Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
Andrea Coschiera,
Masahito Yoshihara,
Gilbert Lauter
et al.
Abstract:Background
Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of ciliary signaling can lead to ciliopathies and certain neurodevelopmental disorders. In the developing brain cilia play well-documented roles for the expansion of the neural progenitor cell pool, while information about the roles of cilia during post-mitotic neuron… Show more
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