secondary to tumor rupture within two weeks of diagnosis. Conclusion:Although PCCCL most often occurs in older patients with cirrhosis, this uncommon variant of HCC can arise in younger patients without a history of liver disease. It is important to diagnose PCCCL early due to the potentially favorable prognosis of this specific cancer and in order to prevent catastrophic complications.

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“…There are several studies which show a sensitivity of 92% [20] for double contrast enhanced MRI compared with 50% sensitivity in case of single contrast-enhanced MRI [21] in diagnosing nodules between 1-2 cm. In 2003, it has been demonstrated that angio-MRI increase the diagnostic accuracy of lesions less then 1 cm when comparing with CT (76% versus 61%), and particularly in case of lesions between 1 and 2 cm diameter (84% versus 47%) [22].…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, MRI correctly diagnosed the HCCs misdiagnosed by CEUS and a sensitivity of 91.4%, with a specificity of 98.9% in HCC diagnosis has been found, regardless of nodules size. The various aspects of tumors in MRI depend on tumor architecture, grading, stromal component, as well as intracellular content [20]. The sensitivity of MRI in the detection of HCC is lower in cases with cirrhosis, in advanced stages and in the presence of ascites [23].…”

Section: Discussionmentioning

confidence: 99%

Contrast enhanced ultrasound and magnetic resonance imaging in hepatocellular carcinoma diagnosis

Dumitrescu

Gheonea²,

Săndulescu

et al. 2013

Med Ultrason

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Background: The new developments in imaging technology, including contrast enhanced ultrasound (CEUS), computed tomography (CT), and magnetic resonance imaging (MRI), allow a better diagnosis of both malignant and benign liver lesions. Material and methods: A retrospective trial of 126 patients was conducted in the Gastroenterology and Imaging Departments of the University of Medicine and Pharmacy Craiova, Romania. CEUS and MRI were the imaging techniques used for diagnosis of focal liver lesions (FLL), especially for hepatocellular carcinoma (HCC). Histopathology was used only in 15 cases. For each method of investigation we calculated the sensitivity, specificity, positive and negative predictive values (PPV and NPV), positive and negative likelihood ratio (+LR, -LR), accuracy and we compared the ROC curves. Statistical analysis also included the Chi-square and Kappa tests. Results: Seventy six cases were diagnosed as HCC, with average size of 5.2±3.3 cm in diameter. The sensitivity and specificity were 71.4% and 95.6% for CEUS and 91.4%, 98.9% respectively, for MRI. When comparing the ROC curves, we found a higher area under curve for MRI (0.952) then for CEUS (0.835) (p=0.005), and 95% confidence interval of 0.0343 to 0.199. No statistically significant difference in diagnosis of FLL was found between CEUS and MRI (p > 0.05) and the agreement between the two imaging techniques was good (k = 0.78). Conclusions: CEUS can be used as the first step in the diagnosis of liver lesions, but MRI remains the gold standard diagnostic method for liver tumors.

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Primary clear cell carcinoma in the liver: CT and MRI findings

Abstract: The imaging characteristics of PCCCL are similar to those of CHCC and could be useful for differentiating these from other liver tumors (such as hemangioma and hepatic metastases). PCCCLs are more prone than CHCCs to form pseudo capsules.

Cited by 28 publications

References 25 publications

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

A Giant Primary Clear Cell Hepatocellular Carcinoma in a Young Woman without Cirrhosis

Contrast enhanced ultrasound and magnetic resonance imaging in hepatocellular carcinoma diagnosis

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