Primary cilia are increased in number and demonstrate structural abnormalities in human cancer

Yasar, Binnaz; Linton, Kim; Slater, Christian; Byers, Richard

doi:10.1136/jclinpath-2016-204103

Cited by 34 publications

(29 citation statements)

References 18 publications

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“…The proposed role for ARL13b to act as a tumor suppressor raises the possibility that ARL13b expression in PC could be altered during tumor progression, and in fact, most authors now use two different markers for PC to validate their findings. One study used an antibody for ciliary rootlet coiled-coil (CROCC) for the identification of PC displaying an increase in PC numbers in lung, colon, and pancreatic adenocarcinoma compared to the respective normal tissue and unaltered expression in stomach, prostate, and breast cancer [120]. The findings obtained using CROCC for the identification of PC are somewhat different from the PC expression patterns in the respective tumor tissues described above.…”

Section: General Considerations and Remarksmentioning

confidence: 99%

Mixed signals from the cell's antennae: primary cilia in cancer

Eguether

Hahne

2018

EMBO Reports

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Primary cilia (PC) are antenna‐like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as Hedgehog and WNT. It is therefore not surprising that a dysfunction of PC is frequently associated with pathologies. Originally, PC were found to be involved in a variety of diseases commonly referred to as ciliopathies including cystic kidney diseases. Evidence is accumulating that PC play also an important role in cancer formation and regulation, which is the focus of this review.

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Section: General Considerations and Remarksmentioning

confidence: 99%

Mixed signals from the cell's antennae: primary cilia in cancer

Eguether

Hahne

2018

EMBO Reports

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“…[2,[147][148][149] Medulloblastoma comprises four major subgroups: sonic hedgehog (SHH), WNT, group 3, and group 4. [2,[147][148][149] Medulloblastoma comprises four major subgroups: sonic hedgehog (SHH), WNT, group 3, and group 4.…”

Section: Hedgehog Signaling Regulates Cancer Cell Proliferation Throumentioning

confidence: 99%

Primary Cilia as Signaling Hubs in Health and Disease

et al. 2018

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Primary cilia detect extracellular cues and transduce these signals into cells to regulate proliferation, migration, and differentiation. Here, the function of primary cilia as signaling hubs of growth factors and morphogens is in focus. First, the molecular mechanisms regulating the assembly and disassembly of primary cilia are described. Then, the role of primary cilia in mediating growth factor and morphogen signaling to maintain human health and the potential mechanisms by which defects in these pathways contribute to human diseases, such as ciliopathy, obesity, and cancer are described. Furthermore, a novel signaling pathway by which certain growth factors stimulate cell proliferation through suppression of ciliogenesis is also described, suggesting novel therapeutic targets in cancer.

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“…In contrast with the above examples, cilia have been shown to persist in a range of tumors (Fu et al, 2014;Yasar et al, 2017) and can be found in medulloblastomas exhibiting activation of Hh or Wnt signaling (Han et al, 2009). Strikingly, tumorigenesis is blocked in a medulloblastoma mouse model driven by constitutively active SMO when primary cilia are genetically ablated (Han et al, 2009).…”

Section: Cilia As Tumor Promotersmentioning

confidence: 98%

The regulation of cilium assembly and disassembly in development and disease

2018

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The primary cilium is an antenna-like organelle assembled on most types of quiescent and differentiated mammalian cells. This immotile structure is essential for interpreting extracellular signals that regulate growth, development and homeostasis. As such, ciliary defects produce a spectrum of human diseases, termed ciliopathies, and deregulation of this important organelle also plays key roles during tumor formation and progression. Recent studies have begun to clarify the key mechanisms that regulate ciliary assembly and disassembly in both normal and tumor cells, highlighting new possibilities for therapeutic intervention. Here, we review these exciting new findings, discussing the molecular factors involved in cilium formation and removal, the intrinsic and extrinsic control of cilium assembly and disassembly, and the relevance of these processes to mammalian cell growth and disease.

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Primary cilia are increased in number and demonstrate structural abnormalities in human cancer

Abstract: The results show upregulation of primary cilia and the presence of structural defects in a wide range of human cancer tissue samples demonstrating association of dysregulation of primary cilia with human cancer.

Cited by 34 publications

References 18 publications

Mixed signals from the cell's antennae: primary cilia in cancer

Mixed signals from the cell's antennae: primary cilia in cancer

Primary Cilia as Signaling Hubs in Health and Disease

The regulation of cilium assembly and disassembly in development and disease

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